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Abstract
Sydnones are proved to be important members of the meso-ionic system and are studied extensively for their pharmacological activities. In the present study several newly synthesized sydnones have been investigated for their anti-inflammatory effect. In the present study experiments for both acute and chronic anti-inflammatory activity were carried out viz., Carrageenan induced rat paw edema inhibition test to study the acute anti-inflammatory activity and cotton pallet granuloma inhibition test to study the chronic anti-inflammatory activity. These meso-ionic compounds-sydnones have been shown to possess anti-inflammatory. Among the various substituted thiazolyl thiourea sydnones 10 compounds were tried initially employing Carrageenan induced rat paw edema inhibition test for picking up an agent with anti-inflammatory activity. Compounds 3, 6, 8 and 9 which have shown considerable acute anti-inflammatory activity
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References
- 1. U.S. Hiremath, C.V. Yelamaggad and B.V. Badami, Indian J. Heterocycl. Chem. 5, 19 (1995).
- 2. W.L. Chan, Y. Hua and Y.S. Szeto, Materials Lett., 58, 882 (2004).
- 3. Baker W, Ollis WD, Poole VD. Cyclic meso-ionic compounds. Part 1, the structure of sydnones and related compounds. J. chem. soc.307,1949
- 4. Masuda K, Kamitani T. Chem. Abst 73 87922 f;1970
- 5. Kier LR, Roche EB. J. Pharm. Sci.56 149;1967
- 6. Steele JW, Anderso WK, Trager WF. Can .J .Pharma.Sci. 7, 103; 1972.
- 7. Ota M.Japan 70, 14069; Chem. Abst. 73, 77241 u; 1970.
- 8. Cotton RS ,Kumar V and Robbins Sl. Robbins pathologic basis of disease.5th edn Philadelphia B Sauderers company ,1994.p.53-4
- 9. Ritchie A C. Boyd’s textbook of pathology, Canada, edn 9, USA; lea and feberger, 1990:p.60-88, 1044.
- 10. Dey NC, Debashish S, Pey PK edn. Textbook of pathology; New central book agency ltd,19995:p.6.1-6.59
- 11. Rubin E. Essential pathology, 2nd edn, Chapter-2 inflammation, Philadelphia: Lippincort Williams & Wilkins, 2001: p-24-46.
- 12. Satoskar RS, Bhandarkar SD, Ainapur SS, Angiotensin, Kinins, Leukotrienes prostaglandins and cutokiones, 18th edn. Bombay India; Popular Prakashan pvt. Ltd. 2003 p 333-9
- 13. Tripathi KD. Essentials of medical pharmacology, 5th edn .prostaglandin Leukotrienes, jaypee pub Pvt Ltd, 2004 P 156-166
- 14. Regoli D and J. Barbe. Pharmacology of bradykinin and related Kinins. Pharmacol res. 1990; 32:1-146.
- 15. C.V. Yelamaggad, M .Mathews, U.S. Hiremath, D.S.S. Rao and S.K. Prasad, Tetrahedron Lett., 46, 2623 (2005).
- 16. Chattopadhyay RR, Chattopadhyay RN, Maitra SK, Possible mechanism of anti-inflammatory activity of Azadrachta indica leaf extract, Ind J pharmacol, 1993; 25:99-100
- 17. Winter CA, Risley ES, Noss GW. Carregennan induce oedema in hind paw of rat as assay for anti-inflammatory drugs. Proc soc exp bio med, 1962; 111:544-547.
- 18. Turner R A. Screening methods in pharmacology, Newyork and London. Academic press inc., 1965; p.323
- 19. Bhabagrahi R, effect of neem lead extract (NLE) on cotton pellet granuloma in Albino rats. Ind J Pharmacol, 2002; 34: 297-8.
- 20. Meier R, Sculler W, Desaulles. Pzur frag des: mechanism der humang des bindegewebswachstuma durch cortisone. Experimentia. 6. p.469-71;1950
- 21. Finney RSH, Somers GR. The anti-inflammatory activity of glycerrhetinic acid and derivatives. J Pharm. Pharmacol. 10, P.613-20;1958
- 22. Upadhaya KG, Badami BV, Puranik GS. Arch.Pharma (Weinhem) 313, p.680, 1980
References
1. U.S. Hiremath, C.V. Yelamaggad and B.V. Badami, Indian J. Heterocycl. Chem. 5, 19 (1995).
2. W.L. Chan, Y. Hua and Y.S. Szeto, Materials Lett., 58, 882 (2004).
3. Baker W, Ollis WD, Poole VD. Cyclic meso-ionic compounds. Part 1, the structure of sydnones and related compounds. J. chem. soc.307,1949
4. Masuda K, Kamitani T. Chem. Abst 73 87922 f;1970
5. Kier LR, Roche EB. J. Pharm. Sci.56 149;1967
6. Steele JW, Anderso WK, Trager WF. Can .J .Pharma.Sci. 7, 103; 1972.
7. Ota M.Japan 70, 14069; Chem. Abst. 73, 77241 u; 1970.
8. Cotton RS ,Kumar V and Robbins Sl. Robbins pathologic basis of disease.5th edn Philadelphia B Sauderers company ,1994.p.53-4
9. Ritchie A C. Boyd’s textbook of pathology, Canada, edn 9, USA; lea and feberger, 1990:p.60-88, 1044.
10. Dey NC, Debashish S, Pey PK edn. Textbook of pathology; New central book agency ltd,19995:p.6.1-6.59
11. Rubin E. Essential pathology, 2nd edn, Chapter-2 inflammation, Philadelphia: Lippincort Williams & Wilkins, 2001: p-24-46.
12. Satoskar RS, Bhandarkar SD, Ainapur SS, Angiotensin, Kinins, Leukotrienes prostaglandins and cutokiones, 18th edn. Bombay India; Popular Prakashan pvt. Ltd. 2003 p 333-9
13. Tripathi KD. Essentials of medical pharmacology, 5th edn .prostaglandin Leukotrienes, jaypee pub Pvt Ltd, 2004 P 156-166
14. Regoli D and J. Barbe. Pharmacology of bradykinin and related Kinins. Pharmacol res. 1990; 32:1-146.
15. C.V. Yelamaggad, M .Mathews, U.S. Hiremath, D.S.S. Rao and S.K. Prasad, Tetrahedron Lett., 46, 2623 (2005).
16. Chattopadhyay RR, Chattopadhyay RN, Maitra SK, Possible mechanism of anti-inflammatory activity of Azadrachta indica leaf extract, Ind J pharmacol, 1993; 25:99-100
17. Winter CA, Risley ES, Noss GW. Carregennan induce oedema in hind paw of rat as assay for anti-inflammatory drugs. Proc soc exp bio med, 1962; 111:544-547.
18. Turner R A. Screening methods in pharmacology, Newyork and London. Academic press inc., 1965; p.323
19. Bhabagrahi R, effect of neem lead extract (NLE) on cotton pellet granuloma in Albino rats. Ind J Pharmacol, 2002; 34: 297-8.
20. Meier R, Sculler W, Desaulles. Pzur frag des: mechanism der humang des bindegewebswachstuma durch cortisone. Experimentia. 6. p.469-71;1950
21. Finney RSH, Somers GR. The anti-inflammatory activity of glycerrhetinic acid and derivatives. J Pharm. Pharmacol. 10, P.613-20;1958
22. Upadhaya KG, Badami BV, Puranik GS. Arch.Pharma (Weinhem) 313, p.680, 1980