Management of the ADRs experienced during the Hospital stay

Abstract

This is a prospective observational study done for a period of three years from March 2015 to March 2015 at the inpatient block of multispecialty hospitals, Patients Visited or admitted in Hospital due to ADRs Hyderabad, Patients who visited the Hospital were reviewed on daily basis and monitored for ADRs. Patient’s demographic details are collected and documented. Suspected ADRs were assessed by using standard algorithms. It includes all the information such as name, age, sex, reason for admission, brief description of reaction, relevant past history of medication, the onset and severity of the ADR experienced the impact of ADR on the treatment and drug involved, dose of the drug, route and frequency time. All the suspected ADRs were evaluated for their causality using WHO Probability Scale, Naranjo’s Algorithm, and the Karch and Lasagna scale Severity assessment was done using the Hartwig et al. Scale. Preventability of an ADR is determined by using Shumock et al. criteria. Predictability of an ADR is also determined by using criteria’s. Results and Discussion: Among the 383 cases, 592 adverse drug reactions were identified, which shows the probability of multiple adverse drug reactions in a single patient. Among age groups adults 52.74% were predominant over geriatric 36.55% and children 10.70% in terms of prevalence, while males have higher risk to develop adverse drug reactions among adults and geriatrics, and in Children both the genders have high risk in developing adverse drug reactions and showing 1.69 times higher risk for males to develop adverse drug reactions. Among the 383 cases documented predominance of adverse drug reactions was observed in patients belonging to urban area 59.26%.