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Abstract
Ethanolic extract of whole plant of Alternanthera Philoxeroides (Family: Amaranthaceae) was assessed for its anti-inflammatory activity by in vitro methods. In vitro anti-inflammatory activity was evaluated using albumin denaturation assay activity at different concentrations. Diclofenac sodium was used as standard drugs. The results showed that ethanolic extraction of Alternanthera Philoxeroides (EEAP) at a concentration range of 100-1000µg/ml significantly (p<0.01) protects the heat induced protein denaturation. EEAP showed significant (p<0.01). The results obtained in the present study indicate that ethanolic extracts of Alternanthera Philoxeroides can be a potential source of anti-inflammatory agents.
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References
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- 2. Kirtikar k r & basu b d. Indian medicinal plants. 2nd ed, (bishen sing mahendre pal sing, dehradun, india); 1999. p. 1655.
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- 13. Luo H, Cai Y, Peng Z, Liu T, Yang Shengjie. T: chemical composition and in-vitro evaluation of the cytotoxic and antioxidant activities of supercritical carbon dioxide extracts of pitaya (dragon fruit) peel. Chem Cent J. 2014;8(1):1. doi: 10.1186/1752-153X-8-1, PMID 24386928.
- 14. Donaji Ortiz-Hernandez Y, Carrillo-Salazar JA. T: pitahaya (Hylocereus sp): a short review. Comun Sci. 2012;3(4):220-37.
- 15. Sheikh MV. Navin Devadiga and Manish Hate, An in-vitro anti-inflammatory and antioxidant activity of Anisomeles malabarica R. Br. ex Sims. J Chem Pharm Res. 2016;4(8), Pg. No: 1062-1067.
- 16. Leelaprakash G, Dass SM. In-vitro anti-inflammatory activity of methanolic extract of Enicostemma axillare. Int J Drug Dev Res. 2011;3(3).
- 17. Govindappa M, Naga Sravya S, Poojashri M. N, Sadananda T. S and Chandrappa C. P, antimicrobial, antioxidant and in-vitro anti-inflammatory activity of ethanolic extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. J Pharmacogn Phytother. 2011;3(3). Pg. No. 43-51.
- 18. Nasreen Begum, Srisailam K, and Uma Maheshwara Rao V, Investigation of in-vitro anti-inflammatory and COX-2 inhibitory activity of root extracts of Berberis aristata. Int J Pharm Biol Sci. 2016;6(2).
References
1. Tortora GJ, Reynolds S, editors. Principles of anatomy and physiology. Harper Collins college publishers. 7th ed; 1993. p. 695.
2. Kirtikar k r & basu b d. Indian medicinal plants. 2nd ed, (bishen sing mahendre pal sing, dehradun, india); 1999. p. 1655.
3. Sadique J, Chandra T, Thenmozhi V, Elango V. The anti-inflammatory activity Enicostemma littorale and mullogo cerviana. Biochem Med Metab Biol. 1987;37(2):167-76. doi: 10.1016/0885-4505(87)90023-5, PMID 2885019.
4. Jyoti M, Vasu VT, Ravikumar A, Sarita G. Glucose lowering effect of aqueous extract if Enicostemma littorale Blume in diabetes a possible mechanism of action. J Ethnopharmacol. 2000;81:199-204.
5. Murali B, Upadhyaya UM, Goyal RK. Effect of chronic treatment with Enicostema littorale Blume in non-insulin dependent diabetic rats. J Ethnopharmacol. 2002;81(2):199-204. doi: 10.1016/S0378-8741(02)00077-6.
6. Jyoti M. Vasu V T and guptam S. Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale blum in allaxon- induced diabetic rats. Phytomedicine. 2003;10:196199.
7. Kirtikar KR, Basu BD. Indian medicinal plants. 2nd ed, Bishen Sing. Dehradun: Mahendra Pal Sing publication; 1999. p. 16551656.
8. Varier ps. Indian medicinal plants vol. 2. Chennai: orient longman (pvt) ltd; 1994. p. 374.
9. Garg sc, ethnomedicine for snake bite. J Arom Plant Sci. 2000-2001;22(4a) & 23(1a):546-53.
10. Dr. Khandelwal KR. Practical Pharmacognosy – Techniques and Experiments, Preliminary Phytochemical Screening, Pg. No. 149-156.
11. Mizushima Y, Kobayashi M. Interaction of anti‐inflammatory drugs with serum preoteins, especially with some biologically active proteins. J Pharm Pharmacol. 1968;20(3):169-73. doi: 10.1111/j.2042-7158.1968.tb09718.x, PMID 4385045.
12. Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharm Sci. 2010;2(1):146-55.
13. Luo H, Cai Y, Peng Z, Liu T, Yang Shengjie. T: chemical composition and in-vitro evaluation of the cytotoxic and antioxidant activities of supercritical carbon dioxide extracts of pitaya (dragon fruit) peel. Chem Cent J. 2014;8(1):1. doi: 10.1186/1752-153X-8-1, PMID 24386928.
14. Donaji Ortiz-Hernandez Y, Carrillo-Salazar JA. T: pitahaya (Hylocereus sp): a short review. Comun Sci. 2012;3(4):220-37.
15. Sheikh MV. Navin Devadiga and Manish Hate, An in-vitro anti-inflammatory and antioxidant activity of Anisomeles malabarica R. Br. ex Sims. J Chem Pharm Res. 2016;4(8), Pg. No: 1062-1067.
16. Leelaprakash G, Dass SM. In-vitro anti-inflammatory activity of methanolic extract of Enicostemma axillare. Int J Drug Dev Res. 2011;3(3).
17. Govindappa M, Naga Sravya S, Poojashri M. N, Sadananda T. S and Chandrappa C. P, antimicrobial, antioxidant and in-vitro anti-inflammatory activity of ethanolic extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. J Pharmacogn Phytother. 2011;3(3). Pg. No. 43-51.
18. Nasreen Begum, Srisailam K, and Uma Maheshwara Rao V, Investigation of in-vitro anti-inflammatory and COX-2 inhibitory activity of root extracts of Berberis aristata. Int J Pharm Biol Sci. 2016;6(2).