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The study was done after obtaining approval from the institutional animal ethical committee of JJM Medical College, Davangere and CPCSEA. A total of 60 Swiss albino mice inbred in the Central Animal House of J.J.M.M.C of either sex and of weight between 20-40g and aged 3-4 months were taken for the study. They were divided into 10 groups of 6 animals each. The antidepressant activity of tramadol and tapentadol was evaluated in mice using forced swim test model and tail suspension test model.

In both the experimental models, Group i received normal saline- 10ml/kg(control group), group ii,iii,iv,v were given tramadol 20mg/kg, tramadol 40mg/kg, tapentadol 20mg/kg and tapentadol 40mg/kg respectively, once a day for 7 days. The drugs were given intraperitoneally.

On day 7, the drugs were given 1 hour before conducting the experiment. The duration of immobility was noted and compared amongst the 5 groups in both the models. The observations were analyzed using ANOVA (one way) and post hoc Tukey’s test. The test drugs tramadol and tapentadol showed significant reduction in duration of immobility in both the models. In FST model, tapentadol showed significant reduction in duration of immobility at the dose of 20mg/kg (34.67sec) when compared to 40mg/kg (67.5sec); (P <0.003) and was comparable to tramadol at a dose of 20mg/kg (36sec). In TST model, tapentadol at 20mg/kg has shown a greater reduction in duration of immobility (54.8sec) as compared to tramadol at 20mg/kg (106.17sec). Tapentadol showed a greater antidepressant activity compared to tramadol in TST model (P<0.001) and showed similar activity but was statistically insignificant.

Both tramadol and tapentadol have shown significant antidepressant activity in comparison with control group in both the test models. Tapentadol has shown better antidepressant activity than tramadol in TST model. Hence further animal studies with different model for depression and clinical studies should be conducted to confirm these findings and in choosing the better drug for treatment of chronic painful conditions like cancer which is often associated with depression.


Antidepressant Tapentadol Tramadol

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Dr. Narendranath S, Dr. Shruthi K.S, & Dr. Pradeep B E. (2021). Comparative evaluation of antidepressant activity of tramadol and tapentadol in swiss albino mice. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(1), 40-48. Retrieved from


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