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Apr 26, 2021
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Apr 26, 2021
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Abstract

Ethnopharmacological relevance


Seeds of Coriandrum sativum L. have been used in the Indian traditional medicine to relieve stress and other neurological disease conditions.


Aim of the study


The present study was under taken to evaluate the anxiolytic effects of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) in mice.


Materials and methods


Seeds of Coriandrum sativum L. Ethanolic extract was screened for anxiolytic effect by using Rota rod test, Open field test and Hole board test at doses of 100 and 200 mg/kg. Distilled water and Diazepam were employed as negative and positive control groups, respectively.


Results


Anxiolytic like activity assessment of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) 200 mg/kg by using rota rod test shows significantly decrease in performance time (124) as compared to standard (110) and control (150) treatment group. While open field test of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) 200 mg/kg shows significantly decrease in number of square crossing (21) as compared to standard (15) and control (28) treatment group. Hole board test of seeds of Coriandrum sativum L. Ethanolic Extract (CSEE) 200 mg/kg shows significantly decrease in number of head dipping (09) as compared to standard (07) and control (14) treatment group.


Conclusion


The results of this study established a support for the traditional usage of seeds of Coriandrum sativum L. as anxiolytic medicinal plant.

Keywords

Anxiolytic Rota rod Open field Hole board Coriandrum sativum L

Article Details

How to Cite
Dr. Aslam Pathan, & Dr. Abdulrahman Alshahrani. (2021). In vivo neurological assessment of serotonergic response of Coriandrum sativum L seeds in mice. International Journal of Research in Pharmacology & Pharmacotherapeutics, 4(4), 399-405. https://doi.org/10.61096/ijrpp.v4.iss4.2015.399-405
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