Main Article Content

Abstract

Background


Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. This disease constitutes a major health concern affecting about 2.8% of the global population. Currently available synthetic antidiabetic agents produce serious side effects. This leads to a demand for herbal products with antidiabetic activity and fewer side effects. Hence shilajit a herbo-mineral substance with a wide spectrum of biological activity is being evaluated for its anti diabetic activity.


Aim of the study


To evaluate thehypoglycemic activity of shilajit in alloxan induced diabetic rat model and to compare hypoglycaemic activity of shilajit with standard drug, glibenclamide.


Materials and Methods


Alloxan induced (150mg/kg.i.p) diabetic rats were divided into six groups of six animals each weighing 150-200 gms. Group I - Diabetic control: Normal saline. Group II - Standard: Normal saline + Glibenclamide (5mg/kg). Group III – Normal saline + Shilajit dose D1 50mg/kg, Group IV- Normal saline + Shilajit dose D2 100mg/kg, Group V- Normal saline + Shilajit dose D3 150mg/kg, Group VI- Normal saline + Shilajit dose D2 100mg/kg+ Glibenclamide (5mg/kg). All drugs are given once daily orally for 21 days and fasting blood glucose was estimated from blood taken from rat tail vein using glucometer on 0, 7th, 14th, 21st days.


Results


Shilajit by itself has significant hypoglycemic effect. Its hypoglycemic effect is comparable to glibenclamide when used in doses 50mg/kg, 100mg/kg, but when used in dose of 150mg/dl it showed lesser effect. Shilajit when combined with glibenclamide showed potentiated hypoglycemic effect.


Conclusions


The result in this study suggests that shilajit can be used as monotherapy in doses 50mg/kg, 100mg/kg and complementary medicine with glibenclamide for diabetes mellitus.

Keywords

Diabetes mellitus Albino rats Alloxan monohydrate Fasting blood sugar Glibenclamide Shilajit

Article Details

How to Cite
Ravi H Kudthni, Prasad S R, & Basavanna P L. (2021). Evaluation of hypoglycaemic activity of shilajit in alloxan induced diabetic rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 6(3), 374-380. https://doi.org/10.61096/ijrpp.v6.iss3.2017.374-380

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