ANTIPYRETIC ACTIVITY OF WHOLE PLANT OF LEPIDAGATHIS CRISTATA WILLD. IN BREWER’S YEAST INDUCED HYPER PYREXIA RATS

Abstract

The objective of the present work was to study the antipyretic activity of whole plant of Lepidagathis cristata Willd, belongs to family Acantahaceae. The Petroleum ether extract was taken for the study and evaluated for antipyretic activity using Brewer’s yeast induced pyrexia in Wister strain albino rats. The Petroleum ether extracts at a dose of 100mg/kg & 200mg/kg were evaluated for antipyretic activity. The extract of Lepidagathis cristata plant showed a significant (P < 0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. The Petroleum ether extracts of Lepidagathis cristata plant have significant antipyretic activity when compared with the standard drug.