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Abstract
The purpose of this study is based upon synthesis of a series of 1,4-disubstituted piperazine derivatives through two step reaction. This protocol involves the formation of various acid chlorides (3a-3j) through reaction of substituted acid with thionyl chloride in the presence of a drop of dimethyl formamide as a catalyst. The second step involves the reaction of compounds (3a-3j) with methyl piperazine, affording target compounds (5a-5j).The structures of target compounds were elucidated from the data of the different spectral methods of analysis. In addition, a mass spectrum, for a representative example, was carried out where the expected fragmentation pattern is in accordance with the structure of the proposed compound. The anthelmintic activity of the synthesized derivatives (5a-5j) was investigated in vitro against Eisenia fetida. All the investigational compounds (5a-5j) exhibited promising anthelmintic activity at minimal dose of 5mg/ml in comparison with reference drug Piperazine citrate.
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References
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- [2]. Rashood KA and Abdel-Aziz H A, Molecule. 15, 2010, 3775.
- [3]. Tonelli M, Simone M, Pagliett G, Pricl S, Tasso B, Novelli F and Boidov SF,Bioorganic Medicinal Chemistry. 18, 2010, 2937.
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- [6]. Baskar L, Papiya M, Sasmal D, Ganguly and Simon SJ, “In Vitro Anthelmintic Activity of Some 1-Substituted Imidazole Derivatives.” Acta Parasitologica Globalis. 2(1), 2011, 01-05.
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- [8]. Velingkar VS, Dandekar VD and Murugananthan K, “Synthesis and Pharmacological Evaluation of Some Novel Potent Type II Antidiabetic Agents.” International Journal of Pharmacy and Pharmaceutical Sciences, 1, 2009, 149-158.
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References
[1]. Joshi KC, Jain R, Dandia A and Sharma K, Journal of Fluorine Chemistry. 56, 1992, 1.
[2]. Rashood KA and Abdel-Aziz H A, Molecule. 15, 2010, 3775.
[3]. Tonelli M, Simone M, Pagliett G, Pricl S, Tasso B, Novelli F and Boidov SF,Bioorganic Medicinal Chemistry. 18, 2010, 2937.
[4]. Sharma K and Jain R, “Synthesis, reactions and anthelmintic activity of 1-[benzimidazole-2-yl]-4-formyl-3-[2׳(-substituted indole-3-yl]pyrazoles.” Indian Journal of Chemistry. 51, 2012, 1462-1469.phenyl)
[5]. Deshmukh S.U, B.Pharm Thesis, “Synthesis, chemical characterization and antimicrobial activity of some new benzimidazole derivatives” Rajiv Gandhi University, 2011.
[6]. Baskar L, Papiya M, Sasmal D, Ganguly and Simon SJ, “In Vitro Anthelmintic Activity of Some 1-Substituted Imidazole Derivatives.” Acta Parasitologica Globalis. 2(1), 2011, 01-05.
[7]. Gbolade AA and Adeyemi AA, “Anthelmintic activities of three medicinal plants from Nigeria.” Fitoterapia. 79, 2008, 223-225.
[8]. Velingkar VS, Dandekar VD and Murugananthan K, “Synthesis and Pharmacological Evaluation of Some Novel Potent Type II Antidiabetic Agents.” International Journal of Pharmacy and Pharmaceutical Sciences, 1, 2009, 149-158.
[9]. Vogel’s Textbook of Practical Organic Chemistry; Furniss BS., Hannaford AJ., Smith PWG and Tatchell AR., 4th Edn; Pearson publication, 1978, 138.