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Abstract
Calotropis procera has number of medicinal importance as it contains a number of active constituents like cardiac glycosides, terpenes, tannins flavinoids etc. it has also been found to have antispasmodic property. Therefore the present work was undertaken to evaluate the antispasmodic effect on different isolated tissues.
Methods: in-vitro models: isolated rat colon by using bioassay techniques.
In contrast to the findings of C.Procera ethnolic extract on rat colon produced antispasmodic effect on the gastrointestinal smooth muscles.
In-vitro studies of rat colon the ethnolic extract of c.procera leaves of 10mg/ml was added individually and along with acetylcholine,5-HT and carbachol produced contraction was inhibited by this crude extract.hence extract showed excellent antispasmodic activity.
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References
- 1. Chopra RN, Nayar SL and Chopra I. Glossary of Indian medicinal plants CSIR.1956:4-10
- 2. Razzak HM. Unani system of medicine in India, central council of research in Unani medicine .New Delhi 1991;45
- 3. Kirtikar, Basu BD. Indian medicinal plants lolit Mohan basu Allahabad1935;1606.
- 4. Farnsworth NR .An old source for new drugs. Pharm.techno.1995;aug:14-15
- 5. Shivakumar YM, Kumar VL. Histamine mediates the pro-inflammatory effects of latex of c.procera in rats: mediators of inflammation. 2003; 12: 299-302.
- 6. Gyton AC and Hall JE. Textbook of medical physiology.19th edn.bargalose;W B Saunderers company;1996 p.107-119.
- 7. Ghosh MN .Fundamentals of experimental pharmacology. scientific book agency 1971;39-47.
- 8. Khandelwal K R .Practical pharmacognosy.nirali Prakashan ,pune 1998;149-156.
- 9. Pillai KK. Experimental pharmacology . CBS publishers and distributors.New Delhi 1999;51-63
- 10. Singhal KC pharmacology lab manual ;CBS publishers and distributors.1997 vol 1 pg 19-25.
- 11. Mascolon ,Izzo AA ,Autore G ,Barbato F, Capasso F . Jof . pharmacol and expt ther 1994: 268;291-295
- 12. Perry WLM 1968;pharmacol expt .e &s livingstone ltd edinburg
- 13. Ganong W F. Excitible tissue ,muscle. Review of medical physiology,18th edn.,Norwalk ct .lange medical publications.1997.p.75-78.
- 14. Guptha Shakti M; plants in Indian temple art; BR publications ,New Delhi 1996;P.56
References
1. Chopra RN, Nayar SL and Chopra I. Glossary of Indian medicinal plants CSIR.1956:4-10
2. Razzak HM. Unani system of medicine in India, central council of research in Unani medicine .New Delhi 1991;45
3. Kirtikar, Basu BD. Indian medicinal plants lolit Mohan basu Allahabad1935;1606.
4. Farnsworth NR .An old source for new drugs. Pharm.techno.1995;aug:14-15
5. Shivakumar YM, Kumar VL. Histamine mediates the pro-inflammatory effects of latex of c.procera in rats: mediators of inflammation. 2003; 12: 299-302.
6. Gyton AC and Hall JE. Textbook of medical physiology.19th edn.bargalose;W B Saunderers company;1996 p.107-119.
7. Ghosh MN .Fundamentals of experimental pharmacology. scientific book agency 1971;39-47.
8. Khandelwal K R .Practical pharmacognosy.nirali Prakashan ,pune 1998;149-156.
9. Pillai KK. Experimental pharmacology . CBS publishers and distributors.New Delhi 1999;51-63
10. Singhal KC pharmacology lab manual ;CBS publishers and distributors.1997 vol 1 pg 19-25.
11. Mascolon ,Izzo AA ,Autore G ,Barbato F, Capasso F . Jof . pharmacol and expt ther 1994: 268;291-295
12. Perry WLM 1968;pharmacol expt .e &s livingstone ltd edinburg
13. Ganong W F. Excitible tissue ,muscle. Review of medical physiology,18th edn.,Norwalk ct .lange medical publications.1997.p.75-78.
14. Guptha Shakti M; plants in Indian temple art; BR publications ,New Delhi 1996;P.56