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The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Telmisartan used for is a medication used for high blood pressure, heart failure, and diabetic kidney disease. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Telmisartan in the inner core were formulated by direct compression method with an outer coating of different amount of Chitosan.  The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave good drug release of 99.58 %


Telmisartan Sodium Alginate HPMC K100M and Chitosan and press coated method

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How to Cite
Saka Abisheknath, A. Venkateswara Rao, & M. Vineela. (2023). Preparation and evaluation of press coated floating pulsatile drug delivery system of telmisartan. International Journal of Research in Pharmacology & Pharmacotherapeutics, 12(3), 166-174.


  1. 1. J.ravi kumar reedy,m.veera jyothsna,t.s.mohamed saleem,c.madhu sudhana chetty. Pulsatile drug delivery systems. J Pharm Sci Res. 2009;1(4):109-11.
  2. 2. Ramesh d, parmar rk, parikh g. vidyasagar,dhaval. Pulsatile drug delivery systems. Int J Pharm Sci Nanotechnol. 2009;3:605-11.
  3. 3. Nobuhiko Y, Teruo O, Yasuhisa S. Yui n, okano t and Sakurai y. In flammation responsive degradation of cross linked hyaluronic acid gels. J Control Release. 1992;22(2):105-16. doi: 10.1016/0168-3659(92)90195-W.
  4. 4. Chaudhari Hs, Lohar ms, Amritkar as, Jain dk, dheeraj t. baviskar. Pulsatile drug delivery system. Int J Pharm Sci Rev Res. 2011;8(2):160-9.
  5. 5. El-Maradny HA. Modulation of a pulsatile release drug delivery system using different swellable / rupturable materials. Drug Deliv. 2007;14(8):539-46. doi: 10.1080/10717540701606574, PMID 18027184.
  6. 6. Keerthi S, reddy vb. gopal muralidharan1, l. v.g nargund1. Formulation and evaluation of pulsatile drug delivery system of anti-asthmatic drug. Am. J. Pharmtech res. 2014;4(1):797-809.
  7. 7. Dubey J, Verma N. Floating drug delivery system: a review. IJPSR. 2013;4(8):2893-9.
  8. 8. Chikhalikar SS, Wakade RB. Floating drug delivery system – an approach to oral controlled drug delivery. Int J PharmTech Res. 2012;4(4):1812-26.
  9. 9. Tripathi GK, Singh S. Formulation and in vitro evaluation of pH sensitive oil entrapped polymeric blended buoyant beads of amoxicillin. Scholars research library. 2010;2(2):131-38.
  10. 10. Burns SJ, Attwood D, Barnwell SG. Assessment of a dissolution vessel designed for use with floating and erodible dosage forms. Int J Pharm. 1998;160(2):213-18. doi: 10.1016/S0378-5173(97)00312-8.
  11. 11. Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimisation of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000;195(1-2):125-35. doi: 10.1016/s0378-5173(99)00378-6, PMID 10675690.
  12. 12. Kharia AA, Hiremath SN, Singhai AK, Omray LK, Jain SK. Design and optimization of floating drug delivery system of acyclovir. Indian J Pharm Sci. 2010;72(5):599-606. doi: 10.4103/0250-474X.78527, PMID 21694992.
  13. 13. Bhowmik D, Chiranjib B, Margret C, Jayakar B, Kumar KPS. Floating drug delivery system-A review. Scholars research library. 2009;1(2):199-18.
  14. 14. narang N. An updated review on: Floating Drug Delivery System (Fdds).
  15. 15. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: a review. AAPS PharmSciTech. 2005;6(3):E372-90. doi: 10.1208/pt060347, PMID 16353995.
  16. 16. Chien YW. Rate‐control drug delivery systems: controlled release vs. sustained release. Med Prog Technol. 1989;15(1-2):21-46. PMID 2530424.
  17. 17. Chien YW. Oral drug delivery and delivery system in novel drug delivery systems, ed. Vol. 50. NY: Marcel Dekker publication; 1992.
  18. 18. Patel GM. Floating Drug Delivery System: an Innovative Approach to Prolong Gastric Retention; 2007. Available from:
  19. 19. Koner P, Saudagar RB, Dharwal J. Gastro‐retentive drugs a novel approach towards floating therapy in‐retentive drugs a novel approach towards floating therapy/, 2007.
  20. 20. Mathur P, Verma N. Floating drug delivery system: an innovative acceptable approach in gastroretentive drug delivery. Scholars research library. 2010;2(2):257-70.
  21. 21. Chandel A, Chauhan K, Parashar B, Kumar H, Arora S. Floating drug delivery systems: A better approach. Int Curr Pharm J. 2012;1(5):110-18.
  22. 22. Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: a review. International journal of pharmaceutical. Technology Publishing and Research 2009; 1(3): 623-33.
  23. 23. Gopalakrishnan S, Chenthilnathan A. Floating drug delivery system: a review. J Pharm Sci Technol. 2011;3(2):548-54.
  24. 24. Vedha H, Chaudhary J. The recent developments on gastric floating drug delivery system: an overview. Journal of pharmaceutical. Technology Publishing and Research 2010; 2(1); 524-34.