Main Article Content
Abstract
Cancer is known to be the second most common cause of death, surpassed only by cardiovascular disease. So there has been intense research on various plant resources to develop novel anticancer agents. From the past several years medicinal plants have been proven to be an important natural source for cancer therapy with fewer side effects. There are many natural cytotoxic drugs available, which need further improvement and development of new drugs. The basic aim of this review is to explore the potential of newly discovered anticancer compounds from medicinal plants, as a lead for anticancer drug development. It will be helpful to explore the medicinal value of plants and for new drug discovery from them for the researchers and scientists around the globe.
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Article Details
References
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References
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4. Ancuceanu RV, Istudor V. Pharmacologically active natural compounds for lung cancer. Altern Med Rev. 2004;9(4):402-19. PMID 15656712.
5. Asthana RR, MK. Pharmacology of Withania somnifera- a review. Ind Drugs. 1989;26:1-7.
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7. Belman S. Onion and garlic oils inhibit tumor promotion. Carcinogenesis. 1983;4(8):1063-65. doi: 10.1093/carcin/4.8.1063, PMID 6872151.
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14. Devi PU. Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancerchemotherapy and radiosensitization. Indian J Exp Biol. 1996;34(10):927-32. PMID 9055640.
15. Devi PU, Akagi K, Ostapenko V, Tanaka Y, Sugahara T. Withaferin A: a new radiosensitizer fromthe Indian medicinal plant Withania somnifera. Int J Radiat Biol. 1996;69(2):193-97. doi: 10.1080/095530096146020, PMID 8609455.
16. Diogo CV, Félix L, Vilela S, Burgeiro A, Barbosa IA, Carvalho MJM et al. Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin – relevance for possible anti-cancer application. Toxicol In Vitro. 2009;23(5):772-9. doi: 10.1016/j.tiv.2009.04.002, PMID 19362137.
17. Dixon RA, Ferreira D. Genistein. Phytochemistry. 2002;60(3):205-11. doi: 10.1016/s0031-9422(02)00116-4, PMID 12031439.
18. Dubey KK, Ray AR, Behera BK. Production of demethylated colchicine through microbial transformation and scale-up process development. Process Biochem. 2008;43(3):251-7. doi: 10.1016/j.procbio.2007.12.002.
19. Efferth T, Li PCH, Konkimalla VSB, Kaina B. From traditional Chinese medicine to rational cancer therapy. Trends Mol Med. 2007;13(8):353-61. doi: 10.1016/j.molmed.2007.07.001, PMID 17644431.
20. Fuchs C, Mitchell EP, Hoff PM. Irinotecan in the treatment of colorectal cancer. Cancer Treat Rev. 2006;32(7):491-503. doi: 10.1016/j.ctrv.2006.07.001, PMID 16959432.
21. Fulda S. Betulinic acid for cancer treatment and prevention. Int J Mol Sci. 2008;9(6):1096-107. doi: 10.3390/ijms9061096, PMID 19325847.
22. Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as ”Curecumin”: from kitchen to clinic. Biochem Pharmacol. 2008;75(4):787-809. doi: 10.1016/j.bcp.2007.08.016, PMID 17900536.
23. Hait WN, Rubin E, Alli E, Goodin S. Tubulin targeting agents. Updateon Cancer Ther. 2007;2(1):1-18. doi: 10.1016/j.uct.2006.10.001.
24. Hampson P, Wang K, Lord JM. Treatment of actinic keratoses, acute myeloid leukemia therapy, Treatment of basal cell carcinoma, protein kinase C activator. Drugs Fut. 2005;30:1003.
25. Hazra B, Sarma MD, Sanyal U. Separation methods of quinonoid constituents of plants used in oriental traditional medicines. J Chromatogr B. 2004;8(12):259-75.
26. Herst PM, Davis JE, Neeson P, Berridge MV, Ritchie DS. The anticancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells. Haematologica. 2009;94(7):928-34. doi: 10.3324/haematol.2008.003996, PMID 19535345.
27. Huma A, Savita D. Extraction optimization of Tinospora cordifolia and assessment of the anticancer activity of its alkaloid palmatine. Sci World J. 2013:1-10.
28. Huang Z, Chen G, Shi P. Effects of emodin on the gene expression profilingof human breast carcinoma cells. Cancer Detect Prev. 2009;32(4):286-91. doi: 10.1016/j.cdp.2008.12.003, PMID 19185431.
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30. Bruneton J.Pharmacognosy, phytochemisty medicinal plants. France: Lavoisier Publisher;1993.p.771-77.
31. Bruneton J. Pharmacognosy, phytochemisty medicinal plants. France: Lavoisier Publisher; 1993. p. 151.
32. Bruneton J. Pharmacognosy, phytochemisty medicinal plants. France: Lavoisier Publisher; 1993. p. 281.
33. Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhizakurroa on N-nitrosodiethylamine induced hepatocardinogenesis. Cancer Lett. 1999;136(1):11-6. doi: 10.1016/s0304-3835(98)00294-8, PMID 10211933.
34. Jeong SY, Park SJ, Yoon SM, Jung J, Na Woo HN, Yi SL et al. Systemic delivery and preclinical evaluation of Au nanoparticle containing β-lapachone for radiosensitization. J Control Release. 2009;139(3):239-45. doi: 10.1016/j.jconrel.2009.07.007, PMID 19619590.
35. Khan T, Ali M, Khan A, Nisar P, Jan SA, Afridi S et al. Anticancer plants: a review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules. 2019 Dec 27;10(1):47;10(1). doi: 10.3390/biom10010047, PMID 31892257.
36. Kim S, Hwang BY, Su BN, Chai H, Mi Q, Kinghorn AD et al. Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7. Anticancer Res. 2007;27:2175-83.
37. Kinghorn AD, Carcache de Blanco EJC, Chai HB, Orjala J, Farnsworth NR, Soejarto DD et al. Discovery of anticancer agents of diverse natural origin. Pure Appl Chem. 2009;81(6):1051-63. doi: 10.1351/PAC-CON-08-10-16, PMID 20046887.
38. Kingston DGI. The shape of things to come: structural and synthetic studiesof Taxol and related compounds. Phytochemistry. 2007;68(14):1844-54. doi: 10.1016/j.phytochem.2006.11.009, PMID 17184797.
39. Kikuzaki H, Nakatani N. Antioxidant effects of some ginger constituents. J Food Sci. 1993;58(6):1407-10. doi: 10.1111/j.1365-2621.1993.tb06194.x.
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