Main Article Content
Abstract
Background: Ougeinia oojeinensis is a plant known for its medicinal properties. In this study, we aimed to investigate the phytochemical composition and pharmacological activities of the bark extracts of Ougeinia oojeinensis.
Methods: The bark of Ougeinia oojeinensis was extracted using the soxhlation method with three different solvents: methanol, ethyl acetate, and petroleum ether. The percentage yield of each extract was determined. Phytochemical screening was performed to identify the presence of various bioactive compounds, including Carbohydrates, Flavonoids, Tannins, Phenolics, and Fats. The extracts were further evaluated for their Anti-Inflammatory and Antioxidant activities using appropriate in vitro assays.
Results: Among the three solvents, the methanol extract exhibited the highest percentage yield, indicating its efficient extraction of bioactive compounds from the bark. Phytochemical screening revealed the presence of carbohydrates, flavonoids, tannins, phenolics, and fats in the methanolic and ethyl acetate extracts. The petroleum ether extract contained fats as the sole detected compound. In terms of pharmacological activities, the methanolic extract showed the most significant Anti-Inflammatory and Antioxidant activities, suggesting its potential therapeutic application.
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References
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References
1. Shete S. S, Jadhav R, Vikhe S. A Review on Pharmacognostical and Pharmacological Activity of Ougeinia oojeinensis.Asian J Res PharmSci. 2022Mar5:17-20.Doi: 10.52711/2231-5659.2022.00004
2. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget.2018Jan23;9(6):7204-18. doi: 10.18632/oncotarget.23208, PMID 29467962.
3. Sarveshwaran R, Jayasuriya WJABN, Suresh TS. In-vitro assays to investigate the anti-inflammatory activity of herbal extracts: a review. World J Pharm Res.2017Oct29;6(17):131-41.doi:10.20959/wjpr201717-10058
4. Sahu R, Roy A. Hepatoprotective activity of ethanolic extract of Ougeinia oojeinensisbarks in ccl4 treated male rats;2009;2:1-5. Available from: https://pharmacologyonline.silae.it/files/archives/2009/vol2/001.Kumar.pdf
5. Jagtap S, Deokule S, Pawar P, Kuvalekar A, Harsulkar A. Antimicrobial activity of some crude herbal drugs used for skin diseases by Pawra tribes of Nandurbar district. Indian J Nat Prod Resour.2010;1(2):216-220. Available from: https://nopr.niscpr.res.in/bitstream/123456789/9829/1/IJNPR%201(2)%20216-220.pdf
6. Sahu RK. Healing potential of gel containing extract of Ougeinia oojeinensison excision wounds in Wistar rats.Article in Journal of Global.PharmTechnol. 2009.[cited 2023 Mar 28]; Available from: www.jgpt.co.in.
7. Singh J, Sahu RK, Andan Prasad D, Jangde R, Gupta R. Evaluation of antidiabetic potential of Ougeinia oojeinensisleaves in streptozotocin-induced-diabetic rats. pharmacology online;2011. p. 1046-52. Available from: https://pharmacologyonline.silae.it/files/archives/2011/vol2/107.singh.pdf