Main Article Content
Abstract
The objective of the study is to find out the protective effect of Ipomoea sepiaria on Sodium Arsenite induced toxicity in Wistar rats. The liver and kidney toxicity was induced by Sodium Arsenite (8 mg/kg, p.o.) for 60 days. Ethanolic leaf extract of Ipomoea sepiaria (200 & 400mg/kg) was administered orally for 60 days. At the end of the entire treatment, under Pentobarbitone sodium (60mg/kg, i.p), anaesthesia, the blood was collected by retro orbital puncture and serum was separated for biochemical estimations especially for Liver (SGOT, SGPT, ALP, Bilirubin and Protein) and Kidney (Serum urea and Creatinine). The Data’s were analyzed by using ANOVA. The result shows that higher dose of Ipomoea sepiaria reversed the biochemical parameter of both Liver functional test and the Kidney functional test in a significant manner as compared to Sodium Arsenite control. From the result it was concluded that, ethanolic leaf extract shows protective effect against Sodium Arsenite induced toxicity in rats in a dose dependent manner.
Keywords
Article Details
References
- [1]. Schneider AR, Morvan X, Saby NPA, Cances Be, Ponthieu M, Gommeaux M, Marin B. Multivariate spatial analyses of the distribution and origin of trace and major elements in soils surrounding a secondary lead smelter. Environ Sci Pollut Res. 23, 2016, 1–11.
- [2]. Lynn S, Shiung JN, Gurr JR, Jan KY. Arsenic stimulates poly (ADPribosylation) by generation of nitric oxide. Free Rad Biol Med. 24, 1998, 442–449.
- [3]. AiyerK N, Namboodiri AN, Kolammal M. Pharmacognosy of Ayurvedic Drugs. Series-I. Number-3. The Central Research Institute: University of Travancore; 1957, 57-63.
- [4]. Kirtikar KR, Basu BD. Indian medicinal plant. 3,1960, 1702-1712
- [5]. Prajapati ND, Purohit SS, Sharma AK, Kumar T. A hand book of Indian Medicinal Plants, A complete Source Book. India, Agrobios, 2003, 291-292.
- [6]. Venkataswamy R, Mubarack HM. Ethnobotanical Study of Medicinal plants used by Malasar tribals in Coimbatore District of Tamil Nadu (South India). Asian J Exp Biol Sci, 1 (2), 2010, 387 – 392.
- [7]. Jain SK. Dictionary of Indian Folk Medicine and Ethnobotany. Deep Publication, 1991, 108.
- [8]. Nishteswar K. Herbs in Vasavarajeeyam. Delhi, Chaukhamba Sanskrit Pratishthan, 2003, 86.
- [9]. Arun Kumar, Ranjit Kumar, Mohammad Samiur Rahman, Mohammad Asif Iqubal, Gautam Anand, Pintoo Kumar Niraj and Mohammad Ali. Antidote Effects of Plants of Himalayan Sub-Origin Against Arsenic Induced Toxicity. Biol Chem Res, 2015, 99-109.
- [10]. Retimen S, Frankel SA. Colorimetric method for determination of Serum Glutamic Oxaloacetic and Glutamic Pyruvate Transaminases. Am J Clin Pathol, 28, 1957, 56-63.
- [11]. King EJ, Armstrong AR. A convenient method for determining of Serum and bile phosphatase activity. J Canad Med Asso, 31, 1934, 376-381.
- [12]. Malloy HT, Evelyn KA. The determination of bilirubin with the photometric colorimeter. J Biol Chem, 119, 1937, 481-490.
- [13]. Gornall AG, Bardwill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem, 177, 1949, 751-756.
References
[1]. Schneider AR, Morvan X, Saby NPA, Cances Be, Ponthieu M, Gommeaux M, Marin B. Multivariate spatial analyses of the distribution and origin of trace and major elements in soils surrounding a secondary lead smelter. Environ Sci Pollut Res. 23, 2016, 1–11.
[2]. Lynn S, Shiung JN, Gurr JR, Jan KY. Arsenic stimulates poly (ADPribosylation) by generation of nitric oxide. Free Rad Biol Med. 24, 1998, 442–449.
[3]. AiyerK N, Namboodiri AN, Kolammal M. Pharmacognosy of Ayurvedic Drugs. Series-I. Number-3. The Central Research Institute: University of Travancore; 1957, 57-63.
[4]. Kirtikar KR, Basu BD. Indian medicinal plant. 3,1960, 1702-1712
[5]. Prajapati ND, Purohit SS, Sharma AK, Kumar T. A hand book of Indian Medicinal Plants, A complete Source Book. India, Agrobios, 2003, 291-292.
[6]. Venkataswamy R, Mubarack HM. Ethnobotanical Study of Medicinal plants used by Malasar tribals in Coimbatore District of Tamil Nadu (South India). Asian J Exp Biol Sci, 1 (2), 2010, 387 – 392.
[7]. Jain SK. Dictionary of Indian Folk Medicine and Ethnobotany. Deep Publication, 1991, 108.
[8]. Nishteswar K. Herbs in Vasavarajeeyam. Delhi, Chaukhamba Sanskrit Pratishthan, 2003, 86.
[9]. Arun Kumar, Ranjit Kumar, Mohammad Samiur Rahman, Mohammad Asif Iqubal, Gautam Anand, Pintoo Kumar Niraj and Mohammad Ali. Antidote Effects of Plants of Himalayan Sub-Origin Against Arsenic Induced Toxicity. Biol Chem Res, 2015, 99-109.
[10]. Retimen S, Frankel SA. Colorimetric method for determination of Serum Glutamic Oxaloacetic and Glutamic Pyruvate Transaminases. Am J Clin Pathol, 28, 1957, 56-63.
[11]. King EJ, Armstrong AR. A convenient method for determining of Serum and bile phosphatase activity. J Canad Med Asso, 31, 1934, 376-381.
[12]. Malloy HT, Evelyn KA. The determination of bilirubin with the photometric colorimeter. J Biol Chem, 119, 1937, 481-490.
[13]. Gornall AG, Bardwill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem, 177, 1949, 751-756.