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Abstract

The objective of the study is to find out the protective effect of Ipomoea sepiaria on Sodium Arsenite induced toxicity in Wistar rats. The liver and kidney toxicity was induced by Sodium Arsenite (8 mg/kg, p.o.) for 60 days. Ethanolic leaf extract of Ipomoea sepiaria (200 & 400mg/kg) was administered orally for 60 days. At the end of the entire treatment, under Pentobarbitone sodium (60mg/kg, i.p), anaesthesia, the blood was collected by retro orbital puncture and serum was separated for biochemical estimations especially for Liver (SGOT, SGPT, ALP, Bilirubin and Protein) and Kidney (Serum urea and Creatinine). The Data’s were analyzed by using ANOVA. The result shows that higher dose of Ipomoea sepiaria reversed the biochemical parameter of both Liver functional test and the Kidney functional test in a significant manner as compared to Sodium Arsenite control. From the result it was concluded that, ethanolic leaf extract shows protective effect against Sodium Arsenite induced toxicity in rats in a dose dependent manner.

Keywords

Sodium Arsenite Ipomoea sepiaria Toxicity Heavy Metal

Article Details

How to Cite
Vedavijaya Thangappan, Premlal Kulandai Raj, & Sengottuvelu Singaravel. (2021). Protective effect of ethanolic leaf extract of ipomoea sepiaria against sodium arsenite induced toxicity in rats . International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(1), 20-24. Retrieved from https://ijrpp.com/ijrpp/article/view/229

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