Main Article Content


Background and Aim

Epilepsy is one of the most common neurological disorders characterized by recurrent episodic paroxysmal involuntary clinical events associated with abnormal electrical activity from the neurons. Antiepileptic treatment in pediatric age group should be aimed to control seizures associated with the lowest possible occurrence of adverse effects, thus allowing the child to become an active member of the community. Present study was performed with an aim to evaluate the adverse drug reactions (ADRs) caused by the anti-epileptic drugs Among Pediatric Patients of tertiary care teaching hospital of Gujarat.

Material and Methods

The present cross-sectional study was conducted at the epilepsy clinic of Department of Paediatrics, Tertiary Care teaching hospital of Gujarat, on patients diagnosed to have epilepsy July 2014 to October 2014. Hundred Paediatric patients of either gender diagnosed to had epilepsy and taking treatment from pediatric epilepsy clinic OPD, Tertiary Care teaching hospital of Gujarat. Patient’s detailed medical history, drug reports, demographic data, type of seizures, the anti-epileptic drugs prescribed and the adverse drug reactions (ADRs) reported by the patients were recorded in a pre-structured data entry form.


Out of 100. GTCS was found to be the most common (55%) form of epilepsy among pediatric patients and Carbamazepine was the most commonly prescribed (41%) AED followed by sodium valproate (38%).24 patients suffered from ADRs of antiepileptic drugs. Out of which 7 patients suffered from drowsiness and suspected drug for this ADR were clobazam, levetiracetam and carbamazepine. Six patients suffered from irritability and suspected drugs for this ADR were clobazam, carbamazepine.


Total 24 patients suffered from ADRs of antiepileptic drugs. Drowsiness was most commonly observed ADR and suspected drugs for this ADR were clobazam, levetiracetam and carbamazepine.


Adverse drug reactions Carbamazepine Drowsiness Epilepsy

Article Details

How to Cite
Hirenkumar H Dave, & Niyati A Trivedi. (2021). Adverse drug reactions of antiepileptic agents among pediatric patients at tertiary care teaching hospital of Gujarat- a cross-sectional study. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(2), 138-144. Retrieved from


  1. [1]. Ghai essential paediatrics fifth edition, O.P.Ghai, PiyushGupta,V.K.Paul, 408.
  2. [2]. Goodman & Gilman’s the pharmacological basics of therapeutics 12.
  3. [3]. WHO. World Health Organization: Epilepsy: Epidemiology, aetiology and prognosis. WHO Factsheet 2001b.
  4. [4]. Dwivedi C. Antiepileptic Drugs. Am.J.pharm.educ,. 65, 2001, 197-201.
  5. [5]. Stein MA, Kanner AM. Management of newly diagnosed epilepsy. A practical guide to monotherapy. Drugs 69(2), 2009, 199-222
  6. [6]. Pahl K, de Boer HM. Atlas: epilepsy care in the world. Geneva: WHO; 2005. Epilepsy and rights; 72–3.
  7. [7]. Dwivedi C. Antiepileptic Drugs. 65, 2001, 197-201.
  8. [8]. O.P.Ghai, Piyush gupta, V.K.Paul , Ghai essential paediatrics 5, 408.
  9. [9]. Pahl K, De Boer HM. Atlas: epilepsy care in the world. Geneva: WHO; Epilepsy and rights; 2005, 72–3
  10. [10]. Hasan SS, Bahari MB, Babar ZU, Ganesan V. Antiepileptic drug utilisation and seizure outcome among paediatric patients in a Malaysian public hospital. Singapore Med J 51(1), 2010, 21-7.
  11. [11]. Kousalya K, SwathiCherukuri DP, Padmasani LN, ArunPrasath TS. Drug utilization pattern of antiepileptics and their adverse effects in pediatrics. world journal of pharmaceutical research 2014, 3(9), 2014, 504 – 513.
  12. [12]. Rusva A. Mistry, Krunal C. Solanki, Hiren K. Prajapati, Tejas M. Doshi, Hiren R. Trivedi. Drug utilization pattern of antiseizure drugs and their adverse effects in the pediatric population, in a tertiary care hospital attached to a medical college Jamnagar. pharmacology International Journal of Basic & Clinical Pharmacology 3(2), 2014, 336 – 442.
  13. [13]. World Health Organization (WHO). Primary prevention of mental, neurological, psychological disorder. Geneva: WHO Press, World Health Organization (Online); Available from: 1998
  14. [14]. Krumholz A, Wiebe S, Gronseth G, Shinar S, Levisohn P, Ting T, et al. Evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the quality standards subcommittee of the American academy of neurology and the American epilepsy society. Neurology 69, 2007, 1996-2007.
  15. [15]. Sandeep A , Surya Chandra D, Bhanu Chand T, Saravaran S, Saravana Kumar RT. Study of Drug utilization , Cost effectiveness and outcome of antiepileptics used in pediatric ward of tertiary care hospital in tamilnadu, India.Iinternational journal for pharmaceutical research scholars 2(4), 2013, 409 – 502.
  16. [16]. Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and management of epilepsy in children and young people- A national clinical guideline. (Online) . Available from: 2005, 2015