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Aug 19, 2021
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Aug 19, 2021
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Abstract

Background: In diabetes mellitus patients, there is an increased susceptibility to lipid peroxidation which increases the incidence of atherosclerosis and major complication of DM. Antioxidants supplementation defends free radical induced damage and thus decrease further complications.


Objective: To evaluate the efficacy and safety of metformin versus metformin with vitamin C and E on non-glycaemic parameters in newly diagnosed type 2 diabetes mellitus.


Methods: 60newly diagnosed type 2 diabetes patients were randomized into two groups of 30 in each to receive Metformin (500mg BD) alone in group A versus Metformin (500mg BD) + Vitamin C (500mg OD) + Vitamin E (400mg OD) in group B for 12 weeks. Efficacy was measured by improvement in non-glycaemic parameters (Hb%, Lipid profile) at week 12 from baseline. Safety was assessed by monitoring treatment emergent adverse effects.


Results: The baseline characteristics were comparable between the two groups. There is a significant improvement in haemoglobin percentage and significant decrease in lipid levels was observed in group B from baseline to week 12, but the difference was not statistically significant between the two groups (p>0.05). No significant adverse effects were noted.


Conclusion: Both the groups are effective in improving both haemoglobin percentage and lipid profile in supplementation of vitamins along with Metformin as compared to Metformin alone with no significant adverse effect. Hence, daily consumption of vitamins may be beneficial in decreasing lipids in patients with T2DM and thus reducing the risk of complications.

Keywords

Diabetes mellitus Oxidative stress Metformin Vitamin C Vitamin E

Article Details

How to Cite
Prashanth B V, Yashaswini P, & Geetha A. (2021). A comparative study of efficacy and safety of anti-oxidants as an add-on therapy to metformin on non-glycemic parameters in newly diagnosed type 2 diabetes mellitus patients. International Journal of Research in Pharmacology & Pharmacotherapeutics, 10(3), 249-256. https://doi.org/10.61096/ijrpp.v10.iss3.2021.249-256
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References

  1. [1]. Rang HP, Dale MM, Ritter JM. The control of blood glucose & drug treatment of diabetes mellitus. Rang and Dale's pharmacology. 7th ed. Edinburgh: Elsevier/Churchill Livingstone; 2012.p.378.
  2. [2]. Introduction: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018; 41: S1-S2. Available from: http://care.diabetesjournals.org/content/41/Supplement_1[Accessed 07 Nov 2018].
  3. [3]. Powers AC, D’Alessio D. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycaemia. In: Goodman L, Goodman L, Brunton L, Lazo J, Parker K, editors. The pharmacological basis of therapeutics. 12thed. New York: McGraw-Hill; 2011.p.1258.
  4. [4]. Johansen J, Harris A, Rychly D, Ergul A. Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice. CardiovasDiabetol. 2005; 4(1):5.
  5. [5]. Ahmad N, Rahmat A, Mushtaq A, Nadia M. Role of antioxidant in oxidative stress and diabetes mellitus. Journal of Pharmacognosy and Phytochemistry. 2015; 3(6):217-220.
  6. [6]. Ayepola O, Brooks N, Oguntibeju O. Oxidative Stress and Diabetic Complications: The Role of Antioxidant Vitamins and Flavonoids. Antioxidant-Antidiabetic Agents and Human Health. 2014; 27-58.
  7. [7]. Kathore VR, Bansode DG. The effect of vitamin c on fasting blood glucose level and lipid profile in type-2 Diabetes mellitus patients. International Journal of Recent Trends in Science and Technology. 2014; 16(3):585-590.
  8. [8]. El-Aal AA, El-Ghffar EAA, Ghali AA, Zughbur MR, Sirdah MM. The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2018;12(4):483–9.
  9. [9]. Hamed AT, Zinati SMA, Swirky AA. The Effect of Vitamin C Alone or in Combination with Vitamin E on Fasting Blood Glucose, Glycosylated Hemoglobin and Lipid Profile in Type 2 Diabetic Patients (Gaza Strip). Jordan Journal of Pharmaceutical Sciences. 2016;9(1):12-24.
  10. [10]. Gillani SW, Sulaiman SAS, Abdul MIM, Baig MR. Combined effect of metformin with ascorbic acid versus acetyl salicylic acid on diabetes-related cardiovascular complication; a 12-month single blind multicenter randomized control trial. Cardiovascular Diabetology. 2017; 16(1):103-116.
  11. [11]. Bhatt JK, Thomas S, Mj N. Effect of Oral Supplementation of Vitamin C on Glycemic Control and Lipid Profile in patients with Type 2 Diabetes Mellitus. 2012; 4(2):524-527.
  12. [12]. Rafighi Z, Arab S, Yusof MR, Shiva A. The Effect of Vitamin C and E on Lipid Profile in Type 2 Diabetes Mellitus Patients. Global Journal of Health Science. 2011; 3(2):69-74.
  13. [13]. Nath RK, Akhter M, Sarker KR, Rahman MR, Chowdhury SS, Ishrat R. Effect of Vitamin C on Blood Glucose & Serum Lipids in Type 2 Diabetes Patients. KYAMC Journal. 2013; 4(1):337-340.
  14. [14]. Ardekani AM, Ardekani SA. Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients. Indian J Med Res. 2007; 4:471-474.