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May 13, 2021
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May 13, 2021
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Abstract

This study evaluated the anti-ulcer activity of the ethanolic extract of Ceiba pentandra leaves on experimentally- induced gastric ulcer in rats. Animals were pre-treated with varied doses of the extract and reference drug pantoprazole. Ulcer was induced in the animals by fasting them for 12 hours and by Cold Stress Induced Ulceration. A total of 20 rats were divided into four groups of five animals, each used for each assay.Histological studies of the gastric wall of the ulcer- induced rats were carried out. Mean ulcer index along with the percentage of ulcer inhibition by the extract and drugs were calculated for each group. Ceiba pentandra produced a significant dose dependent inhibition of gastric lesions in Cold Stress Induced ulcers evidenced by the reduced ulcer index of the treated groups. Histological examination of the gastric wall of the control rats revealed severe damage of the gastric mucosa, haemorrhages, along with oedema and leucocyte infiltration of sub-mucosal layer while the Ceiba pentandra extract-treated rats showed little damage of the gastric mucosa. These results showed that Ceiba pentandra possess ulcer protective properties against experimentally induced ulcers and validates its traditional use in the treatment of stomach pain and ulcer.

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Ceibapentandra pantoprazole gastric ulcer mucosal damage rats

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G.Madhukumar, A.Annapoorna, S.Khadeerzubair, & Bhargava Avadhanam. (2021). Anti-ulcer activity on cold stress induced ulcerative rats with column chromatographically isolated Ceiba pentandra flavonoids. International Journal of Research in Pharmacology & Pharmacotherapeutics, 3(2), 102-107. https://doi.org/10.61096/ijrpp.v3.iss2.2014.102-107
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