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Abstract

Plectranthus vettiveroides is an epiphytic orchid used extensively by the tribes of Karnataka in various diseases such as heart disease, leukoderma, skin allergy and rheumatism. It is used both internally and as an external application.  This study aims to evaluate analgesic and anti-inflammatory activities of ethanolic extract of P.vettiveroides leaves powder in experimental animals.  Shade-dried leaves were pulverized into fine powder. The analgesic activity of test drug was evaluated with tail-flick response and formalin-induced paw licking and anti-inflammatory activity with carrageenan-induced paw edema and formaldehyde-induced edema in Charles Foster albino rats. Statistically, the values were assessed with one-way analysis of variance followed by Dunnett's multiple t- tests and Student's t-test for paired and unpaired data. Administration of P.vettiveroides leaves powder showed significant increase in tail-flick response at 30 min (50.64%), at 60 min (106.13%), 120 min (80.01%), and 180 min (48.06%). Test drug produced no significant inhibition of carrageenan-induced paw edema at 1 h (36.14%) and 5 h (14.56%) compared to control group and did not produced any effect in formalin-induced edema. The present study concluded that the test drug has central analgesic activity against radiant heat-induced pain, moderate anti-inflammatory activity against carrageenan-induced acute inflammation.

Keywords

Analgesic Anti-inflammatory Carrageenan P.vettiveroides Formalin

Article Details

How to Cite
Mohammed Abdul Nazeer, Gayathri Nallathambi, & Jeevanandham Somasundaram. (2021). Analgesic and anti-inflammatory activities of leaves of plectranthus vettiveroides. International Journal of Research in Pharmacology & Pharmacotherapeutics, 9(3), 227-233. https://doi.org/10.61096/ijrpp.v9.iss3.2020.227-233