Main Article Content

Abstract

The aim of the study is to determine the outcome of women referred for Colposcopy and directed biopsy with abnormal pap smears and smears showing persistent inflammation. Cervical cancer is a significant health problem worldwide among women. Cancer cervix is the most common cancer in developing countries. It is considered as preventable cancer since there is availability of screening method and effective diagnostic and therapeutic procedures. Despite the accuracy and efficacy of cervical cytology in detecting and diagnosing cervical neoplasia, it must remain a screening technique with further evaluation based on histologic diagnosis. The objectives of the study are To study the Colposcopic features of abnormal pap smears and persistent inflammatory cellular changes on pap smear, To localize the lesion by Colposcopy and obtain a biopsy, To assess the prevalence of CIN in the study group. To correlate pap smear findings with colposcopic findings, To study the epithelial cell abnormalities by colposcopic biopsy of abnormal areas in such cases, To determine the existence of significant cervical intraepithelial lesion or invasive carcinoma in patients with persistent inflammatory pap smear. The present study is undertaken to evaluate the role of cytology and Colposcopic guided biopsy in diagnosing neoplastic cervical lesions.

Keywords

Colposcopy Cervical cancer Cervical cytology Histologic diagnosis Pap smear

Article Details

How to Cite
Dr.S.Vijaya laxmi, & Dr.Kishan Bookya. (2021). A study on colposcopic directed biopsy in early detection of premalignant and malignant lesions of cervix. International Journal of Research in Pharmacology & Pharmacotherapeutics, 5(1), 36-46. https://doi.org/10.61096/ijrpp.v5.iss1.2016.36-46

References

  1. [1]. World health organization (February 2006) fact sheet no 297; cancer, Retrieved 2007 – 12 - 01.
  2. [2]. Rejendra A Kalkar, Yogesh Kulkarini. Screening for cervical cancer: an overview. Obstet Gynecol India vol. 56 no. 2: March /April 2006.
  3. [3]. Mohammed Shaoaib Khan, Fohadiya Yasin Raja at el. Pap smear Screening for Precancerous conditions of the cervical cancers. Pak J. Med. Res.; vol. 44 no. 3, 2005:111-3.
  4. [4]. Globocan 2002 data base table by cancer, Retrieved 2008 -10 – 26.
  5. [5]. Kent A, HPV vaccination and testing, Reviews in Obstetrics and gynaecology, (2010), 3; 33 - 34.
  6. [6]. DiBonito L, Falconieri G, Tomaic G, Colautti I, Bonifacio D, Dudine S. Cervical Cytopathology: An evaluation of its accuracy based on Cytohistologic comparison. Cancer 1993; 72: 300-6.
  7. [7]. Wilkinson EJ, Paponicolou smear and screening for cervical neoplasia. Obstet Gynecol 1990; 35: 817-25.
  8. [8]. Gay JD, Donaldson LD, Goellner JR. False negative results in cervical cytological studies. Acta Cytol 1985, 29:1043-6.
  9. [9]. Moss F, Blaser MJ. Mechanism of Disease: Inflammation and origin of cancer/. Nat Clin Pract Oncol 2005; 2: 907.
  10. [10]. Seckin NC, Turhan NO, Ozmen S, Erssan F, Avoar F, Ustun H. Routine colposcopic evaluation of patients with persistent inflammatory cellular changes on pap smear. Int Gynecol Obstet 1997; 59: 25-9.
  11. [11]. McLachlan N, Patwardhan JR, Ayer B, Pacey NF. Management of suboptimal cytological smears. Acta Cytol 1994; 38: 531-6.
  12. [12]. Parashari A, Singh V, Gupta MM, Satyanarayana L, Chattopadhya D, Sodhani P, et al. Significance of inflammatory cervical smears. APMIS 1995; 103: 273-8.
  13. [13]. ACOG Practice Bulletin. Clinical management guidelines for Obstetrician and Gynecologist Cervical Cytology screening Obstet Gynecol 2003; 102:417-27.
  14. [14]. Walker EM, Dodgson J, Duncan ID. Does mild atypia on a cervical smear warrant further investigation? Lancer 1986; 2: 772-3.
  15. [15]. Giles JA, Hudson EA, Crow J, William D, Walker P. Colposcopic assessment of the accuracy of the cervical cytology screening. BMJ 1988; 296:1099-102.
  16. [16]. Soutter WP, Wisdom S, Brough AK, Monaghan JM. Should patients with mild atypia in cervical smear be referred for colposscopy? Br J Obstet Gynecol 1986; 93:70-4.
  17. [17]. Duncan ID. Guideline for clinical practice and program management. Oxford: National Coordinating Network, NHS cervical screening programme, 1993.
  18. [18]. WHO .Management of sexually transmitted diseases at district and PHC level 1999; Regional publication SERO; p.25.
  19. [19]. (Kurman RJ, Malkasian GD Jr. Sedlis A, Solomon D. From Papanicolaou to Betheda: The rationale for a new cervical cytologic classification. Obstet Gynecol 1991; 77: 779-82.)
  20. [20]. Guldeniz Aksan-Desteli, Turkan Gursu , Cem Murat Baykal, Is the Loop Electrosurgical Excision Procedure Necessary for Minor Cervical Cytological Abnormalities?,Asian Pacific Journal of Cancer Prevention,2014,15,305-308.
  21. [21]. Marchand L, Van Dinter M, Mundt M, Dingel W, Klein G Current cervical cancer screening practices of Dane county, Wsconsin Primary care clinicians. WMJ 2003; 102:3540.