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Hypertension is caused by increased blood pressure due to increased cardiac output and/or increased peripheral resistance. Hypertension is the leading cause of cardiovascular disease and premature death worldwide. Owing to the widespread use of antihypertensive medications, global mean blood pressure (BP) has remained constant or has decreased slightly over the past four decades. By contrast, the prevalence of hypertension has increased, especially in low- and middle-income countries.This article includes various types of hypertension,different pathological approaches such as based on autonomic nervous system and RAAS mechanism endothelial dysfunction,based on thrombophylia ,based on genetical cause.And it includes risks of getting hypertension and usual clinical manifestations were addressed , and also added diagnostic approaches and management of hypertension which includes both pharmacological and non pharmacological.


Hypertension, Endothelial dysfunction, pharmacological approach

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How to Cite
T. Sri rami reddy, K. Deepika, T. Daveedu, & Y. Sai teja. (2022). A study of pathophysiological approach on hypertension and its comarbidities. International Journal of Research in Pharmacology & Pharmacotherapeutics, 11(3), 145-149.


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