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Abstract

This study is planned to investigate the effect of Tecomastans methanolic extract (METS) on proteinuria, glucosuria,
and some other biochemical parameters in adriamycin-induced renal impairment in rats. Ether anesthetized rats
received three intravenous injections (days 0, 14, and 28) of 2 mg/kg body weight of adriamycin. Repeated doses of
the extract (0, 50, and 68 mg/kg b.w.) and losartan (10 mg/kg b.w.) were administered orally once daily, for 6
weeks, to these rats. Kidney functions were assessed through biochemical parameters. METS decreased proteinuria
and also the urinary excretion of creatinine, glucose, and urea significantly in diseased rats. A decrease in serum
levels of creatinine, urea, potassium, alkaline phosphatase, conjugate bilirubin, and alanine transaminase level was
also recorded in nephropathic rats, but plasma levels of uric acid and glucose remained unchanged. Moreover, the
plant extract markedly (P < 0.05) increased plasma sodium and decreased (P < 0.01) the urinary sodium and
potassium levels. The results indicated that the treatment with the methanolic extract of T.stans may improve
proteinuria and all other symptoms due to adriamycin-induced nephropathy and, more than losartan, could
ameliorate kidney and liver functions. T.stans could be a potential source of new oral antinephropathic drug

Keywords

:Adriamycin Antioxidant effect Tecomastans Methanolic extract Nephropathy Rat

Article Details

How to Cite
A. Kavidha, Dr. N. Sriram, & Ebenezer David. (2021). Effect of methanolic extract of tecomastans on metabolic parameters in adriamycin-induced renal impairment in rats . International Journal of Research in Pharmacology & Pharmacotherapeutics, 10(1), 23-32. Retrieved from https://ijrpp.com/ijrpp/article/view/4