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Abstract
We will address a concise summary of pathophysiology, signs & symptoms, implications, diagnosis, and treatments in this article. The regulation of water metabolism is key in this condition. A prominent problem of water regulation is diabetes insipidus, which is characterized by extreme fluid loss from the kidney. This chapter will go over the many types of diabetes insipidus, with a focus on central diabetes insipidus and nephrogenic diabetes insipidus. The following article provides a basic understanding of the pathophysiology of both type1 and type 2 diabetic Mellitus.
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References
- 1. Lu HA. Diabetes Insipidus. Adv Exp Med Biol. 2017;969:213-225. doi: 10.1007/978-94-024-1057-0_14. PMID: 28258576.
- 2. Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004 Apr-Jun;27(2):113-25. doi: 10.1097/00002727-200404000-00003. PMID: 15137354.
- 3. Gordge MP, Williams DJ, Huggett NJ, Payne NN, Neild GH. Loss of biological activity of arginine vasopressin during its degradation by vasopressinase from pregnancy serum. Clin Endocrinol (Oxf). 1995 Jan;42(1):51-8. doi: 10.1111/j.1365-2265.1995.tb02598.x. PMID: 7889632.
- 4. Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004 Apr-Jun;27(2):113-25. doi: 10.1097/00002727-200404000-00003. PMID: 15137354.
- 5. Bockenhauer D, Bichet DG. Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus. Nat Rev Nephrol. 2015 Oct;11(10):576-88. doi: 10.1038/nrneph.2015.89. Epub 2015 Jun 16. PMID: 26077742.
- 6. Schernthaner-Reiter MH, Stratakis CA, Luger A. Genetics of Diabetes Insipidus. Endocrinol Metab Clin North Am. 2017 Jun;46(2):305-334. doi: 10.1016/j.ecl.2017.01.002. Epub 2017 Feb 28. PMID: 28476225.
- 7. Liu SY, Tung YC, Lee CT, Liu HM, Peng SF, Wu MZ, Kuo MF, Tsai WY. Clinical characteristics of central diabetes insipidus in Taiwanese children. J Formos Med Assoc. 2013 Oct;112(10):616-20. doi: 10.1016/j.jfma.2013.06.019. Epub 2013 Aug 2. PMID: 23916565.
- 8. Robinson AG. DDAVP in the treatment of central diabetes insipidus. N Engl J Med. 1976 Mar 4;294(10):507-11. doi: 10.1056/NEJM197603042941001. PMID: 1250255.
- 9. Burrow GN, Wassenaar W, Robertson GL, Sehl H. DDAVP treatment of diabetes insipidus during pregnancy and the post-partum period. Acta Endocrinol (Copenh). 1981 May;97(1):23-5. doi: 10.1530/acta.0.0970023. PMID: 7223315.
- 10. Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004 Apr-Jun;27(2):113-25. doi: 10.1097/00002727-200404000-00003. PMID: 15137354.
References
1. Lu HA. Diabetes Insipidus. Adv Exp Med Biol. 2017;969:213-225. doi: 10.1007/978-94-024-1057-0_14. PMID: 28258576.
2. Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004 Apr-Jun;27(2):113-25. doi: 10.1097/00002727-200404000-00003. PMID: 15137354.
3. Gordge MP, Williams DJ, Huggett NJ, Payne NN, Neild GH. Loss of biological activity of arginine vasopressin during its degradation by vasopressinase from pregnancy serum. Clin Endocrinol (Oxf). 1995 Jan;42(1):51-8. doi: 10.1111/j.1365-2265.1995.tb02598.x. PMID: 7889632.
4. Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004 Apr-Jun;27(2):113-25. doi: 10.1097/00002727-200404000-00003. PMID: 15137354.
5. Bockenhauer D, Bichet DG. Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus. Nat Rev Nephrol. 2015 Oct;11(10):576-88. doi: 10.1038/nrneph.2015.89. Epub 2015 Jun 16. PMID: 26077742.
6. Schernthaner-Reiter MH, Stratakis CA, Luger A. Genetics of Diabetes Insipidus. Endocrinol Metab Clin North Am. 2017 Jun;46(2):305-334. doi: 10.1016/j.ecl.2017.01.002. Epub 2017 Feb 28. PMID: 28476225.
7. Liu SY, Tung YC, Lee CT, Liu HM, Peng SF, Wu MZ, Kuo MF, Tsai WY. Clinical characteristics of central diabetes insipidus in Taiwanese children. J Formos Med Assoc. 2013 Oct;112(10):616-20. doi: 10.1016/j.jfma.2013.06.019. Epub 2013 Aug 2. PMID: 23916565.
8. Robinson AG. DDAVP in the treatment of central diabetes insipidus. N Engl J Med. 1976 Mar 4;294(10):507-11. doi: 10.1056/NEJM197603042941001. PMID: 1250255.
9. Burrow GN, Wassenaar W, Robertson GL, Sehl H. DDAVP treatment of diabetes insipidus during pregnancy and the post-partum period. Acta Endocrinol (Copenh). 1981 May;97(1):23-5. doi: 10.1530/acta.0.0970023. PMID: 7223315.
10. Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004 Apr-Jun;27(2):113-25. doi: 10.1097/00002727-200404000-00003. PMID: 15137354.