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May 3, 2021
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May 3, 2021
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Abstract

Background


Changes in the lipid profile has been reported to be associated with oral cancer and also in cases of oral premalignant lesions and conditions. This study was done to assess the relationship between plasma lipid profile and oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL). OL is a potentially malignant lesion which could transform into malignancy hence this study evaluates the correlation of cholesterol levels and leukoplakia and also the tobacco abusers.


Aims


to assess the serum lipid levels in OL and OSCC and to look for any relation between incidence of OL and OSCC and lipid profile levels


Settings and design


This study included a total of 126 subjects of which 30 had OL and 30 had OSCC  and 66 were age and sex matched controls.


Materials and methods


Analysis of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL), triglycerides (TGL) levels were done using the standard reagents from erba diagnostics, Daman.


Statistical analysis used


SPSS package 14th version and ANOVA was used for multiple group comparison followed by students T test for pair wise comparison.


Results


Plasma levels of HDL, VLDL, TGL and ratio of HDL and LDL was significantly reduced in patients with OSCC and OL. Plasma TC and LDL was significantly reduced in patients with speckled leukoplakia when compared with the rest of the types.


Conclusions


There was a inverse relationship between lipid profile and OSCC and OL. 

Keywords

Lipid profile Oral leukoplakia Oral squamous cell carcinoma

Article Details

How to Cite
Dr.Shantala R Naik, Dr Ashok L, & Dr Prashant Gupta. (2021). Plasma lipid profile patterns in oral leukoplakia and oral squamous cell carcinoma. International Journal of Research in Pharmacology & Pharmacotherapeutics, 6(3), 364-373. https://doi.org/10.61096/ijrpp.v6.iss3.2017.364-373
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