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Apr 22, 2021
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Apr 22, 2021
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Abstract

Syzygium cumini. Linn Leaves were widely used as good medication for several diseases like antimicrobial, cancer, antihypertensive etc.


Aim: The main goal of our study was to explore the acute and sub-chronic oral toxic effects of Ethanolic Extract of Syzygium cumini. Linn Leaves on experimental animals.


Materials and methods: Acute toxicity study was carried out by following OECD guideline no. 423. The different doses like 500, 1000, 2000, 3000, 4000 and 5000mg/Kg body weight were administered orally to the different groups of animals and observed for 24 hr after dosing and also observed for 14 days without giving drug. In sub-chronic oral toxicity study, the parameters were after administering daily oral doses of 1250, 2500 and 5000 mg/kg body weight for 28 days to the rats.


Results: Body weights of the rats observed weekly and Biochemical, hematological, histopathological assessments and relative organ weights of the rats were observed on 29th day.


Conclusion: By observing the hematological, biochemical parameters and the histopathological studies it is finally concluded that Ethanolic extract of Syzygium cumini leaves produces severe inflammation and fibrosis on Liver at oral doses of 1250, 2500 and 5000mg/kg body weight.

Keywords

Syzygium cumini. Linn Leaves Acute and Sub Chronic toxicity EESCL Hematology Histopathology

Article Details

How to Cite
M. Sekar, C.Ayyanna, R. Niranjan Kumar, A. Siva kumar, G. Madhavi lakshmi, & N.Siva Mallika Supraja. (2021). Hepatotoxic effect of ethanolic extract of syzygium cumini. Linn leaves on experimental animals. International Journal of Research in Pharmacology & Pharmacotherapeutics, 4(3), 288-294. https://doi.org/10.61096/ijrpp.v4.iss3.2015.288-294
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