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Abstract
The objective of the present study is to evaluate the sexual performance (aphrodisiac activity) of ethanolic leaf extract of Ipomoea sepiaria on male Wistar albino rats and the effects was compared with reference control Sildenafil citrate. Male Wistar albino rats were divided in to 4 groups of 6 animals each. Ethanolic leaf extract of Ipomoea sepiaria (200 & 400mg/kg ) were administered orally and its sexual performance was compared to the normal and reference control animals (Sildenafil citrate 4.5mg/kg body weight). The effect of Ipomoea sepiaria on sexual performance in male rats were observed by mount frequency, mount latency, intromission frequency, intromission latency, genital grooming and ano – genital sniffing. The data’s were analyzed using ANOVA followed by dunnetts’t’ test. Ipomoea sepiaria showed dose dependent increase in mounting frequency, intromission frequency, ano-genital sniffing and genital grooming and decrease in mount latency and intromission frequency as compared to control. The ethanolic leaf extract of Ipomoea sepiaria showed comparable aphrodisiac effect with the reference control Sildenafil citrate. From the result it was concluded that, ethanolic leaf extract of Ipomoea sepiaria exhibits dose dependent increase in sexual desire in male Wistar albino rats.
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References
- [1]. Zamble A, Sahpaz S, Brunet C, Bailleul F. Effects of Microdesmis keayana roots on sexual behavior of male rats. Phytomed, 15(8), 2008, 625-629.
- [2]. Ontorsi F, Salonia A. A Dehaf Cestari, Guazzoni, Pharmacological management of erectile dysfunction. Br J Urol, 8, 2003, 211‐216.
- [3]. Habsigh B, Anastasiadics AG. Erectile Dysfunction. Ann Rev Med, 45, 2003, 153‐168.
- [4]. Yakubu MT, Bilbis LS, Lawal M, Akanji MA. Effect of repeated administration of sildenafil citrate on selected enzyme activities of liver and kidney of male albino rats. Nig J Pure Appl Sci, 18, 2003, 1395‐4000.
- [5]. Kulkarni SK, Reddy DS. Pharmacotherapy of Male Erectile Dysfunction with Sildenafil. Ind JPharmacol, 30, 1998, 367-378.
- [6]. Das S N, Ray B, Mahapatra S K and Pothal R K. Microbiological potentiality of Ipomoea sepiaria Roxb. Intl J Res Biomed Sci, 2(2), 2011, 500-502.
- [7]. Majumder S, Ashok B K, Nishteswar K. Phytochemical and antifungal studies on root of Ipomoea sepiaria Koenig Ex. Roxb. GJRMI, 1(8), 372-380, 2012.
- [8]. Subramoniam A, Madhavachandran V, Rajasejharan S, Pushpangadan P. Aphrodisiac property of Trichopus zeylanicus extract in male mice. J Ethnopharmacol, 57, 1997, 21-27.
References
[1]. Zamble A, Sahpaz S, Brunet C, Bailleul F. Effects of Microdesmis keayana roots on sexual behavior of male rats. Phytomed, 15(8), 2008, 625-629.
[2]. Ontorsi F, Salonia A. A Dehaf Cestari, Guazzoni, Pharmacological management of erectile dysfunction. Br J Urol, 8, 2003, 211‐216.
[3]. Habsigh B, Anastasiadics AG. Erectile Dysfunction. Ann Rev Med, 45, 2003, 153‐168.
[4]. Yakubu MT, Bilbis LS, Lawal M, Akanji MA. Effect of repeated administration of sildenafil citrate on selected enzyme activities of liver and kidney of male albino rats. Nig J Pure Appl Sci, 18, 2003, 1395‐4000.
[5]. Kulkarni SK, Reddy DS. Pharmacotherapy of Male Erectile Dysfunction with Sildenafil. Ind JPharmacol, 30, 1998, 367-378.
[6]. Das S N, Ray B, Mahapatra S K and Pothal R K. Microbiological potentiality of Ipomoea sepiaria Roxb. Intl J Res Biomed Sci, 2(2), 2011, 500-502.
[7]. Majumder S, Ashok B K, Nishteswar K. Phytochemical and antifungal studies on root of Ipomoea sepiaria Koenig Ex. Roxb. GJRMI, 1(8), 372-380, 2012.
[8]. Subramoniam A, Madhavachandran V, Rajasejharan S, Pushpangadan P. Aphrodisiac property of Trichopus zeylanicus extract in male mice. J Ethnopharmacol, 57, 1997, 21-27.