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Apr 26, 2021
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Apr 26, 2021
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Abstract

The present study has been undertaken to evaluate the possible role of Mimusops elengi Linn. flowers in experimental Alzheimer's disease (AD) in rats. Experimental AD in rats was produced by intra cerebro ventricular (i.c.v) administration of colchicine (Col). Various behavioural tests and biochemical analysis were performed to explore the possible role of the Mimusops elengi Linn. flower extract (ME)(100mg/kg & 200mg/kg doses) in AD. ME exhibited anxiolytic activity in Elevated plus maze test. In Morris' water maze test and Brightness discrimination test, ME pretreatments improved reference memory, working memory and spatial learning.ME significantly reduced the acetylcholinestarase. It  reduced the Col induction increased lipid peroxidase activity, which was significantly reversed by ME (as seen from the reductions in the malondialdehyde level) and stabilized the rise in superoxide dismutase activity.ME might be effective in clinical AD by virtue of its cognition enhancement, anti-oxidant and antianxiety properties, which are the primary needs to be addressed in AD.

Keywords

Alzheimer′s disease Anxiolytic activity Colchicine Rats Mimusops elengi Linn

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Bhukya Ramesh, & Santhosh Pawar V. (2021). Evaluation of alzhiemer’s disease of mimusops elengi linn. in the experimental model of rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 4(4), 446-454. https://doi.org/10.61096/ijrpp.v4.iss4.2015.446-454
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