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Apr 19, 2021
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Apr 19, 2021
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Abstract

Aim                                                                                  


To study the antiobesity and anticoagulant activity of ethanol extract of Trigonella foenum-graecum  L.  (Fenugreek) in male wistar rats.


Methods


Trigonella foenum-graecum  L. was first extracted with ethanol and subjected to phytochemical analysis and its anti-obesity activity was studied in male wistar rats by feeding with cafeteria diet for 42 days in diet induced model and by administering a single intra peritoneal injection of Triton X-100 in chemical induced model. In diet induced model, weight of the animals was measured once in a week and parameters like total cholesterol (TC), triglycerides (TG), LDL, VLDL, HDL levels, clotting time were measured on 43rd day. In chemical induced model, the above parameters were measured on 8th day.


Results and Discussion


Preliminary phytochemical analysis revealed the presence of saponins, flavonoids, phyosterols, alkaloids, cardiac glycosides, coumarin glycosides, proteins and tannins & phenolic compounds. Significant increase in body weight, TC, TG, LDL, VLDL levels and reduction in HDL levels and clotting time was seen in animals fed with cafeteria diet. Treatment with standard drug orlistat and fenugreek extract significantly suppressed the increase in body weight and normalized the lipid levels and prolonged the clotting time.


Conclusion


From the results, it could be concluded that the ethanol extract of Trigonella foenum-graecum L. had significant anti-obesity and anticoagulant activity by maintaining the normal levels of physical and biochemical parameters and by prolonging the clotting time.

Keywords

Trigonella foenum-graecum L cafeteria diet obesity clotting time orlistat body weight total cholesterol

Article Details

How to Cite
Thoutreddy Radhika, Raju Bairi, & G. Mounika. (2021). Anti-obesity and anticoagulant activity of ethanol extract of Trigonella foenum-graecum L. International Journal of Research in Pharmacology & Pharmacotherapeutics, 4(1), 119-125. https://doi.org/10.61096/ijrpp.v4.iss1.2015.119-125
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