Main Article Content

Abstract

Background


Wounds are the common skin disorders. It can occur by various methods. Agents having wound healing activity have wide therapeutic uses. The present study was planned to evaluate wound healing activity of hydroalcoholic extract of Vetiveria ziznoides roots in Wistar Albino rats


Materials and Methods


This study was done in the department of Pharmacology, SMIMS. Total 24 rats were divided in to four groups each of 6 rats. G-I: Control, G-II: HAEV.Zroot (75 mg/kg), G-III: HAEV.Zroot (150 mg/kg) and G-IV: HAEV.Zroot (300 mg/kg). 6 cm length of incision was made at para vertebral palace. Rats were given test drugs one week before incision made and one week after incision. Control group treated with distilled water. On 15th day tensile strength was measured.


Results


Significant difference was observed in the tensile strength with high dose of test drug compared to low dose and control group.


Conclusion


In conclusion, pre-administration of V.Z root increased wound healing compared to control group. Further studies required to find the mechanism of action.

Keywords

Anti-oxidant Hydroalcoholic extract Healing Incision Para vertebral Tensile strength

Article Details

How to Cite
Chakradhar T, & Sarath Babu K. (2021). Evaluation of wound healing activity of hydroalcoholic extract of vetiveria ziznoides roots in wistar albino rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(1), 97-99. Retrieved from https://ijrpp.com/ijrpp/article/view/239

References

  1. [1]. Nayak BS, Anderson M, Pereira LMP. Evaluation of wound-healing potential of Catharanthus roseus leaf extract in rats. Fitoterapia. 78, 2007, 540–4.
  2. [2]. Chomchalow N. Production of Medicinal and Aromatic Plants in Southeast Asia. AU J T 4, 2000, 84-94
  3. [3]. Singh KK, Maheshwari JK. Traditional phytotherapy amongst the tribals of Varanasri district, U.P. J Econ Tax Bot 19834, 829-838.
  4. [4]. Balasankar D, Vanilarasu K, Selva PP, Rajeswari MU, Debjit B. Traditional and medicinal uses of vetiver. JMPS 1(3), 2013, 191-200.
  5. [5]. Srivatavanidhi, Jain JK, Dubey MP, Ragubir R. Role of free radicals scavenger in wound healing, Abstract 31st Annual of Indian Pharmacological Society 18-21st 1998, 90.
  6. [6]. Bagheri M, Jahromi BM, Mirkhani H, Soihjou Z, Noorafshan A, Amirghofran Z et al. Azelnidipine, a new calcium channel blockers, promotes skin wound healing in diabetic rats. J Surg Res 169(1), 2011, 101-7.
  7. [7]. Bagheri M, Jahromi BM, Mirkhani H, Soihjou Z, Noorafshan A, Amirghofran Z et al. Azelnidipine, a new calcium channel blockers, promotes skin wound healing in diabetic rats. J Surg Res 169(1), 2011, 101-7.
  8. [8]. Rajesh SP, Pradeep KC, Harish R, Pradeep KS, Fedelic AT, Ankit J. Wound healing activity of Sida cordifolia Linn. In rats. IJP 45(5), 2013, 474-78.
  9. [9]. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol. 59(3), 1998, 179-86.
  10. [10]. Gal P, Toporcer T, Vidinsky B, Mokry M, Novotny M, Kilik R, Smetana K, Gal T et al. Early changes in the tensile strength and morphology of primary sutured skin wounds in rats. Folia Biol 52(4), 2006, 109-15.
  11. [11]. Costan WB, Stephen CW, John NH, Edwin JP. Healing of incisional wounds in rats the relationship of tensile strength and morphology to the normal skin wrinkle lines. Ann Surg 159(2), 1964, 260-70.
  12. [12]. Rozaini MZ, Zuki ABZ, Noordin M, Norimah Y, Nazrul AH. The effect of different types of honey on tensile strength evaluation of burn wound tissue healing. IJARVM 2(4), 2004, 290-6.