Main Article Content
Abstract
Artocarpus heterophyllus Lam commonly known as jack fruit widely distributed in north east India, West Bengal and south Karnataka. Artocarpus heterophyllus containing polyphenolic compound like flavonoids and tannins and these components are known to possess anti-oxidant properties. In addition there are reports that, free radicals are involved in causation of ulcers. In the present studies the effect of methanolic and aqueous extracts of Artocarpus heterophyllus bark, were studied on hard liquor (90% ethanol), and Pylorus ligation induced ulcer in rats. The reduction in ulcer index dose dependently in hard liquor induced ulcer and in pylorus ligation induced ulcer, by 100 and 200mg/kg body weight doses respectively by the extracts of Artocarpus heterophyllus proving its anti-ulcer activity.
Keywords
Article Details
References
- [1]. Vaidyaratnam PS. Indian medicinal plants a compendium of 500 species. Orient Longman Ltd, 1993(1): 208.
- [2]. Asima Chatterjee, Satyesh Chandra Pakrashi. Vol 2. The treatise on Indian Medicinal Plants, New Delhi: Publications and Information Directorate, 1995 (1): 37.
- [3]. Mrs. Prema Veeraraghavan. Expert consultant, CPCSEA, OECD guideline No. 420
- [4]. Siddhartha Pal, Nag Chaudhuri AK. Studies on the anti-ulcer activity of Bryophyllum pinnatum leaf extract in experimental animals. J Ethnopharmacol 1991; 33: 97-102.
- [5]. Akilandeswari S, Sivakami Sundari P, Ganapaty S. Anti-ulcer activity of Elephantopus scaber Linn. Ad Pharmacol Toxicol 2001; 2(2): 39-40.
- [6]. Mahendran P, Sabitha KE, Shyamal Devi CS, Prevention of HCl-ehtanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. J Expl Biol 2002: 58-62.
- [7]. Mei-Ing Chung, Chai-Ming Lu, Pao-Lin Huang, Chun-Nan Lin. Prenylflavonoids of Artocarpus heterophyllus. Phytochem 1995; 40(4): 1279-82.
- [8]. Chai-Ming Lu, Chun-Nan Lin. Two 2',4',6'-trioxygenated flvonones from Artocarpus heterophyllus. Phytochem 1993; 33(4): 909-11.
- [9]. Sannomiya M, Vitor B Fonseca, da Silva MA, Rocha LRM, dos Santos LC, Hiruma-Lima CA, et al. Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts. J Ethnopharmacol 2005; 97: 1-6.
- [10]. Feng N Ko, Zhi J Cheng, Chun N Lin, Che M Teng. Scavenger and antioxidant properties of prenylflavones isolated from Artocarpus heterophyllus. Free Radl Biol Med. 1998; 25(2): 160-68.s
References
[1]. Vaidyaratnam PS. Indian medicinal plants a compendium of 500 species. Orient Longman Ltd, 1993(1): 208.
[2]. Asima Chatterjee, Satyesh Chandra Pakrashi. Vol 2. The treatise on Indian Medicinal Plants, New Delhi: Publications and Information Directorate, 1995 (1): 37.
[3]. Mrs. Prema Veeraraghavan. Expert consultant, CPCSEA, OECD guideline No. 420
[4]. Siddhartha Pal, Nag Chaudhuri AK. Studies on the anti-ulcer activity of Bryophyllum pinnatum leaf extract in experimental animals. J Ethnopharmacol 1991; 33: 97-102.
[5]. Akilandeswari S, Sivakami Sundari P, Ganapaty S. Anti-ulcer activity of Elephantopus scaber Linn. Ad Pharmacol Toxicol 2001; 2(2): 39-40.
[6]. Mahendran P, Sabitha KE, Shyamal Devi CS, Prevention of HCl-ehtanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. J Expl Biol 2002: 58-62.
[7]. Mei-Ing Chung, Chai-Ming Lu, Pao-Lin Huang, Chun-Nan Lin. Prenylflavonoids of Artocarpus heterophyllus. Phytochem 1995; 40(4): 1279-82.
[8]. Chai-Ming Lu, Chun-Nan Lin. Two 2',4',6'-trioxygenated flvonones from Artocarpus heterophyllus. Phytochem 1993; 33(4): 909-11.
[9]. Sannomiya M, Vitor B Fonseca, da Silva MA, Rocha LRM, dos Santos LC, Hiruma-Lima CA, et al. Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts. J Ethnopharmacol 2005; 97: 1-6.
[10]. Feng N Ko, Zhi J Cheng, Chun N Lin, Che M Teng. Scavenger and antioxidant properties of prenylflavones isolated from Artocarpus heterophyllus. Free Radl Biol Med. 1998; 25(2): 160-68.s