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Apr 21, 2021
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Apr 21, 2021
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Abstract

Aim of the study


The present study is undertaken to study the cardiotonic activity and its protective role on heart by Paederia foetida belonging to the family Rubiaceae.


Materials and Methods


Paederia foetida leaf extracts with ethanol and hydro alcoholic (aq. Methanol) as solvents is prepared by maceration for 72h. Both the extracts have shown presence of cardiac glycosides, iridoids glycosides, alkaloids, flavonoids, tannins, phytosterols and aminoacids on phytochemical screening. These extracts PFEE and PFHE were screened for cardio tonic activity by "Isolated Frog Heart Perfusion Technique" and protective role studies by using Isoproterenol induced cardio toxicity in Wistar albino rats by administering PFEE and PFHE (200mg/kg) for a period of 14 days and Isoproterenol on 15th day (5.25mg/kg) and 16th day (8.5mg/kg) subcutaneously. Cardio protection was assessed by estimating the cardiac marker enzymes Aspartate dehydrogenase, Alanine dehydrogenase, Creatine Kinase MB, Lactate dehydrogenase and Total Protein levels in serum and heart tissues. Biochemical studies of assay of Na+K+ATPase, Ca2+ATPase and Mg2+ATPase were performed by administering the extracts 200mg/kg orally for a period of 7 days.


Results


Paederia foetida extracts has produced significant positive inotropic and negative chronotropic effect similar to that of standard drug digoxin. These effects were antagonized in presence of nifedipine but not with propranolol. A significant (p<0.05) decrease in membrane Na+K+ATPase and Mg2+ATPase and an increase in Ca2+ATPase on comparison to normal control, further confirmed its cardiotonic activity. The levels altered by isoproterenol were restored significantly (p<0.05) by the administration of the extracts both in serum and heart tissue levels. This activity can be attributed due to presence of particular cardiac glycosides and iridoids glycosides which can further processed.


Conclusion


Our work clearly shows that Paederia foetida possesses cardio tonic activity without altering the normal physiology of heart.

Keywords

Cardiotonic digoxin Paederia foetida membrane bound enzymes

Article Details

How to Cite
Tejaswi Burra, Raju Bairi, & Vijay kumar Kusuma. (2021). Evaluation of Cardiotonic and Cardioprotective Effects of Paederia foetida. International Journal of Research in Pharmacology & Pharmacotherapeutics, 4(2), 231-244. https://doi.org/10.61096/ijrpp.v4.iss2.2015.231-244
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