Article Sidebar

Submitted
Apr 16, 2021
Published
Apr 16, 2021
Download
PDF
Statistic
Read Counter : 42 Download : 25

Main Article Content

Abstract

Bauhinia variegata Linn. (Leguminosae) is commonly known as 'Chemmandharai' in Hindi. It is distributed almost throughout India. Its powdered root and stem bark is traditionally used for tonic and ulcers. It is also useful in skin diseases. The roots are used as antidote to snake poison. NSAIDs are one of the most widely used categories of drugs presently and there are many clinical situations where one needs to use them for fairly long periods. A literature survey of herbs with anti-inflammatory effects led to Bauhinia variegata which was quoted in the Ayurvedic literature as having many therapeutic activities. Lot of research work is reported on this plant but the root and stem bark was not evaluated for anti-inflammatory activities. A hydro ethanolic extract was prepared and evaluated for anti-inflammatory activity using conventional pharmacological animal models. The results indicated that the bark extract at a dose of 200mg/kg showed significant anti-inflammatory activity compared to the root extracts and control group.

Keywords

NSAIDs Bauhinia variegata anti-inflammatory stem bark

Article Details

How to Cite
Dr.Bijoy Chirayath, N.Sriram, & Chatlapelli Kishore. (2021). Anti-inflammatory activity of root and stem bark of Bauhinia variegata. International Journal of Research in Pharmacology & Pharmacotherapeutics, 4(1), 49-52. https://doi.org/10.61096/ijrpp.v4.iss1.2015.49-52
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. [1] Rao K., Nigam MC. (1976) Indigenous herbs of potential value having curative properties. Indian drugs, 14(3): 59.
  2. [2] Singh PB and Aswal. B.S. (1992) Medicinal plants of Himachal Pradesh used in Indian pharmaceutical industry. Bull. Med. Ethnobot. Res. 13: 172-208.
  3. [3] Bakhru HC. (1997) Herbs that heal I Orient Longman Ltd, New Delhi, 17
  4. [4] Balajirao N.S, Rajasekhar D, Narayana R and D. Raju. (1995) Ethno-medical therapy among the Chenchus of Nallamalai forest of Andhra Pradesh. Biosci. Res. Bull. 11:81-5.
  5. [5] Hardman JG, Limbird LE and Gillman GA, (2001) Goodman and Gilman’s the Pharmacological Basis of Therapeutics, Mc-Graw Hill Medical Publishing Division USA, 10th Edn, pp. 687-707.
  6. [6] Chrubasik, J.E., B.D. Roufogalis and S. Chrubasik, 2007. Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytother.Res, 21:675-683.
  7. [7] Dinarello, C.A., 2006. Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am. J. Clin. Nutr, 83:447S-455S.
  8. [8] Khan, M.N., J.S. Choi, M.C. Lee, E. Kim, T.J. Nam, H. Fujii and Y.K. Hong, 2008. Anti-inflammatory activities of methanol extracts from various seaweed species. J. Environ. Biol., 29: 465-469.
  9. [9] Gerhard vogal H, Drug discovery and Evaluation, pharmacological assays 2nd edition. Pg 716.
  10. [10] Kirtikar K.R,B.D.Basu, Indian Medicinal Plants, (International Book Distributor, Dehradun, 1999) pp. 892-901.
  11. [11] OECD/OECD Guidelines for the testing of chemicals, Revised Draft Guidelines 423; acute oral toxicity-acute toxic class method revised document, October 2000.
  12. [12] Pandit RK, Suresh K. (1992) Kanchnarguggulu- A critical review. Journal of research and Education in Indian Medicine11 (3): 39-42.
  13. [13] Parmar N.S, Shiv Prakash, 2006 screening methods in Pharmacology, Pg: 213-33.
  14. [14] Yadava R.N and V.M. Reddy. (2003) Anti-inflammatory activity of a novel flavonolglycoside from the Bauhinia variegata Linn. J.Nat.Prod.Res.17 (3): 165.