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Abstract

This study was done to test the neuroprotective effects of Tecoma stans against brain ischemia/reperfusion caused oxidative stress in the rats. The global cerebral ischemia was generated in male albino Wistar rats by occluding the bilateral carotid arteries for 30 min followed by 1 h and 4 h reperfusion. The levels of malondialdehyde (MDA), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-s-transferase (GST), and hydrogen peroxide (H 2 O 2 ) activity, as well as brain water content, were examined at various periods after reperfusion. Ischemic alterations were preceded by a rise in MDA and hydrogen peroxide concentrations, followed by a reduction in GPx, GR, and GST activity. Ischemia-induced oxidative stress was greatly reduced after treatment with T.stans. In the groups pre-treated with methanolic extract (250 and 500 mg/kg, administered orally in single and double doses/day for 10 days), T.stans administration dramatically reversed and restored to near normal levels in a dose-dependent manner. In the ischemia reperfusion animals, T.stans reversed the cerebral water content. The neurodegenaration also confirmed by the histopathological changes in the cerebral-ischemic animals. The findings from the present investigation reveal that T.stans protects neurons from global cerebral-ischemic injury in rat by attenuating oxidative stress.

Keywords

Brain edema global cerebral ischemia histopathology oxidative stress Tecoma stans

Article Details

How to Cite
Sudhanshu Bansal, Sandeep Singh Chouhan, Gurpreet Singh Multani, Shivam Choudghal, Gurinder kaur, & Dharampreet Singh. (2022). Neuroprotective activity of tecoma stans on cerebral ischemia/reperfusion induced oxidative stress in rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 11(1), 16-26. https://doi.org/10.61096/ijrpp.v11.iss1.2022.16-26

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