Article Sidebar

Submitted
May 16, 2021
Published
May 16, 2021
Download
PDF
Statistic
Read Counter : 160 Download : 46

Main Article Content

Abstract

The ethanolic extract of Dactyloctenium aegyptium was investigated for its anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight. p. o. A significant (P<0.01, P<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer. This present study indicates that Dactyloctenium aegyptium  extract has potential anti ulcer activity in the three models tested.

Keywords

Dactyloctenium aegyptium Aspirin Gastric ulcer in rats Anti Ulcer activity

Article Details

How to Cite
Veeresh Kumar.P, S. Shobharani, M.Ravi Kumar, & T.Mangilal. (2021). Evaluation of anti-ulcer activity of ethanolic extract of Dactyloctenium aegyptium. International Journal of Research in Pharmacology & Pharmacotherapeutics, 5(1), 19-23. https://doi.org/10.61096/ijrpp.v5.iss1.2016.19-23
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. [1]. Robert A. Current history of cytoprotection. Gastroenterol 1981; 21:89-96.
  2. [2]. Gutteridge MC. Lipid peroxidation and antioxidant promoters of tissue damage. Clin Chem 1995;41:1819-29
  3. [3]. http://natureconservation.in/dactyloctenium-aegyptium-crowfoot-grass-complete-detail/.
  4. [4]. Pintusorn Hansakul1, Chatri Ngamkitidechakul2, Kornkanok Ingkaninan3, Seewaboon Sireeratawongand Watcharin Panunto. Apoptotic induction activity of Dactyloctenium aegyptium (L.) P.B. and Eleusine indica (L.) Gaerth. extracts on human lung and cervical cancer cell lines, Songklanakarin J. Sci. Technol. 31 (3), 273-279, May - Jun. 2009.
  5. [5]. Dr. Senthil P.D. HPTLC Qualitative Analysis of Pharmaceutical formations, 1972,1-71
  6. [6]. Kokate C.K. Purohit A.P., Gokhale S.B., Text book of Pharmacognosy, Nirali Prakashan, Pune VIth edition, 1997, 123-124
  7. [7]. Chandel R.S. & Rastogi R.P., Phytochemistry,19, 1980, 1889-1902.
  8. [8]. Dona, Alexander Johnson, Plant micro techniques, Ist edition, 192.
  9. [9]. Szelenyi I, Thiemer K. Distension ulcer as a model for testing of drugs for ulcerogenic side effects. Arch Toxicol 1978;41:99-105.
  10. [10]. Aguwa CN, Mittal GC. Study of antiulcer activity of an aqueous extract of Pvrenaeiith masdtii using various models of experimental gastric ulcers in rats. Eur J Pharmacol 1987;74:215-9.
  11. [11]. Verley H, Gowenlock AH, Maurice B editors. Practical clinical biochemistry. 5th ed., London. William Heineman Medical Books Limited, 1984; Vol 1, pp. 850-78.
  12. [12]. Utely HC, Bernheim F, Hochtein P. Effect of sulfhydryl reagents on lipid peroxidation in microsome. Arch Biochem Biophy 1973;188:29-32.
  13. [13]. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol. J Biol Chem 1951;193: 265-75.
  14. [14]. Szabo S, Szlenji S. Cytoprotection in gastrointestinal pharmacology. Trends Pharma Sci 1987; 8:149-54.
  15. [15]. Aly A. Prostaglandins in clinical treatment of gastroduodenal mucosal lesions: a review. Scand J Gastroenterol 1987;137:43-9.
  16. [16]. Rainsford KD. Mechanisms of gastrointestinal ulceration of non-steroidal anti- inflammatory/ analgesic drugs. Adv Inflam Res 1984;6:51-64.
  17. [17]. Vincent GP, Galvin GB, Rukowski JL, Pare WP. Body orientation, food deprivation and potentiation of restraint induced gastric lesions. Gastroent Clin Biol 1977;1: 539-43.