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Background: In diabetes mellitus patients, there is an increased susceptibility to lipid peroxidation which increases the incidence of atherosclerosis and major complication of DM. Antioxidants supplementation defends free radical induced damage and thus decrease further complications.

Objective: To evaluate the efficacy and safety of metformin versus metformin with vitamin C and E on non-glycaemic parameters in newly diagnosed type 2 diabetes mellitus.

Methods: 60newly diagnosed type 2 diabetes patients were randomized into two groups of 30 in each to receive Metformin (500mg BD) alone in group A versus Metformin (500mg BD) + Vitamin C (500mg OD) + Vitamin E (400mg OD) in group B for 12 weeks. Efficacy was measured by improvement in non-glycaemic parameters (Hb%, Lipid profile) at week 12 from baseline. Safety was assessed by monitoring treatment emergent adverse effects.

Results: The baseline characteristics were comparable between the two groups. There is a significant improvement in haemoglobin percentage and significant decrease in lipid levels was observed in group B from baseline to week 12, but the difference was not statistically significant between the two groups (p>0.05). No significant adverse effects were noted.

Conclusion: Both the groups are effective in improving both haemoglobin percentage and lipid profile in supplementation of vitamins along with Metformin as compared to Metformin alone with no significant adverse effect. Hence, daily consumption of vitamins may be beneficial in decreasing lipids in patients with T2DM and thus reducing the risk of complications.


Diabetes mellitus Oxidative stress Metformin Vitamin C Vitamin E

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How to Cite
Prashanth B V, Yashaswini P, & Geetha A. (2021). A comparative study of efficacy and safety of anti-oxidants as an add-on therapy to metformin on non-glycemic parameters in newly diagnosed type 2 diabetes mellitus patients. International Journal of Research in Pharmacology & Pharmacotherapeutics, 10(3), 249-256. Retrieved from


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