Article Sidebar

Submitted
Jun 22, 2021
Published
Jun 22, 2021
Download
PDF
Statistic
Read Counter : 97 Download : 77

Main Article Content

Abstract

The goal of this study was to see if hydroalcoholic extract of leaves of Plectranthus vettiveroides(HEPV) might help rats with glycerol-induced acute renal failure (ARF). The rats were given a single intramuscular injection of hypertonic glycerol (50 percent v/v; 8 ml/kg) to induce rhabdomyolytic ARF, and the animals were euthanized after 24 hours. The degree of renal damage was determined using plasma creatinine, blood urea nitrogen, creatinine clearance, and histological investigations. In a dose-dependent manner, pre-treatment with HEPV (125 and 250 mg/kg p.o. twice daily for 3 days) substantially reduced hypertonic glycerol-induced renal impairment. To investigate the mechanism of HEPV's renoprotective effects, researchers used BADGE (Bisphenol-A-diglycidyl ether) (30 mg/kg), a PPAR antagonist, and N(omega)-nitro-l-arginine-methyl ester (L-NAME) (10, 20, and 40 mg/kg), a nitric oxide synthase inhibitor. The therapeutic effects of HEPV in glycerol-induced renal impairment were reversed when BADGE (30 mg/kg) and L-NAME (40 mg/kg) were given. The hydroalcoholic extract of Plectranthus vettiveroides leaves has the ability to reduce myoglobinuric renal failure, and its renoprotective actions are mediated via activation of the PPAR and nitric oxide-dependent signalling pathways.

Keywords

Plectranthus vettiveroides ARF, (PPAR)-γ BADGE

Article Details

How to Cite
Dr. Kavitha Rajesh, Kannan Raman, & G. Gnana Jebaslin. (2021). Effect of hydroalcoholic Plectranthus vettiveroides in glycerol-induced acute renal failure in rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 10(2), 133-140. https://doi.org/10.61096/ijrpp.v10.iss2.2021.133-140
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. [1]. Parikh CR, McSweeney P, Schrier RW. Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant. Kidney Int 2005; 67:1999-2005.
  2. [2]. Zurovsky Y. Models of glycerol-induced acute renal failure in rats. J Basic Clin PhysiolPharmacol1993; 4:213-2.
  3. [3]. Khan FY. Rhabdomyolysis: A review of the literature. Neth J Med 2009; 67:272-83.
  4. [4]. R. Santhan Nehru Narkilli, N. Sriram, Kameshwaran.S, Elavarasan.N, Asok Kumar.DS, Priyanka.V. Analgesic, anti-inflammatory & CNS depressant activity of methanolic extract of Plectranthus vettiveroides stem bark in mice. / Int. J. of Res. in Pharmacology &Pharmacotherapeutics Vol-9(4) 2020 [274-278].
  5. [5]. S. Kameshwaran, K.Abhenaya, R.Manivannan, N.Elavarasan, D.S.Asok Kumar, J. Priya and V.Priyanka. Analysis of Inhibitory Propensity and Percentage Inhibition of Tecoma stans and Plectranthus vettiveroidesLeaves against Escherichia coli ESBL Enzyme in Namakkal District Broilers, Tamil Nadu, India. Journal of Pharmacy and Pharmacology, 8 (2020) 172-177. doi: 10.17265/2328-2150/2020.06.003.
  6. [6]. R.Sundara Ganapathy, S.Mohan, S.Kameshwaran, C.Dhanapal, Hepatoprotective activity of Plectranthus vettiveroidesagainst paracetamol and D Galactosamine induced hepatic toxicity. International Journal of Pharmacy & Therapeutics, 6(4), 2015, 242-246.
  7. [7]. R.Sundara Ganapathy, S.Mohan, S.Kameshwaran, C.Dhanapal, In vitro anti-cancer and In vitro antioxidant potency of roots of hydro alcoholic extract of Plectranthus vettiveroides, International Journal of Phytopharmacology. 6(4), 2015, 246-254.
  8. [8]. S.Kamaeshwaran, J.Priyadharshini, K.Saranya, C.sudha, P.J.Sandra, K.S.Swathy. Phytochemical screening and acute toxicity study of hydro alcoholic extract of Plectranthus vettiveroides.Int. J. Pharm. Res. Sci., 2014, 02(2), 126-134.
  9. [9]. Kiss E, Popovic ZV, Bedke J, Adams J, Bonrouhi M, Babelova A, et al. Peroxisome proliferator-activated receptor (PPAR) gamma can inhibit chronic renal allograft damage. Am J Pathol2010; 176:2150-62.
  10. [10]. Doi S, Masaki T, Arakawa T, Takahashi S, Kawai T, Nakashima A, et al. Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury. Transplantation 2007; 84:207-13.
  11. [11]. Itoh H, Doi K, Tanaka T, Fukunaga Y, Hosoda K, Inoue G, et al. Hypertension and insulin resistance: Role of peroxisome proliferator activates receptor gamma. Clin Exp PharmacolPhysiol1999; 26:558-60.
  12. [12]. Li Y, Qi Y, Huang TH, Yamahara J, Roufogalis BD. Pomegranate flower: A unique traditional antidiabeteic medicine with dual PPAR-α/γ activator properties. Diabetes ObesMetab2007; 10:1326-463.
  13. [13]. Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, et al. Anti-diabetic action of Punicagranatum flower extract: Activation of PPAR-gamma and identification of an active component. ToxicolAppl Pharmacol2005; 207:160-9.
  14. [14]. Huang TH, Yang Q, Harada M, Li GQ, Yamahara J, Roufogalis BD, et al. Pomegranate flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats: Modulation of cardiac endothelin-1 and nuclear factor-kappaB pathways. J Cardiovasc Pharmacol2005; 46:856-62.
  15. [15]. Yousefipour Z, Oyekan A, Newaz M. Interaction of oxidative stress, nitric oxide and peroxisome proliferator activated receptor gamma in acute renal failure. PharmacolTher2010; 125:436-45.
  16. [16]. Kone BC, Baylis C. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am J Physiol 1997;272: F561-78.
  17. [17]. Valdivielso JM, López-Novoa JM, Eleno N, Barriocanal PF. Role of glomerular nitric oxide in glycerol-induced acute renal failure. Can J PhysiolPharmacol2000; 78:476-82.
  18. [18]. Chander V, Chopra K. Molsidomine, a nitric oxide donor and l-arginine protects against rhabdomyolysis-induced myoglobinuric acute renal failure. BiochimBiophys Acta 2005; 1723:208-14.
  19. [19]. De Nigris F, Williams-Ignarro S, Sica V, Lerman LO, D'Armiento FP, Byrns RE, et al. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc Res 2007; 73:414-23.
  20. [20]. De Nigris F, Balestrieri ML, Williams-Ignarro S, D'Armiento FP, Fiorito C, Ignarro LJ, et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide 2007; 17:50-4.
  21. [21]. Ibrahim M, Luchese C, Pinton S, Roman SS, Hassan W, Nogueira CW, et al. Involvement of catalase in the protective effect of binaphthyl diselenide against renal damage induced by glycerol. Exp ToxicolPathol2010; 63:331-5.
  22. [22]. Rinwa P, Kaur B, Jaggi AS, Singh N. Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia. NaunynSchmiedebergs Arch Pharmacol2010; 381:529-39.
  23. [23]. Jain V, Jaggi AS, Singh N. Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats. Pharmacol Res 2009; 59:385-92.
  24. [24]. Newaz M, Yousefipour Z, Oyekan A. Role of PPAR-g on the pathogenesis and vascular changes in glycerol-induced acute renal failure. Pharmacol Res 2006; 54:234-40.
  25. [25]. Aydogdu N, Atmaca G, Yalcin O, Taskiran R, Tastekin E, Kaymak K. Protective effects of L-carnitine on myoglobinuric acute renal failure in rats. Clin Exp PharmacolPhysiol2006; 33:119-24.
  26. [26]. Liang C, Ren Y, Tan H, He Z, Jiang Q, Wu J, et al. Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products. Br J Pharmacol2009; 158:1865-73.
  27. [27]. Ptasinska A, Wang S, Zhang J, Wesley RA, Danner RL. Nitric oxide activation of peroxisome proliferator activated receptor gamma through a p38 MAPK signaling pathway. FASEB J 2007; 21:952-61.
  28. [28]. Borniquel S, Jansson EA, Cole MP, Freeman BA, Lundberg JO. Nitrated oleic acid up-regulates PPARγ and attenuates experimental inflammatory bowel disease. Free RadicBiol Med 2010; 48:499-505