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BACKGROUND: Rheumatoid arthritis [RA] is a chronic inflammatory disease characterized by progressive joint erosion, resulting in significant disability, morbidity and increased mortality. The introduction of DMARDs in the treatment of rheumatic diseases over the last two decades has significantly improved clinical outcomes. Disease modifying anti-rheumatic drugs [DMARDs] is a group of drugs that slow or stop the immune system from destroying the joints. These agents can retard or prevent disease progression and thus joint destruction and subsequent loss of function. All DMARDs show significant toxicity, such that their use requires regular monitoring.
OBJECTIVES: To identify and evaluate the drug related Side effects with the use of DMARD’s in RA patients. To establish role of pharmacist to minimize side effects with DMARDs.

METHODS: A prospective study was conducted on the use of DMARDs and their Side effects. Data was collected between January 2021 – July 2021 from orthopedic and rheumatology clinics within the hospital from out-patient department. The data collected was entered in a data collection form designed for the purpose and included all the required parameters. The obtained information was used to understand the side effects of DMARDs.

RESULTS: In our study 65% of the patients reported side effects and other 35% of the patients didn’t have any side effects. In females, age group of 51-60 were mostly affected with RA than other age groups where as in males age group of 41-50 were mostly affected. Other side effects reported in patients taking DMARDs include Vomiting, Acidity, Fever, Dizziness, Dyspepsia, Swelling of tongue, Pigmentation of skin, Insomnia, Blurred vision and increased Appetite.

CONCLUSION: The side effects associated with disease modifying anti rheumatoid drugs in rheumatoid arthritis patients were found to be significant. Out of 40 patients, 26 reported side effects and other 14 didn’t have were stable without any side effects. 7 reported Stomachache, 8 reported Dryness of mouth and 11 patients reported other side effects. Among other side effects vomiting and acidity were more commonly reported.


DMARDs, Rheumatoid arthritis, Side effects

Article Details

How to Cite
J. Anantha Lakshmi, K. Ramya Sree, J. Sri Nitya, Prabhath Lakkireddy, N. Anusha, & Yeshwanth Varma. (2023). A prospective study to monitor the side effects associated with disease modifying anti rheumatoid drugs in out-patients of tertiary care hospital. International Journal of Research in Pharmacology & Pharmacotherapeutics, 12(1), 1-7.


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