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Abstract

The present study was carried out to evaluate the anticancer property of ethanol extract of Plectranthusvettiveroides leaves against Ehrlich ascites carcinoma in Swiss albino mice. The leaves powder was subjected to continuous hot extraction using ethanol and cold maceration by water to get Ethanol and Aqueous extracts, respectively. Identification of the chemical constituents of plant extract was determined by standard procedures. The in vivo anticancer study was determined in mice using Ehrlich ascites carcinoma cell line. The extract's in vivo cytotoxic impact was determined by measuring mean survival time, haematological parameters, cell count, tumour weight, and antioxidant enzyme activities such as lipid peroxidase, reduced glutathione, superoxide dismutase, and catalase. The crude extract indicated the presence of several chemical groups such as alkaloids, saponins, steroids, flavonoids, and glycosides during phytochemical screening. The extract resulted in a substantial increase in life duration as well as a reduction in the number of cancer cells, tumour weight, and tumour volume. At doses of 200 and 400 mg/kg, the extract was found to have a protective impact on the hemopoietic system. Serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, and alkaline phosphatase levels were significantly reduced by the extract. Lipid peroxidation was avoided, and antioxidant enzymes were restored, thanks to the extract. The ethanol extract of Plectranthus  vettiveroides demonstrated a substantial (p0.001) in vivo cytotoxic impact when compared to the tumour control group, according to the findings.

Keywords

Plectranthus vettiveroides In vivo Cytotoxicity studies EAC cell line

Article Details

How to Cite
Catherine Immaculate Gunaseelan, & Akilandeswari. S. (2021). Evaluation of in vivo anticancer activity of plectranthus vettiveroides against ehrlich ascites carcinoma in swiss albino mice. International Journal of Research in Pharmacology & Pharmacotherapeutics, 10(3), 279-285. Retrieved from https://ijrpp.com/ijrpp/article/view/402

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