Main Article Content

Abstract

Ayurveda is a traditional system of medicine in India that places an emphasis on the healing properties of plants. One of the plants that is said to be beneficial in Ayurvedic practice is the Bougainvillea glabra. Bougainvillea, has been studied for its purported medical benefits. These include its ability to fight cancer, diabetes, hepatotoxicity, inflammation, hyperlipidemia, bacteria, and ulcers. Therapeutic effects were said to originate from the plant's phytoconstituents, which include alkaloids, flavonoids, glycosides, phenolics, phlobotannins, quinones, saponins, tannins, and terpenoids. Bougainvinones, pinitol, quercetagetin, quercetin, and terpinolene are also significant components that contribute to the healing effects. Databases like Google Scholar,


Science Direct, PubMed, Sci Finder, and Scopus were scoured for articles detailing these newly discovered B. glabra traits. This article provides an assessment of the evidence for and against using B. glabra as a traditional medicinal herb. Keywords- Phytoconstituents, Bougainvillea glabra, Ayurvedic practice, traditional medicinal herb, Therapeutic effects.

Keywords

Bougainvillea Glabra; Phenolic; Phytochemicals; hepatotoxicity.

Article Details

How to Cite
Anurag Singh, Namrata Singh, Ravi Pratap Pandey, & Kapil Vishwash. (2022). Bougainvillea glabra: A Brief Review on Phytochemistry, and Pharmacology. International Journal of Research in Pharmacology & Pharmacotherapeutics, 11(3), 129-134. Retrieved from https://ijrpp.com/ijrpp/article/view/438

References

  1. 1. Howes MJ, Houghton PJ. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behav. 2003;75(3):513-27. doi: 10.1016/s0091-3057(03)00128-x, PMID 12895669.
  2. 2. Gupta R, Bajpai KG, Johri S, Saxena AM. An overview of Indian novel traditional medicinal plants with antidiabetic potentials. Afr J Tradit Complement Altern Med. 2008;5:1-17.
  3. 3. Chun HS, Kim JM, Choi EH, Chang N. Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy. J Med Food. 2008;11(2):246-51. doi: 10.1089/jmf.2007.542, PMID 18598165.
  4. 4. Thiengsusuk A, Chaijaroenkul W, Na-Bangchang K. Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine. Parasitol Res. 2013;112(4):1475-81. doi: 10.1007/s00436-013-3294-6, PMID 23340720.
  5. 5. Warren W. Handy pocket guide to tropical flowers. Singapore: Tuttle Publishing; 2013. p. 64.
  6. 6. Kobayashi KD, McConnell J, Griffis J. Bougainvillea. Ornamentals and flowers. OF-38. Cooperative Extension Service, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa; 2007.
  7. 7. Integrated Taxonomic Information System (ITIS). Bougainvillea spectabilis Willd. taxonomic serial.
  8. 8. No.:895413. VA: Geological Survey; 2016.
  9. 9. Fawad SA, Khalid N, Asghar W, Suleria HAR. In vitro comparative study of Bougainvillea spectabilis.
  10. 10. ’Stand’ leaves and Bougainvillea variegata leaves in terms of phytochemicals and antimicrobial activity. Chinese J Bat Med. 2012;10:441-7.
  11. 11. The plant list. Bougainvillea. The Plant List: A working list of all plant species. Version 1; 2010.
  12. 12. Saikia H, Lama A. Effect of Bougainvillea spectabilis leaves on serum lipids in albino rats fed with high fat diet. Int J Pharm Sci Drug Res. 2011;3:141-5.
  13. 13. Mahajan MM, Dudhgaonkar S, Deshmukh SN. Antidiabetic and hypolipidemic effects of the aqueous leaf extract of Bougainvillea species. Int J Basic Clin Pharmacol. 2015;4:596-7.
  14. 14. Rashid F, Sharif N, Ali I, Sharif S, Nisa FU, Naz S. Phytochemical analysis and inhibitory activity of ornamental plant (Bougainvillea spectabilis). Asian J Plant Sci Res. 2013;3:1-5.
  15. 15. Do LT, Aree T, Siripong P, Pham TN, Nguyen PK, Tip-Pyang S et al. Bougainvinones A-H, peltogynoids from the stem bark of purple Bougainvillea spectabilis and their cytotoxic activity. J Nat Prod. 2016;79(4):939-45. doi: 10.1021/acs.jnatprod.5b00996, PMID 26963142.
  16. 16. Kumar R, Saha P, Kumar Y, Sahana S, Dubey A, Prakash O. A review on diabetes mellitus: Type1 & Type2. World J Pharm Pharm Sci. 2020;9(10):838-50.
  17. 17. Sekhar Niladry DAG, Kumar SG, Debashis P, Shweta S. Management implications for neurotoxic effects associated with antibiotic use. NeuroQuantology. 2022;6(20):304-28. doi: 10.14704/nq.2022.20.6.NQ22034.
  18. 18. Dubey A, Ghosh NS, Rathor VPS, Patel S, Patel B, Purohit D. Sars- COV-2 infection leads to neurodegenerative or neuropsychiatric diseases. Int J Health Sci. 2022;6;Suppl 3:2184-97. doi: 10.53730/ijhs.v6nS3.5980.
  19. 19. Dubey A, Singh Y. Medicinal properties of cinchona alkaloids - A brief review. Asian J Res Pharm Sci. 2021;11(3):224-8. doi: 10.52711/2231-5659.2021.00036.
  20. 20. Yadav K, Sachan A, Kumar S, Dubey A. Techniques for increasing solubility: a review of conventional and new strategies. Asian J Pharm Res Dev. 2022;10(2):144-53.
  21. 21. Kumar A, Dubey A, Singh R. Investigation on anti-ulcer activity of Momordica dioica Fruits in Wistar rat. Int J Res Appl Sci Biotechnol. 2022;9(1):105-11. doi: 10.31033/ijrasb.9.1.12.
  22. 22. Anubhav D, Mamta T, Kumar Vikas S, Kshama S, Akanksha. Investigation of anti-hyperlipidemic activity of vinpocetine in Wistar rat. Int J Pharm Res. 2020;12(2):1879-82. doi: 10.31838/ijpr/2020.12.02.250.
  23. 23. Tiwari A, Singh S, Dubey A, Singh Y. A preliminary study on anti-hyperlipidemic activity of cinnamon oil in Wistar rat. Int J Curr Res. 2021;13(03):16741-5.
  24. 24. Dubey Anubhav TM, Yatendra S, Kumar N, Srivastava K. Investigation of anti-pyretic activity of vinpocetine in Wistar rat. Int J Pharm Res. 2020;12(2):1901-6. doi: 10.31838/ijpr/2020.12.02.254.
  25. 25. Raj A, Tyagi S, Kumar R, Dubey A, Hourasia AC. Effect of isoproterenol and thyroxine in herbal drug used as cardiac hypertrophy. J Cardiovasc Dis Res. 2021:204-17.
  26. 26. Kumar R, Dubey A. Phytochemical investication and heptoprotective evaluation Acacia rubica extract ISONIZED and paracetamol indused animal toxicity. Turk J Physiother Rehabil;32(3).
  27. 27. kumar N, Dubey A, Mishra A, Tiwari P. Formulation and evaluation of metoprolol succinate loaded ethosomal gel for transdermal delivery. JCR; 2020; 7(6). p. 1772-82.
  28. 28. Vukovic N, Kacaniova M, Hleba L, Sukdolak S. Chemical composition of the essential oil of Bougainvillea spectabilis from Montenegro. J Essent Oil Bear Plants. 2013;16(2):212-5. doi: 10.1080/0972060X.2013.794014.
  29. 29. Narayanan CR, Joshi DD, Mujumdar AM, Dhekne VV. Pinitol – A new antidiabetic compound from the leaves of Bougainvillea spectabilis. Curr Sci. 1987;56:139-41.
  30. 30. Jawla S, Kumar Y, Khan MSY. Isolation of phytoconstituents and antihyperglycemic activity of Bougainvillea spectabilis root bark extracts. Lat Am J Pharm. 2013;32:1389-95.
  31. 31. Ikpeme EV, Ekaluo UB, Udensi OU, Ekerette EE, Pius M. Phytochemistry and reproductive activities of male albino rats treated with crude leaf extract of great Bougainvillea (Bougainvillea spectabilis). Asian J Sci Res. 2015;8(3):367-73. doi: 10.3923/ajsr.2015.367.373.
  32. 32. Umamaheswari A, Shreevidya R, Nuni A. In vitro antibacterial activity of Bougainvillea spectabilis leaves extracts. Adv Biol Res. 2008;2:1-5.
  33. 33. Swamy MK, Sudipta KM, Lokesh P, Neeki MA, Rashmi W, Bhaumik SH et al. Phytochemical screening and in vitro antimicrobial activity of Bougainvillea spectabilis flower extracts. Intl J Phytomed 2012. Vol. 4. p. 375-9.
  34. 34. Dhankhar S, Sharma M, Ruhil S, Balhara M, Kumar M, Chillar AK. Evaluation of antimicrobial and antioxidant activities of Bougainvillea spectabilis. Int J Pharm Pharm Sci. 2013;5:178-82.
  35. 35. Hajare CN, Inamdar FR, Patil RV, Shete CS, Wadkar SS, Patil KS et al. Antibacterial activity of the leaves of Bougainvillea spectabilis against E. coli NCIM 2832 and M. aureus NCIM 5021. Int J Pharm Sci Rev Res. 2015;34:194-6.
  36. 36. Adebayo JO, Adesokan AA, Olatunji LA, Buoro DO, Aoladoye AO. Effect of ethanolic extract of Bougainville spectabilis leaves on haematological and serum lipid variables in rats. Biochemist. 2005;17:45-50.
  37. 37. Bhat M, Kothiwale SK, Tirmale AR, Bhargava SY, Joshi BN. Antidiabetic properties of Azardiracta indica and Bougainvillea spectabilis: in vivo studies in murine diabetes model. Evid Based Complement Alternat Med. 2011;2011:Article ID 561625. doi: 10.1093/ecam/nep033, PMID 19389871.
  38. 38. Singh RP, Dr. Dubey V, Dubey A, Dr. Shantanu. Liposomal gels for vaginal drug delivery of amoxicillin trihydrate. Int J Med Res Pharm Sci. 2020;7(8):1-13.
  39. 39. Shweta S. Dwivedi Dr Jyotsana, Tripathi Devika, Verma Priyanka, Ghosh Sekhar Niladry, Dubey Anubhav. NeuroQuantology. 2022. Nanorobotos is an Emerging Technology applicable in the Diagnosis and Treatment of Neuronal and Various Disease;6(20):1081-96. doi: 10.14704/nq.2022.20.6.NQ22100.
  40. 40. RASHEED K, DAKSHINA GUPTA DR, MISHRA AP, DUBEY A. Evaluation of hypoglycemic potential of β escin. Ann Rom Soc Cell Biol. 2021;25(6):13965-75.
  41. 41. ZAIDI S, MEHRA RK, Dr. TYAGI S, DUBEY RKA. Effect of Kalahari cactus extract on Appetitte, body weight and lipid profile in cafeteria diet induced obesity in experimental animal. Ann Rom Soc Cell Biol. 2021;25(6):13976-87.
  42. 42. Kumar N, Dubey A, Mishra A, Tiwari P. Ethosomes: A novel approach in transdermal drug delivery system. Int J Pharm Life Sci. 2020;11(5).
  43. 43. Kshama S, Anubhav D, Mamta T, Anurag D. To evaluate the synergistic effect of pinitol with glimepride in diabetic Wistar rats; 7. 2020;13:2058-62.
  44. 44. Dubey A, Kumar R, Kumar S, Kumar N, Mishra A, Singh Y et al. Review on vinpocetine. Int J Pharm Life Sci. 2020;11(5):6590-7.
  45. 45. Srivastava K, Tiwari M, Dubey A, Dwivedi A. D-pinitol – A Natural phytomolecule and its Pharmacological effect. Int J Pharm Life Sci. 2020;11(5):6609-23.
  46. 46. Dubey A, Tiwari D, Singh Y, Prakash O. PankajSingh. Drug repurposing in Oncology: opportunities and challenges. Int J Allied Sci Clin Res. 2021;9(1):68-87.
  47. 47. Meher CP, Purohit D, Kumar A, Singh R, Dubey A. An updated review on morpholine derivatives with their pharmacological actions. Int J Health Sci. 2022;6;Suppl 3:2218-49. doi: 10.53730/ijhs.v6nS3.5983.
  48. 48. Patnaik S, Purohit D, Biswasroy P, Diab WM, Dubey A. Recent advances for commedonal acne treatment by employing lipid nanocarriers topically. Int J Health Sci. 2022;6;Suppl 8:180-205. doi: 10.53730/ijhs.v6nS8.9671.
  49. 49. -Anubhav Dubey. Tiwari D, Srivastava K, Prakash O, Kushwaha R. A discussion on vinca plant. J Pharmacogn Phytochem. 2020;9(5):27-31.
  50. 50. kumar R, Saha P, Nyarko R, Lokare P, Boateng A, Kahwa I et al. Effect of Covid-19. In: Management of lung cancer disease: a review. Asian Journal of Pharmaceutical Research and Development. Vol. 10(3); 2022. p. 58-64. doi: 10.22270/ajprd.v10i3.113.
  51. 51. Khushnuma R, Dakshina G, Anubhav D, Yatendra S. A review on β-escin. Indian J Med Res Pharm Sci. 2020;8(1):10-6. doi: 10.29121/ijmrps.v8.i1.2020.2.
  52. 52. Anubhav D, Abhay K, Peeyush SJ. Medicinal property of Callistemon viminalis. Int J Pharmacogn Life Sci. 2021;2(2):15-20. doi: 10.33545/27072827.2021.v2.i2a.35.
  53. 53. Pushpa Kumari, Santosh K, Pratap SB, Anubhav D. An Overview on Breast Cancer,International Journal of Medical and all body Health Research www.allmedicaljournal. Vol. 2(3); 2021. Available from: 59-65.www.allmedicaljournal.com.
  54. 54. Priyanka Y, Anubhav D. Formulation and characterization of antiepileptic drug transdermal patch for enhance skin permeation, European. J Biomed Pharm Sci. 2021;8(9):784-90.
  55. 55. Prerna D. Anubhav, Gupta Ratan, nanoparticles: an overview, drugs and cell therapies in. Hematology. 2021;10(1):1487-97.
  56. 56. Raj RS. Shukla Dr. Prashant, Dubey Anubhav, Delivery of repurposed drugs for cancer: opportunities and challenges,European. J Pharm Med Res. 2021;8(9):271-81.
  57. 57. Anubhav SahaPD. Kumar Dr. Sanjay,Kumar Roshan, evaluation of enzyme producing K. pneumoniae and their susceptibility to other antibiotics. Int J Innov Sci Res Technology. 2022;7(5).
  58. 58. Bihari PandaB, Patnaas S, Debashish P, Shubhashree D, Anubhav D. Impact of sodium starch glycolate on Physico-chemical characteristics of mouth dissolving film of fexofenadine. NeuroQuantology. 2022;20(6):7604-13. doi: 10.14704/nq.2022.20.6.NQ22759.
  59. 59. Jawla S, Kumar Y, Khan MSY. Hypoglycemia activity of Bougainvillea spectabilis stem bark in normal and alloxaninduced diabetic rats. Asian Pac J Trop Biomed. 2012;2(2):S919-23. doi: 10.1016/S2221-1691(12)60337-2.
  60. 60. Jawla S, Kumar Y, Khan MSY. Isolation of antidiabetic principle from Bougainvillea spectabilis Willd. (Nyctaginaceae) stem bark. Trop J Pharm Res. 2013;12(5):761-5. doi: 10.4314/tjpr.v12i5.15.
  61. 61. Mishra N, Joshi S, Tandon VL, Munjal A. Evaluation of antifertility potential of aqueous extract of Bougainvillea spectabilis leaves in swiss albino mice. Int J Pharm Sci Drug Res. 2009;1:19-23.
  62. 62. Hembrom AR, S P, Singh VN. Selective and directional influence of Bougainvillea spectabilis on anodic electrophoretic proteins and m-isozymes of LDH in semen of mice in relation to fertility control. Int Res J Pharm. 2014;5(7):576-7. doi: 10.7897/2230-8407.0507116.
  63. 63. Chaires-Martinez L, Monroy-Reyes E, Bautista-Bringas A, Jimenez-Avalos HA, Sepulveda-Jimenez G. Determination of radical scavenging activity of hydroalcoholic and aqueous extracts from Bauhinia divaricata and Bougainvillea spectabilis using the DPPH assay. Pharmacogn Res. 2009;1:238-44.