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Abstract
Syzygium alternifolium a member of the Myrtaceae family, is used in fruit is used for curing stomach ache, ulcers and management of rheumatic pains; seeds as anti-diabetic agents; leaves to treat dry cough and dysentery; and stem bark as antiseptic. The purpose of the present study is to investigate the acute oral toxicity and anti-ulcer profile of the Ethanol Extract of Syzygium alternifolium (ESA) extract in albino rats. No toxicity of extract up to 2000mg/kg body weight orally as per OECD guidelines No.423. ESA at the doses of 250 and 500 mg/kg body weight orally was administered to evaluate anti-ulcer activity by using Ethanol and indomethacin, induced gastric ulcer models in Albino rats. Ethanol Extract of Syzygium alternifolium dose dependent inhibition in ethanol induced gastric lesions, causing 68.04% protection at 500 mg/kg, and 54.74% protection at 250 mg/kg, ESA dose dependent inhibition in indomethacin induced gastric lesions, causing 65.14% protection at 500 mg/kg and 54.13% protection at 250 mg/kg, All the results are found to be statistically significant (p≤0.05). Hence we suggest that Ethanol Extract of the fruit of Syzygium alternifolium could decrease the acidity and to increase the mucosal defense in the gastric areas, thereby justifying its use as an anti ulcerogenic agent.