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Abstract
Acute pancreatitis (AP) is characterised by inflammation of the exocrine pancreas and is associated with acinar cell injury and both a local and systemic inflammatory response. AP may range in severity from self-limiting, characterised by mild pancreatic oedema, to severe systemic inflammation with pancreatic necrosis, organ failure and death. Most patients with acute pancreatitis have mild form of the disease about 20-30%develops a severe form ,often associated with single or multiple organ dysfunction requiring intensive care .the study is based upon the etiology ,epidemiology ,pathophysiology and advanced treatment of pancreatitis
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References
- 1. Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA. Increasing United States hospital admissions for acute pancreatitis, 1988-2003. Ann Epidemiol. 2007 Jul;17(7):491-7.
- 2. .Werge M, Novovic S, Schmidt PN, Gluud LL. Infection increases mortality in necrotizing pancreatitis:
- 3. A systematic review and meta-analysis. Pancreatology. 2016 Sep-Oct;16(5):698-707.
- 4. 3.Valverde-López F, Wilcox CM, Redondo-Cerezo E. Evaluation and management of acute pancreatitis in Spain. Gastroenterol Hepatol. 2018 Dec;41(10):618-628.
- 5. Kahaleh M. Management of pancreatitis and pancreatic: fluid collections. Rev Gastroenterol Peru. 2018 Apr-Jun;38(2):169-182.
- 6. 5.Bazerbachi F, Haffar S, Hussain MT, Vargas EJ, Watt KD, Murad MH, Chari S, Abu Dayyeh BK. Systematic review of acute pancreatitis associated with interferon-α or pegylated interferon-α: Possible or definitive causation? Pancreatology. 2018 Oct;18(7):691-699.
- 7. 6.Ortiz Morales CM, Girela Baena EL, Olalla Muñoz JR, Parlorio de Andrés E, López Corbalán JA. Radiology of acute pancreatitis today: the Atlanta classification and the current role of imaging in its diagnosis and treatment. Radiologia (Engl Ed). 2019 Nov-Dec;61(6):453-466.
- 8. 7.Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981.
- 9. 8.Bazerbachi F, Haffar S, Hussain MT, Vargas EJ, Watt KD, Murad MH, Chari S, Abu Dayyeh BK. Systematic review of acute pancreatitis associated with interferon-α or pegylated interferon-α: Possible or definitive causation? Pancreatology. 2018 Oct;18(7):691-699.
- 10. 9.Fonseca Sepúlveda EV, Guerrero-Lozano R. Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. J Pediatr (Rio J). 2019 Nov-Dec;95(6):713-719.
- 11. Barbara M, Tsen A, Rosenkranz L. Acute Pancreatitis in Chronic Dialysis Patients. Pancreas. 2018 Sep;47(8):946-951.
- 12. 11.Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981.
- 13. Lankisch PG, Breuer N, Bruns A, Weber-Dany B, Lowenfels AB, Maisonneuve P. Natural history of acute pancreatitis: a long-term population-based study. Am J Gastroenterol. 2009 Nov;104(11):2797-805; quiz 2806.
- 14. .https://www.mayoclinic.org/diseases-conditions/pancreatitis/symptoms-causes/syc-20360227
- 15. .Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun;144(6):1252-61 https://emedicine.medscape.com/article/181364-overview?form=fpf
- 16. Dipiro pharmacotherapy text book
References
1. Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA. Increasing United States hospital admissions for acute pancreatitis, 1988-2003. Ann Epidemiol. 2007 Jul;17(7):491-7.
2. .Werge M, Novovic S, Schmidt PN, Gluud LL. Infection increases mortality in necrotizing pancreatitis:
3. A systematic review and meta-analysis. Pancreatology. 2016 Sep-Oct;16(5):698-707.
4. 3.Valverde-López F, Wilcox CM, Redondo-Cerezo E. Evaluation and management of acute pancreatitis in Spain. Gastroenterol Hepatol. 2018 Dec;41(10):618-628.
5. Kahaleh M. Management of pancreatitis and pancreatic: fluid collections. Rev Gastroenterol Peru. 2018 Apr-Jun;38(2):169-182.
6. 5.Bazerbachi F, Haffar S, Hussain MT, Vargas EJ, Watt KD, Murad MH, Chari S, Abu Dayyeh BK. Systematic review of acute pancreatitis associated with interferon-α or pegylated interferon-α: Possible or definitive causation? Pancreatology. 2018 Oct;18(7):691-699.
7. 6.Ortiz Morales CM, Girela Baena EL, Olalla Muñoz JR, Parlorio de Andrés E, López Corbalán JA. Radiology of acute pancreatitis today: the Atlanta classification and the current role of imaging in its diagnosis and treatment. Radiologia (Engl Ed). 2019 Nov-Dec;61(6):453-466.
8. 7.Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981.
9. 8.Bazerbachi F, Haffar S, Hussain MT, Vargas EJ, Watt KD, Murad MH, Chari S, Abu Dayyeh BK. Systematic review of acute pancreatitis associated with interferon-α or pegylated interferon-α: Possible or definitive causation? Pancreatology. 2018 Oct;18(7):691-699.
10. 9.Fonseca Sepúlveda EV, Guerrero-Lozano R. Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. J Pediatr (Rio J). 2019 Nov-Dec;95(6):713-719.
11. Barbara M, Tsen A, Rosenkranz L. Acute Pancreatitis in Chronic Dialysis Patients. Pancreas. 2018 Sep;47(8):946-951.
12. 11.Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med. 2016 Nov 17;375(20):1972-1981.
13. Lankisch PG, Breuer N, Bruns A, Weber-Dany B, Lowenfels AB, Maisonneuve P. Natural history of acute pancreatitis: a long-term population-based study. Am J Gastroenterol. 2009 Nov;104(11):2797-805; quiz 2806.
14. .https://www.mayoclinic.org/diseases-conditions/pancreatitis/symptoms-causes/syc-20360227
15. .Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun;144(6):1252-61 https://emedicine.medscape.com/article/181364-overview?form=fpf
16. Dipiro pharmacotherapy text book