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Abstract
Rheumatoid arthritis is a chronic systemic inflammatory disorder affecting joints leading to limited range of motion affecting daily activities. Various drug therapies were used to preserve range of motion; joint function and to prevent systemic complications.
But due to serious adverse effects of the drugs and limited improvement a 'Novel drug free implant' is introduced to improve quality of life and reduce adverse effects of the drugs. This drug free implant works through electric stimulation of peripheral nerve as a treatment for immune disease.
This article is a review on assessing various drugs used to treat Rheumatoid arthritis comparing it's efficacy and advantages of 'Drug free implant' over other drug therapy. It is assessment of various anti-rheumatic drugs related adverse effects and safety profile.
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References
- [1] Iain B. McInnes and Georg Schett "The Pathogenesis of Rheumatoid Arthritis" N Engl J Med 2011; 365:2205-2219.
- [2] Kumar P1, Banik S. "Pharmacotherapy options in rheumatoid arthritis." Clin Med Insights Arthritis Musculoskelet Disord. 8;6:35-43
- [3] Ronald F. van Vollenhoven, Roy Fleischmann, Stanley Cohen, Eun Bong Lee, "Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis".
- [4] James R. O’Dell, Ted R. Mikuls,. Thomas H. Taylor, Vandana Ahluwalia Warren, J.D., "Therapies for Active Rheumatoid Arthritis after Methotrexate Failure" N engl j med 369;4.
- [5] 5. Takeda K1, Kaisho T, Akira S. Toll-like receptors." Annu Rev Immunol.
- [6] Madhusudan S, Muthuramalingam SR, Braybrooke JP, et al "Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer". J. Clin. Oncol. 23 (25): 5950–9.
- [7] Michael E. Weinblatt,, Arthur Kavanaugh Mark C. Genovese "An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis" N engl j med 363;14
- [8] Article by Kevin J trace
- [9] Research article by Susan young rojhan on August 22, 2013
- [10] Chris Vaillancourt" Implantable Pulse Generators ‘Stimulate’ Medical Device'
- [11] James R.O`Dell ."Therapies for Active Rheumatoid Arthritis after Methotrexate Failure". N Engl J Med 2013;369:307-18.
- [12] Michael E. Weinblatt,. "An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis". N Engl J Med 2010;363:1303-12.
- [13] Ronald F. van vollenhoven, "Tofacitinib or adalimumab versus placebo in Rheumatoid Arthritis", N Engl J Med 2012;367:508-16
- [14] Susan Young Rojahn. "A nerve-stimulating electrical implant could give people a drug-free alternative to current treatments." August 22, 2013.
- [15] Ulf Andersson, "A New Approach to Rheumatoid Arthritis: Treating Inflammation with Computerized Nerve Stimulation". . August 22, 2013.
References
[1] Iain B. McInnes and Georg Schett "The Pathogenesis of Rheumatoid Arthritis" N Engl J Med 2011; 365:2205-2219.
[2] Kumar P1, Banik S. "Pharmacotherapy options in rheumatoid arthritis." Clin Med Insights Arthritis Musculoskelet Disord. 8;6:35-43
[3] Ronald F. van Vollenhoven, Roy Fleischmann, Stanley Cohen, Eun Bong Lee, "Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis".
[4] James R. O’Dell, Ted R. Mikuls,. Thomas H. Taylor, Vandana Ahluwalia Warren, J.D., "Therapies for Active Rheumatoid Arthritis after Methotrexate Failure" N engl j med 369;4.
[5] 5. Takeda K1, Kaisho T, Akira S. Toll-like receptors." Annu Rev Immunol.
[6] Madhusudan S, Muthuramalingam SR, Braybrooke JP, et al "Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer". J. Clin. Oncol. 23 (25): 5950–9.
[7] Michael E. Weinblatt,, Arthur Kavanaugh Mark C. Genovese "An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis" N engl j med 363;14
[8] Article by Kevin J trace
[9] Research article by Susan young rojhan on August 22, 2013
[10] Chris Vaillancourt" Implantable Pulse Generators ‘Stimulate’ Medical Device'
[11] James R.O`Dell ."Therapies for Active Rheumatoid Arthritis after Methotrexate Failure". N Engl J Med 2013;369:307-18.
[12] Michael E. Weinblatt,. "An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis". N Engl J Med 2010;363:1303-12.
[13] Ronald F. van vollenhoven, "Tofacitinib or adalimumab versus placebo in Rheumatoid Arthritis", N Engl J Med 2012;367:508-16
[14] Susan Young Rojahn. "A nerve-stimulating electrical implant could give people a drug-free alternative to current treatments." August 22, 2013.
[15] Ulf Andersson, "A New Approach to Rheumatoid Arthritis: Treating Inflammation with Computerized Nerve Stimulation". . August 22, 2013.