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Abstract

Dengue is a viral disease that at present affects an enormous number of people in over 125 countries and is conscientious for a sizable number of deaths. There is no antiviral chemotherapy or vaccine for dengue virus and management of the disease is done on supportive measures, so various treatments are being investigated. Studies have indicated that the juice of the leaves of the Carica papaya plant from the family Caricaceae could help to increase the platelet levels in these patients. This review explains some of the published studies on this topic. Although many of the studies and case reports published in literature lack adequate information, some of the studies do raise the possibility that this treatment could be an important option in the future. Further large scale studies could establish the usefulness or ineffectiveness of this natural product in the treatment of dengue.

Keywords

Dengue fever Newer therapy Carica papaya

Article Details

How to Cite
Arun Mathew, Venkat Paluri, Venkateswaramurthy N, & Sambath kumar R. (2021). A review of newer therapy in dengue fever. International Journal of Research in Pharmacology & Pharmacotherapeutics, 5(2), 170-177. https://doi.org/10.61096/ijrpp.v5.iss2.2016.170-177

References

  1. [1]. Chaudhary R, Khetan D, Sinha S, Sinha P, Sonker A, Pandey P, et al. Transfusion support to Dengue patients in a hospital based blood transfusion service in north India. Transfus Apher Sci 2006; 35: 239-44.
  2. [2]. Kharya G, Yadav SP, Katewa S, Sachdeva A. Management of severe refractory thrombocytopenia in dengue hemorrhagic fever with intravenous anti-D immune globulin. Pediatr Hematol Oncol 2011; 28: 727-32.
  3. [3]. Shrivastava R, Nagar R, Ravishankar GA, Upreti RK, Chaturvedi UC Effect of pretreatment with chromium picolinate on haematological parameters during dengue virus infection in mice. Indian J Med Res 2007; 126: 440-6.
  4. [4]. Jain M, Ganju L, Katiyal A, Padwad Y, Mishra KP, Chanda S, et al. Effect of Hippophae rhamnoides leaf extract against dengue virus infection in human blood-derived macrophages. Phytomedicine 2008; 15: 793-9.
  5. [5]. WHO. 2. Dengue: Guidelines for diagnosis, treatment, prevention, and control in sub-Saharan Africa and 13 countries in South America. Geneva: World Health Organization; 2009, 2012.
  6. [6]. Hynes NA. Dengue: A reemerging concern for travelers. Cleve Clin J Med. 2012;79:474–82.
  7. [7]. Hottz E, Tolley ND, Zimmerman GA, Weyrich AS, Bozza FA. Platelets in dengue infection. Drug Discov Today Dis Mech. 2011;8: E33–8.
  8. [8]. Meneses R, Ocazionez RE, Martinez JR, Stashenko EE. Inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro. Ann Clin Microbiol Antimicrob 2009; 8: 8.
  9. [9]. Betancur-Galvis LA, Saez J, Granados H, Slazar A, Ossa JE. Antitumor and antiviral activity of Colombian medicinal plant extracts. Mem Inst Oswaldo Cruz 1999; 94(4): 531-535.
  10. [10]. Kudi AC, Myint SH. Antiviral activity of some Nigerian medicinal plant extracts. J Ethnopharmacol 1999; 68: 289-294.
  11. [11]. Philippine Medicinal Plants.Gatas-gatas. http://www. stuartxchange.org/GatasGatas.html, 2011.
  12. [12]. Kovendan K, Murugan K, Naresh Kumar A, Vincent S, Hwang JS. Bioefficacy of larvicdial and pupicidal properties of Carica papaya (Caricaceae) leaf extract and bacterial insecticide, spinosad, against Chikungunya vector, Aedes aegypti (Diptera: Culicidae) Parasitol Res. 2012;110:669–78.
  13. [13]. Ranasinghe P, Ranasinghe P, Abeysekera WP, Premakumara GA, Perera YS, Gurugama P, et al. In vitro erythrocyte membrane stabilization properties of Carica papaya L. leaf extracts. Pharmacognosy Res. 2012;4:196–202.
  14. [14]. Milianuskas G, Venskutonis PR, Vanbeek TA. Screening of radical scavenging activity of some medicinal and aromatic extracts. Food Chem. 2004;85:231–7.
  15. [15]. Singleton VL, Orthofer R, LamuelaRaventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 1999;299:152–78.
  16. [16]. Sathasivam K, Ramanathan S, Mansor SM, Haris MR, Wernsdorfer WH. Thrombocyte counts in mice after the administration of papaya leaf suspension. Wien Klin Wochenschr. 2009;121 (Suppl 3): 19–22.
  17. [17]. Patil S, Shetty S, Bhide R, Narayanan S. Evaluation of platelet augmentation activity of Carica papaya leaf aqueous extract in rats. J Pharmacogn Phytochem. 2013;1:57–60.
  18. [18]. Priyanga R, Pathmasiri R, Sirimal P, et al.,. In vitro erythrocyte membrane stabilization properties of Carica papaya L. Leaf extracts. Pharmacognosy Res. 2012 Oct-Dec; 4 (4): 196–202.
  19. [19]. Padmanaban S, Pandian L, Kalavathi MK et al.,. Flavonoid from Carica papaya inhibits NS2BNS3 protease and prevents Dengue 2 viral assembly. Bioinformation. 2013; 9(18): 889–895.
  20. [20]. Aziz J , Abu Kassim NL , Abu Kasim NH , Haque N , Rahman MT. Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells. BMC Complement Altern Med. 2015 Jul 8;15:215.
  21. [21]. Hettige S. The salutary effects of Carica papaya leaf extract in dengue fever patients a pilot study. Sri Lankan Fam Physician. 2008;29:17–9.
  22. [22]. Gowda AC, Vijay Kumar N, Kasture PN, Nagabhushan KH. A Pilot Study to Evaluate the Effectiveness of Carica Papaya Leaf Extract in Increasing the Platelet Count in Cases of Dengue with Thrombocytopenia.
  23. [23]. Ahmad N, Fazal H, Ayaz M, Abbasi BH, and Mohammad I, Fazal L. Dengue fever treatment with Carica papaya leaves extracts. Asian Pac J Trop Biomed. 2011;1:330–3.
  24. [24]. Osama S, Ayesha S. Effects of papaya leaves on thrombocyte counts in dengue a case report. J Pak Med Assoc. 2015; 10: 364-6.
  25. [25]. Ogunyemi CM, Elujoba AA, Durosinmi MA. Antisickling properties of Carica papaya Linn. J Nat Prod 2008; 1: 5666.
  26. [26]. WHO. World Health Organization. Traditional medicine. Fact Sheet. http://www.who.int/mediacentre/factsheets/fs134/en/, 2008.
  27. [27]. Meneses R, Ocazionez RE, Martinez JR, Stashenko EE. The inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro. Ann Clin Microbiol Antimicrob 2009; 8: 8.
  28. [28]. Betancur-Galvis LA, Saez J, Granados H, Slazar A, Ossa JE. Antitumor and antiviral activity of Colombian medicinal plant extracts. Mem Inst Oswaldo Cruz 1999; 94(4): 531-535.
  29. [29]. Kudi AC, Myint SH. Antiviral activity of some Nigerian medicinal plant extracts. J Ethnopharmacol 1999; 68: 289- 294.
  30. [30]. Philippine Medicinal Plants.Gatas-gatas. http://www.stuartxchange.org/GatasGatas.html, 2011.
  31. [31]. The Cure Library. Dengue fever cure using tawa–tawa aka gatas–gatas weed. http://www.curelibrary.com/blog/2007/04/, 2007.
  32. [32]. About Health. Dengue fever medicine. Available from URL: http://abouthealt-h.com/dengue-fever-medicine, 2011.
  33. [33]. Ferreira GL. Global dengue epidemiology trends. Rev Inst Med Trop Sao Paulo. 2012;54 (Suppl 18): S5-6.
  34. [34]. Gubler DJ. The economic burden of dengue. Am J Trop Med Hyg. 2012;86:743-4.
  35. [35]. Hynes NA. Dengue: A reemerging concern for travelers. Cleve Clin J Med. 2012;79:474-82.
  36. [36]. Esler D. Dengue Clinical and public health ramifications. Aust Fam Physician. 2009;38:876-9.
  37. [37]. Chaturvedi UC, Nagar R. Dengue and dengue haemorrhagic fever: Indian perspective. J Biosci. 2008;33:429-41.
  38. [38]. Paramasivan R, Dhananjeyan KJ, Leo SV, Muniaraj M, Thenmozhi V, Rajendran R, et al. Dengue fever caused by dengue virus serotype-3 (subtype-III) in a rural area of Madurai district, Tamil Nadu. Indian J Med Res 2010; 132: 339-42.
  39. [39]. Sharma S, Dash PK, Agarwal S, Shukla J, Parida MM, Rao PV. Comparative complete genome analysis of dengue virus type 3 circulating in India between 2003 and 2008. J Gen Virol 2011; 92: 1595-600.
  40. [40]. Matlani M, Chakravarti A. Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi. Braz J Infect Dis 2011; 15: 184-5.
  41. [41]. Patil JA, Cherian S, Walimbe AM, Patil BR, Sathe PS, Shah PS, et al. Evolutionary dynamics of the American African genotype of dengue type 1 virus in India (1962-2005). Infect Genet Evol 2011; 11 : 1443-8.
  42. [42]. Chaturvedi UC, Bhardwaj OP, Mathur A, Bahuguna LM, Mehrotra RML. Erythrocytic factors and viral haemagglutination. Indian J Med Res 1970; 58: 1217-25.
  43. [43]. Misra UK, Kalita J, Syam UK, Dhole TN. Neurological manifestations of dengue virus infection. J Neurol Sci 2006; 244: 117-22.