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  Diabetes mellitus is a major metabolic disorder whose prevalence is increasing daily. Medicinal plants have played an important role in the prevention and treatment of Diabetes mellitus.In ethnomedicinal practices, different parts of Mangifera indica are used for the treatment of diabetes. Mangifera indica extract showed presence of secondary metabolites such as tannins, xanthones, flavonoids, and terpenoids etc. These secondary metabolites are responsible for the anti-diabetic activity. In this study Mangifera indica chloroform peel extract was investigated for its promising anti-diabetic activity via an in vivo model. This experiment was conducted in a set of five with five groups of animals namely control group, toxicant group, standard group, Test I group and Test II group. To develop diabetes, Wistar rats were injected alloxan monohydrate intraperitoneally. Test I and Test II groups received a freshly prepared single dose of Mango peel chloroform extract in rice bran oil. All experimental groups received laboratory pallet feed diet and drinking water. Diabetic rats were treated for 21 days with an chloroform extract of mango peel orally daily at rates of 150 mg/kg b.w. and 200 mg/kg b.w. followed by histopathological evaluation of pancreas. It was found that Mangifera indica chloroform peel extract possessed highly significant activity (p > 0.001) at a concentrations of 150 mg/kg and 200 mg/ decreased the fasting blood levels in alloxan induced diabetic rats where as, standard metformin (200 mg/kg b.w.) showed significant (p<0.001) decrease in the fasting blood glucose levels.


Mangifera Indica Anti-Diabetic Chloroform extract Metformin Alloxan monohydrate

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Zeeyauddin K, Sanjana G, Nagesh B, Vikas G, Mounika K, & Tulja Rani G. (2023). Invivo Evaluation Of Anti-Diabetic Activity Of Chloroform Peel Extract Of Mangifera Indica. International Journal of Research in Pharmacology & Pharmacotherapeutics, 12(4), 267-276. Retrieved from


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