Main Article Content

Abstract

Introduction


Prescription pattern monitoring studies (PPMS) are useful to assess the prescribing, dispensing and distribution of medicines. They promote appropriate use of monitored drugs, reduce the misuse of these valuable resources and also help in preventing future drug resistance.


Aim of the study


To study prescription pattern of various antibiotics in a teaching hospital


Materials and Methods


An observational study was done for a period of one year from April 2017 to March 2018 in the department of Pharmacology at Mallareddy Narayana Multispecialty Hospital, Suraram, Hyderabad, Telangana. Drug related information like number of drugs prescribed, dose, route of administration, frequency, indication, therapy duration, month of admission, the total number of drugs prescribed, total number of antibiotics prescribed were studied.


Results


In the present study majority of patients, 43.3% (130/300)   were among 31-40 years, followed by 16.6% (50/300) patients among 41-50 years. Male predominance (66.6%) compared to females (33.3%) was seen. On clinical diagnosis, Respiratory tract infections were the most common in  50% (150/300) cases and  antibiotics were prescribed in high percentage (21.5%), followed by viral fever (16.6%). 195(65%) prescriptions had antibiotic monotherapy, 72 (24%) prescriptions had two antibiotic drugs, 33 (11 %) prescriptions had more than 2 antibiotic drugs. Cephalosporins were commonly prescribed in 173 (49.4%) cases.


Conclusion


Various clinical conditions across all age groups require use of antibiotics. Respiratory tract infections are the most common indications for prescribing antibiotics. Cephalosporins and quinolones are the most commonly prescribed antibiotics. Antibiotic monotherapy is commoner than usage of multiple antibiotics. Rational use of appropriate antibiotics can obviate drug resistance in future and continuous monitoring of antibiotic usage in hospitals is recommended.

Keywords

Prescription pattern Antibiotics Drugs Monitoring antibiotics

Article Details

How to Cite
Dr K.Vashishta. (2021). Observational study on prescription pattern of various antibiotics in a teaching hospital. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(2), 151-156. Retrieved from https://ijrpp.com/ijrpp/article/view/280

References

  1. [1]. Strom BL, Stephan EK. editors. Pharmacoepidemiology. 4th ed. Wiley-Blackwell: John Wiley and Sons, English; 2005.
  2. [2]. Gross F. Drug utilization therapy and practice: The present situation in the Federal Republic of Germany. Eur J Clin Pharmacol 19, 1981, 387-94.
  3. [3]. Cochrane et al. Effectiveness and efficiency – random reflections on health services. London, the Nuffield provincial hospitals trust, 1982.
  4. [4]. Stolley PD, Lasagna L. Prescribing patterns of physicians. Journal of Chronic Diseases 22, 1969, 395-405.
  5. [5]. Westerholm B. Therapeutic auditing at the national and international levels. Br J Clin Pharmacol 22, 1986, 55s-9s.
  6. [6]. Pullar T, Kumar S, Tindall H, Freely M. Time to stop counting the tablets? Clin pharmacol Ther 46, 1989, 163-8.
  7. [7]. Ahmad A, Parimalakrishnan, Mohanta GP, Patel I, Manna PK. A study on utilization pattern of higher generation antibiotics among patients visiting community pharmacies in Chidambaram, Tamilnadu at South India. Int J Pharm.
  8. [8]. Arnold SR, Allen UD, Al-zahrani M, Tan DH, Wang EE. Antibiotic prescribing by pediatricians for respiratory tract infection in children. Clin Infect Dis 29, 1999, 312-7.
  9. [9]. Mccaig LF, Hughes JM. Trends in antimicrobial drug prescribing among office-based physicians in the United States. JAMA 273, 1995, 214-9.
  10. [10]. Esposito S, Leone S. Antimicrobial treatment for intensive care unit (ICU) infections including the role of the infectious diseases specialist. Int J Antimicrob Agents 29, 2007, 494–500.
  11. [11]. Lockhart SR, Abramson MA, Beekman SE, Gallagher G, Riedel SR, Diekma DJ, et al. Antimicrobial resistance among gram-negative bacilli as causes of infections in intensive care unit patients in the United States between 1993 and 2004. J Clin Microbiol 45, 2007, 3352–9.
  12. [12]. Weber RJ, Kane SL, Oriolo VA, Saul M, Skledar SJ, Dasta JF. Impact of intensive care drug costs: a descriptive analysis, with recommendations for optimizing ICU pharmacotherapy. Crit Care Med. 31, 2003, 17–24.
  13. [13]. WHO model lists of essential medicines 19 th edn. Geneva: World Health Organization; 2015
  14. [14]. Bapna JS, Tekur U, Gitanjali B, Shashindran CH, Pradhan SC, Thulasimani M, et al. Drug utilization at primary health care level in Southern India. Eur J Clin Pharmacol 43, 1992, 413-5
  15. [15]. Williams A, Mathai AS, Phillips AS. Antibiotic prescription patterns at admission into a tertiary level intensive care unit in Northern India. J pharm Bioallied Sci 3(4), 2011, 531–536.
  16. [16]. Snehapallavi P, Tejasree B, Krishnakanth PV. Study of prescription patterns of antibiotics in tertiary care hospital. International Journal of Biomedical Research 7(6), 2016, 372-374.
  17. [17]. Ahmad A, Revanker M, Haque I, Pravina A, Ivan R, Dasari R, et al. The prescription pattern of antibiotics in the medicine department in a teaching hospital: a descriptive study IJTPR 6(3), 2014, 43-46.
  18. [18]. Drupad HS, Nagabushan H, Prakash GM. Prospective and observational study of antimicrobial drug utilization in medical intensive care unit in a tertiary care teaching hospital. International Journal of Pharmacology 6(1), 2016, 13
  19. [19]. Kapure NL, Nayak BB, Raul AR, Vijaykumar AN, Vijayprasad S, Vakade KP, et al. Study of prescribing pattern of antimicrobial agents in an IPD of a tertiary care hospital in Ahmednagar. International Journal of Medical Research and Health Sciences 3(1), 2013.