Article Sidebar

Submitted
May 8, 2021
Published
May 8, 2021
Download
PDF
Statistic
Read Counter : 53 Download : 35

Main Article Content

Abstract

Purpose

To study the hypoglycemic effect of ethanolic extract of Hedychium  coronarium Linn. rhizome in alloxan  induced  diabetes  in  rat  model.


Methods

The preliminary photochemical studies were carried out on the crude extract and the various chemical constituents present in the crude extract were evaluated. Acute toxicity studies as per OECD-23 guidelines to determine the safety doses of the root extract were carried out on male wistar strain of Albino rats. The various factors such as body weight, feed intake, blood glucose and serum insulin were regularly studied and evaluated.


Results

The hypoglycemic effect of ethanolic extract of Hedychium coronarium Linn. rhizome was studied on the various factors such as body weight, blood glucose levels of the alloxan induced diabetic rat model.


Conclusion

In present study administration of Hedychium coronarium Linn. rhizome extract produced a significant reduction in blood glucose, serum insulin, serum catalase and haemoglobin in alloxan induced rats. However, it seems promising that if this data will be validated in the future clinical trials, Hedychium coronarium rhizome extract may offer an alternative treatment for diabetes.

Keywords

Hedychium coronarium Linn Diabetis Albino rats Blood glucose

Article Details

How to Cite
Pranitha.K, Shalini.K, Pratibha.M, & Suneha.S. (2021). Hypoglycemic effect of ethanolic extract of hedychium coronarium linn. rhizome in alloxan induced diabetes in rat model. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(3), 239-249. https://doi.org/10.61096/ijrpp.v7.iss3.2018.239-249
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. [1]. Achut narayan kesari, Rajesh kumar gupta Hpoglycemic activity of Aegle marmelos seed extract in normal and diabetic rats, journal of ethno pharmacology. 107, 2006, 374-379.
  2. [2]. Alberti KG, Zimmet PZ, New diagnostic criteria and classification of diabetes. Diabetic medicine 15, 1998, 535-536.
  3. [3]. Allain, C.C., Poon, L.S., Chan, C.S., Richmond, W., Fu, P.C., Enzymatic determination of total serum cholesterol. Clinical Chemistry 20, 1974, 470-475.
  4. [4]. Aruna, R.V., Ramesh, B., Kartha, V.N., Effect of beta-carotene on protein glycosylation in alloxan induced diabetic rats. Indian Journal of Experimental Biology 37, 1999, 399-401.
  5. [5]. Besra SE, Sharma RM and Gomes A: Anti-inflammatory effect of petroleum ether extract of leaves of Litchi chinensis Gaertn (Sapinadaceae). J. Ethnopharmacology. 54, 1996, 1-6.
  6. [6]. Bowers, L.D., Kinetic serum creatinine assays I. The role of various factors in determining specificity. Clinical Chemistry 26, 1980, 551-554.
  7. [7]. Chakravarthy, B.K., Gupta, S., Gode, K.D., Functional beta cell regeneration in the islets of pancreas in alloxan induced diabetic rats by (-)-epicatechin. Life Sciences 31, 1982, 2693-2697.
  8. [8]. Chen, P.S., Li, J.H., Liu, T.Y., Lin, T.C., Folk medicine Terminalia catappa and its major tannin component, punicalagin, are effective against bleomycin-induced genotoxicity in Chinese hamster ovary cells. Cancer Letters 152, 2000, 115-122.
  9. [9]. Dorsch, W., Wagner, H., New antiasthmatic drugs from traditional medicine? International Archives of Allergy and Applied Immunology 94, 1991, 262-265.
  10. [10]. Duke, J.A., 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. CRC Press, Boca Raton, FL. Friedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18, 1972, 499-502.
  11. [11]. Elisabetsky E, Amador TA, Albuquerque RR, Nunes DS and Ado CC: Analgesic activity of Psychotria colorata (Willd. ex R. and S.). Muell. Arg. alkaloids. J. Ethnopharmacology. 48, 1995, 77-83.
  12. [12]. Fujimori H: Potentiation of barbital hypnosis as an evaluation method for CNS depressant. Psychopharmacology. 7, 1995, 374-377.
  13. [13]. Ghosh, S., Suryawanshi, S.A., Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian Journal of Experimental Biology. 39, 2001, 748-759.
  14. [14]. Giordano, B.P., Thrash, W., Hollenbaugh, L., Dube, W.P., Hodges, C., Swain, A., Banion, C.R., Klingensmith, G.J., Performance of seven blood glucose testing systems at high altitude. Diabetes Education 15, 1989, 444-448.
  15. [15]. Gupta BD, Dandiya PC and Gupta ML: A psychopharmacological analysis of behavior in rat. Jpn. J. Pharmacology. 21, 1971, 293-298.
  16. [16]. International Journal of Pharmaceutical Sciences and Research ISSN: 0975-8232 Available online on www.ijpsr.com 984
  17. [17]. Jain SK, Fernandes VF, Lata S and Ayub A: Indo- Amazonian ethnobotanic connections - Similar uses of some common plants. Ethnobotany 7, 1995, 29-37.Nakatani N., Kikuzaki H, Yamaji H, Yoshio K, Kitora C, Okada K and Padolina WG. Labdane diterpenes from rhizomes of Hedychium coronarium. Phytochemistry, 37, 1994, 1383-1388.
  18. [18]. Pal S, Sen T, Chaudhuri AK: Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. J. Pharm. Pharmacol. 51, 1999, 313-318
  19. [19]. Shanmugasundaram, E.R., Gopinath, K.L., Radha Shanmugasundaram, K., Rajendran, V.M.. Possible regeneration of the islets of Langerhans in streptozotocin- diabetic rats given Gymnema sylvestre leaf extracts. Journal of Ethnopharmacology 30, 1990.
  20. [20]. Shimizu, M., Horie, S., Terashima, S., Ueno, H., Hayashi, T., Arisawa, M., Suzuki, S., Yoshizaki, M., Morita, N., Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug ‘Para-parai mi’, Phyllanthus niruri. Chemical & Pharmaceutical Bulletin (Tokyo) 37, 1989, 2531-2532.
  21. [21]. Takagi K, Watanabe M and Saito H: Studies on the spontaneous movement of animals by the hole cross test: Effect of 2-dimethylaminoethane, its acylesters on the central nervous system. Jpn. J. Pharmacology. 21, 1971, 97-810.
  22. [22]. Tan, G.T., Pezzuto, J.M., Kinghorn, A.D., Hughes, S.H., Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of Natural Products 54, 1991, 143-154.
  23. [23]. Teotia, S., Singh, M., Hypoglycemic effect of Prunus amygdalusseeds in albino rabbits. Indian Journal of Experimental Biology. 35, 1997, 295-296.
  24. [24]. Toma W, Graciosa JS, Hiruma-Lima CA, Andrade FDP, Vilegas W, and Brita ARMS: Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract. J. Ethnopharmacology. 85, 2003, 19.