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The use of pharmacokinetic-pharmacodynamic (PK/PD) properties of certain antibiotics, if used judiciously, could be an effective way to improve drug concentration in body and hence, clinical outcomes. The aim and objective of this study was to observe the prescription pattern of selected antibiotics in indoor patients who were admitted in ICU and ward. In this study it was observed whether antibiotics were prescribed following PK/PD properties. This study focused on drug dosing pattern along with adjustment with creatinine clearance in renal impairment and duration of antibiotic infusion during individual dose of the antibiotics. This observational single center study was conducted for 256 patients. Among them, 16 patients were excluded and 240 patients were finally analyzed as they met the inclusion criteria. In the demographic parameter described it was found that the mean age was in elderly population. It was a male predominant cohort and mostly patients were included from intensive care area. It was observed that culture growth occurred in 53% cases and rest 47% showed negative culture. In majority of cases appropriate antibiotics were given. About 94.74 % were appropriate antimicrobials. The sources of sepsis were lung, and renal in majority however, other sources like GIT, skin and soft tissue, or hepato- bilary, were also there. The major sources of infections in this study were lung and renal (n=70), followed by unknown source (n= 42). The correlation of drug dose adjustment with renal clearance was also investigated in this study. Adjustment of drug following creatinine clearance was mostly found in intensive care area as compared to ward. From this study it could be commented that dose adjustment following creatinine clearance is not that prevalent in ward and should be emphasized to improve clinical outcome and to avoid drug toxicity.


Pharmacokinetic Parameter Pharmacodynamic Parameter Creatinine Clearance Meropenem Vancomycin Colistin

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Poulami Chatterjee, Mahuya Bhattacharya, Pintu Kr De, & Tapan Kr. Chatterjee. (2021). Potential observational study of exploitation of pharmacokinetic principles of antibiotics used for indoor patients. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(1), 49-60. Retrieved from


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