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Abstract
Inflammation and pain are the most common health problems treated with traditional remedies which mainly comprise medicinal plants. A number of natural products are used in the traditional medical systems in many countries. An alternative medicine for the treatment of various diseases is getting more popular. Many medicinal plants provide relief of symptoms comparable to that of obtained from allopathic medicines. Therefore agents of natural origin with very little side effects are required as substitute chemicals therapeutics. The Ayurvedic preparations include Rheumartho and Rheumatil (150µg/ml, 300µg/ml, and 450µg/ml)was investigated for anti-inflammatory effects in Invitro Method. Human red blood cells membrane stabilization method and inhibition of albumin denaturation was adopted for the in-vitro anti-inflammatory activity. The ayurvedic drugs were effective in inhibiting the heat induced haemolysis at different concentrations. The results showed that Rheumatil and Rheumartho at concentration 150 µg/ml, 300µg/ml protect significantly (P<0.01) the Erythrocyte membrane against lysis induced by heat.It was concluded thatAyurvedic preparations (Rheumartho and Rheumatil)possess anti-inflammatory with lesser side effects and more beneficial effects.
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References
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- [5]. Chou, C.T.; The anti inflammatory effects of Tripterygium wilfordii Hook F on adjuvant induced paw edema in rats and inflammatory mediators release. Phytother Res. 11, 1997, 152-54.
- [6]. Ganapathy, S. Dash, G.K.; Diuretic and laxative activity of CocculushirsutusFitotherapia73, 2002, 1, 28-31.
- [7]. Hosseinzadeh, H. Ramezani, M. Fadishei, M. Mahmoudi, M.; Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeriamajdaeextracts in mice and ratsPhytomedicine, 9, 2002, 135-141.
- [8]. Jeane Silva, Worku Abebeb, S.M. Sousa, V.G. Duarte, M.I.L. Machadoc, F.J.A. Matos; Analgesic and anti inflammatory effects of essential oils of Eucalyptus. J. Ethnopharmacol, 89, 2003, 277–283.
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- [10]. Kirtikar k r & basu b d, Indian medicinal plants. (bishen sing mahendre pal sing, dehradun, India) 2, 1999, 655.
- [11]. Sadique J, Chandra T, Thenmozhi V and Elango V. The anti-inflammatory activity Enicostemmalittorale and mullogo cerviana. Biochem Med Metab Biol 37, 1987, 167-176.
- [12]. Jyoti M, Vasu V T, Ravikumar A and SaritaG.Glucose lowering effect of aqueous extract if Enicostemma littorale Blume in diabetes a possiblemechanism of action. Journal of Ethnopharmacol 81, 2000, 199-204.
References
[1]. Albert, D. Zundorf, I. Dingermann, T. Muller, W.E. Steinhilber, D. Werz, O; Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5- lipoxygenase. Biochem. Pharmacol, 64, 2002, 1767–1775.
[2]. Bartolini, A. Galli, A. Ghelardini, C. Giotti, A. Malcangio, M. Malmberg-Aiello, M. P. Zucchi, P. L. British J. Pharmacol,711, 1987, 92.
[3]. Berkenkopf, J.W. Weichmann, B.M.; Production of prostacyclin in mice following intraperitoneal injection of acetic acid, phenyl benzoquinone and zymosan, its role in the writhing response. Prostag. Leukotr. Ess. 36, 1988, 693–709, 1210–1214.
[4]. Chakraborty, A. Devi, R.K.B. Rita, S. Sharatchandra, K. Singh, T.I.; Preliminary studies on anti-inflammatory and analgesic activity of Spilanthesacmella in experimental animal models. Indian J. Pharmacol. 36, 2004, 148–150.
[5]. Chou, C.T.; The anti inflammatory effects of Tripterygium wilfordii Hook F on adjuvant induced paw edema in rats and inflammatory mediators release. Phytother Res. 11, 1997, 152-54.
[6]. Ganapathy, S. Dash, G.K.; Diuretic and laxative activity of CocculushirsutusFitotherapia73, 2002, 1, 28-31.
[7]. Hosseinzadeh, H. Ramezani, M. Fadishei, M. Mahmoudi, M.; Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeriamajdaeextracts in mice and ratsPhytomedicine, 9, 2002, 135-141.
[8]. Jeane Silva, Worku Abebeb, S.M. Sousa, V.G. Duarte, M.I.L. Machadoc, F.J.A. Matos; Analgesic and anti inflammatory effects of essential oils of Eucalyptus. J. Ethnopharmacol, 89, 2003, 277–283.
[9]. Gerard J Tortora, Sandra Reynolds, eds. Principles of Anatomy and Physiology. Harper Collins College Publishers, 7, 1993, 695.
[10]. Kirtikar k r & basu b d, Indian medicinal plants. (bishen sing mahendre pal sing, dehradun, India) 2, 1999, 655.
[11]. Sadique J, Chandra T, Thenmozhi V and Elango V. The anti-inflammatory activity Enicostemmalittorale and mullogo cerviana. Biochem Med Metab Biol 37, 1987, 167-176.
[12]. Jyoti M, Vasu V T, Ravikumar A and SaritaG.Glucose lowering effect of aqueous extract if Enicostemma littorale Blume in diabetes a possiblemechanism of action. Journal of Ethnopharmacol 81, 2000, 199-204.