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Abstract
The objective of this study was to investigate the gastroprotective efficacy of rhizomes of Curcuma amada (mango ginger, Ambahaldi), Zingiberaceae in rats. The antiulcer activity of ethanolic extract was evaluated in Indomethacin, ethanol induced gastric ulcer model & stress ulcer by cold water immersion method in wistar rats. The rhizome extracts were prepared by a successive solvent extraction process with petroleum ether, chloroform, ethanol & water. Phytochemical analysis & acute oral toxicity were carried out using standard methods. The preliminary phytochemical screening of Curcuma amada revealed the presence of resins, tannins & flavanoids etc. The Ethanolic extract at a concentration of 200mg/kg & 400 mg/kg exhibit a protective effect on ulcer induced models & was compared with standard drugs Ranitidine, Misoprostol, Omeprazole. Percentage ulcer inhibition of Ethanolic extract at 400 mg/kg for Indomethacin, ethanol & stress induced ulcer model were 39.31%, 40 % & 35 % respectively. Among the doses studied ethanolic extract 400 mg/kg body weight was found to be optimum for significant reduction in ulcer. The flavanoids present in the Ethanolic extract might be responsible for the gastroprotective action probably by maintaining the antioxidant level in the gastrointestinal tract thereby reducing mucosal damage. The extract exhibit ulcer protection activity in dose dependent manner.
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References
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References
[1]. Siddaraju M. N, Dharmesh M.. Inhibition of Gastric H+,K+ATPase and Helicobacter pylori Growth by Phenolic Antioxidants of Curcuma amada. J Agric. Food Chem. 2007, 55, 7377-7386.
[2]. Sumbul Sahiba, Akhtar Mohd., Asif Mohd. Role of phenolic compound in peptic ulcer: An overview. J. Pharm & bioallied sci. 2011, 3 (3), 361.
[3]. Dashputre N. L, Naikwade N. S. Evaluation of Antiulcer activity of methanolic extract of Abutilon indicum Linn Leaves in experimental rats. Inter J Pharma Sci and Drug Res. 2011, 3(2), 97-100.
[4]. Hussain, A.; Virmani, O. P.; Popli, S. P.; Mishra, L. N.; Gupta, M. M.; Srivastava, G. N.; Abraham, Z.; Singh, A. K. Dict of Indian Medicinal Plants: CIMAP: Lucknow, India. 1992.
[5]. Mango ginger (Curcuma amada Roxb.) – A promising spicem For phytochemicals and biological activities. J. Biosci. September. 2011, 36(4), 739–748.
[6]. Kumar A, Kumar K, Deepika H, Teja.R, Kalyani.G, Inter J Innovative Pharma Res. 2011, 2(1), 88-93.
[7]. OECD guidelines 423 for testing of chemicals- Acute Oral Toxicity. 2001, 1-14.
[8]. Bhargava, K.P, Gupta M.B, Tangri K.K. Mechanism of ulcerogenic activity of Indomethacin and oxyphenbutazone. Eur J Pharmacology. 1973 22, 191- 195.
[9]. Hollander D, Taranawski A, Krause W.J, Gergely H. Gastroenterology. 1985, 88, 366–374.
[10]. Vogel G. H. Drug discovery and evaluation. Edn. 2 , Springer-verlag, Berlin Heidelberg, NewYork, 2002, pg. 869.