International Journal of Research in Pharmacology & Pharmacotherapeutics
type: channel
description: Welcome to IJRPP, International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) is a peer-reviewed, Quarterly official international journal allowing access to abstracts and full-text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines (Pharmacology, Biopharmaceutics, Pharmacokinetics, Pharmaceutical Medicinal Chemistry, Computational Chemistry & Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmaceutical Analysis, Pharmacy Practice, Clinical & Hospital Pharmacy, Cell Biology, Genomics & Proteomics, Pharmacogenomics, Bioinformatics including biotechnology, cell & molecular biology, Pharmaceutical biotechnology/microbiology, medical and other life sciences). ISSN - International Journal of Research in Pharmacology & Pharmacotherapeutics Online : 2278-2656 Print : 2278-2648 International Journal of Research in Pharmacology & Pharmacotherapeutics seeks to foster multidisciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide an international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance. All manuscripts will be subjected to rapid peer review. Those of high quality (not previously published and not already under consideration for publication) will be published. EDITOR.
publisher: Futuristic Publications, 408, Sai Satya Nilayam, Road No.1, Shankar Nagar, Peerzadiguda, Hyderabad-500039, Telangana.
language: en
publication name: International Journal of Research in Pharmacology & Pharmacotherapeutics
issn: 2278-2656
items: Metformin: A revolutionary drug that halts the aging process, keeping you youthful indefinitely
items: Notch Signalling in Liver Disease: A Comprehensive Analysis
items: Evaluation Of Medication Adherence In Patients With Hypertension
items: In-Vitro Evaluation Of Anti-Oxidant Activity Of Coccinia Indica Leaves
items: Evaluation Of Anti-Psychotic Effect Of Mentha Arvensis L Leaves In Apomorphine Induced Psychosis In Rats
items: A Study On Pain Assessment And Management In Total Knee Replacement Patients
items: In Vivo Anti Diabetic Activity Of Helicteres Isora On Streptozotocin-Induced Diabetic In Rats
items: Comprehensive Review of Diabetes Mellitus: Current Perspectives, Challenges, and Emerging Frontiers
items: Study on Assessment of Drug Compliance in Diabetic Patients in Rural Area of Dharmapuri District Tamilnadu
items: The Role Of Immunostimulants In Improving The Immunity In Autoimmune Diseases
items: A comprehensive analysis of the risk variables linked to HIV infection
items: Pharmacist Intervention in early detection and prevention of Mi Risk Among Adults
items: Unlocking the potential of stem cell therapy for Autism: A new era in neurotherapeutics
items: Contemporary Strategies In The Pharmacological Management Of Hypertension
items: Role of gabaergic Drugs in the Treatment of Anxiety and Epilepsy
items: Navigating The Pharmacological Landscape Of Asthma Management: Current And Future Trends
items: Exploring the Adaptogenic Power of Withania somnifera: Mechanisms of Stress Alleviation and Implications for Mental Health and Wellness
items: A Review of Cardioprotective Properties of Various Medicinal Plants
items: A Case Report On Montelukast And Fexofenadine Induced Depression And Nightmares
items: A Case Report On Donepezil Induced Cervical Dystonia
items: Escitalopram-Induced Hyponatremia and Neurological Adverse Effects: A Case Series
items: Phytoniosomal gel of acalypha indica: a novel topical delivery system for anti-inflammatory activity
items: Formulation and evaluation of herbal tablet from moringa Oleifera leaves
items: A retrospective study on prescription patterns and therapeutic approaches for various cancer chemotherapies in tertiary care hospital, Narasaraopet
items: Different Roles of Pharmacists As A Health Care Professionals
items: A brief overview of Chandipura virus
items: A review on dicarboxylic acids and their derivatives used to treat diabetes
items: A Comprehensive Overview On Pharmacovigilance Ensuring Drug Safety
items: Drug Safety in Pregnancy and Lactation: A Review of Current Guidelines
items: The Usage Of Biomarkers In The Early Detection Of Diseases

Metformin: A revolutionary drug that halts the aging process, keeping you youthful indefinitely
type: item
description: The most often given oral hypoglycaemic drug for type 2 diabetes globally is metformin, a biguanide anti-diabetic drug that has been around for more than 30 years. Its mode of action wasn't understood till a few years ago. However, it was recently found that through an increased tissue glucose uptake by a transporter-linked system, is now connected to better peripheral sensitivity to insulin. Although it is clear that not all possible effects of metformin use have been identified yet, it is feasible that metformin will become a cornerstone treatment for illnesses associated with ageing and other related conditions such as cancer and neurological diseases in humans. Despite the fact that not everyone using metformin experiences the same advantages, some people do have negative effects. Therefore, it is essential to fully comprehend the mechanism and all potential side effects of this medication. Therefore, this study offers a summary of current advances in metformin's impact on ageing and illnesses linked to it.
subject: Articles
  topic: section
subject: Hypoglycemic
  topic: keywords
subject: metformin
  topic: keywords
subject: ageing
  topic: keywords
subject: insulin
  topic: keywords
creator: Kavinraja. A
creator: Aswin. R
creator: Kameswaran. R
rights: Copyright (c) 0
date: 2025-01-07
publication date: 2025-01-07
starting page: 11
ending page: 15
doi: 10.61096/ijrpp.v14.iss1.2025.11-15

Notch Signalling in Liver Disease: A Comprehensive Analysis
type: item
description: Notch signaling is an evolutionarily conserved cell–cell communication pathway that exerts broad regulatory functions across numerous developmental and pathophysiological contexts. In the liver, Notch signaling intricately controls hepatobiliary differentiation, biliary homeostasis, and regenerative processes. Dysregulated Notch activity underlies the pathogenesis of diverse liver diseases, including cholangiopathies, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatocellular carcinoma (HCC), and cholangiocarcinoma (CCA). This manuscript provides a comprehensive overview of Notch biology in the liver, highlighting molecular mechanisms of pathway activation, cross-talk with other signaling cascades, and the resultant outcomes in both normal physiology and disease states. Emphasis is placed on recent advances that delineate how aberrant Notch signaling contributes to cholangiocyte proliferation, fibrogenesis, hepatic steatosis, and tumorigenesis. Furthermore, current therapeutic strategies targeting Notch—ranging from γ-secretase inhibitors and monoclonal antibodies to ligand-specific traps and novel gene-based approaches—are discussed in light of their potential benefits and limitations. Emerging evidence suggests that targeted modulation of Notch may offer new possibilities for disease management, either alone or in combination with other targeted therapies. Nonetheless, toxicity and off-target effects pose ongoing challenges, underscoring the need for refined, context-specific interventions. By examining the molecular underpinnings and clinical implications of Notch signaling in liver diseases, this review aims to inform future research directions and therapeutic developments. The ultimate objective is to propel the field toward precision medicine strategies that more effectively leverage Notch pathway modulation for improved patient outcomes in diverse hepatic disorders.
subject: Articles
  topic: section
subject: Notch signaling
  topic: keywords
subject: liver disease
  topic: keywords
subject: cholangiopathies
  topic: keywords
subject: NAFLD
  topic: keywords
subject: NASH
  topic: keywords
subject: hepatocellular carcinoma
  topic: keywords
subject: cholangiocarcinoma
  topic: keywords
creator: Keerthi Birudaraju
creator: Donpal Rajesh
creator: Chennaboina Soumya Chennuri Akshitha
creator: Dugyala Maruthi Sripadha Vallabha
creator: Sai Varsha
rights: Copyright (c) 0
date: 2025-01-16
publication date: 2025-01-16
starting page: 16
ending page: 24
doi: 10.61096/ijrpp.v14.iss1.2025.16-24

Evaluation Of Medication Adherence In Patients With Hypertension
type: item
description: The World Health Organization (WHO) defines medication adherence as the degree to which an individual's behaviour in taking medication aligns with the agreed recommendations of a healthcare provider. In this study, medication adherence refers to the extent to which elderly hypertension patients comply with prescribed drug regimens. In this study, hypertensive refer to elderly patients diagnosed with hypertension and on antihypertensive treatment for at least one month at the study hospital. The study identifies five key factors influencing antihypertensive adherence among the elderly: beliefs and attitudes, therapy, socio-economic status, patient characteristics, and physician-related factor. Methods: Prospective study was conducted in patients with hypertension disease in Narasaraopet. They were randomly approached by sending them the MMAS-8 scale questionary form to Area hospital in Narasaraopet, palnadu. Results: The study included 205 patients, with the majority 88 aged over 60 years. The study demographics revealed 141 female and 64 male patients. Of these, 162 were married, and 43 were unmarried. Regarding education, 88 patients had completed primary school. Additionally, 76 patients had experienced hypertension for 2–6 years. Conclusion: Adherence to antihypertensive medication is essential for effective blood pressure management in the elderly, ensuring therapeutic benefits and maintaining quality health.
subject: Articles
  topic: section
subject: Medication adherence
  topic: keywords
subject: hypertension
  topic: keywords
subject: socio-economics
  topic: keywords
subject: regimens
  topic: keywords
subject: demographics
  topic: keywords
creator: Shaik. Baji
creator: Bommu. Rajasekhar
creator: Pothakamuri. Venkata Lokesh
creator: M. Prasada Rao
rights: Copyright (c) 0
date: 2025-01-16
publication date: 2025-01-16
starting page: 25
ending page: 28
doi: 10.61096/ijrpp.v14.iss1.2025.25-28

In-Vitro Evaluation Of Anti-Oxidant Activity Of Coccinia Indica Leaves
type: item
description: Antioxidants are compounds that can inhibit or prevent the oxidation of the easily oxidized substrate. One of the plants as a potential source of bioactive compounds and antioxidant activity (Coccinia indica). This plant was commonly found in the India has been used by the society. This study aimed to determine the proximate compositions, bioactive compounds and antioxidant activity from large-leafed mangrove fruit which extracted by methanol. The phytochemical screening was carried on the both extracts of leaves of Coccinia indica, revealed the presence of some active ingredients such as Alkaloid, Flavonoids, Tannins, Saponins, Phenols. The aqueous and alcoholic leaves extract were also evaluated for their antioxidant activity using FRAP assay, Metal chelating assay, DPPH radical scavenging assay, superoxide-radical scavenging assay and Hydrogen peroxide scavenging assay. The result of the present study showed that the ethanolic leaves extract of Coccinia indica has shown the greatest anti-oxidant activity than aqueous extracts. The high scavenging property of may be due to hydroxyl groups existing in the phenolic compounds. Further work is needful to isolate the exact compound which is responsible for antioxidant activity and biophysical characterization can be done in the future.
subject: Articles
  topic: section
subject: Coccinia indica and Antioxidant activity
  topic: keywords
creator: Ellendula Bhavya
creator: D. Swathi
creator: V. Umarani
creator: K. Shravankumar
rights: Copyright (c) 0
date: 2025-01-20
publication date: 2025-01-20
starting page: 29
ending page: 41
doi: 10.61096/ijrpp.v14.iss1.2025.29-41

Evaluation Of Anti-Psychotic Effect Of Mentha Arvensis L Leaves In Apomorphine Induced Psychosis In Rats
type: item
description: Psychotic disorders, including schizophrenia, significantly impact individuals' mental health, necessitating innovative therapeutic approaches. This study evaluates the antipsychotic potential of ethanolic extracts of Mentha arvensis L. leaves through apomorphine-induced psychosis in rats. The extract's phytochemical profile revealed the presence of alkaloids, flavonoids, and phenols, among others, indicating its bioactive potential. In vitro antioxidant assays demonstrated notable nitric oxide and superoxide anion scavenging activities, suggesting its neuroprotective properties. Behavioral studies, including the pole climbing and catatonic tests, highlighted significant improvements in motor coordination and reduced catatonic symptoms with the extract, especially at 200 mg/kg. Biochemical analyses indicated a restorative effect on dopamine levels and modulation of monoamine oxidase (MAO-A and MAO-B) activities, reflecting its potential mechanisms of antipsychotic action. These findings align with traditional medicinal uses of Mentha arvensis for mental health. The results underscore the therapeutic promise of Mentha arvensis in managing psychosis, with implications for its use as a natural adjunctive treatment. Further research is needed to isolate active compounds, understand molecular mechanisms, and assess safety and efficacy in clinical settings. This study highlights the integration of phytochemical and pharmacological approaches to uncover novel antipsychotic agents.
subject: Articles
  topic: section
subject: Mentha arvensis
  topic: keywords
subject: psychosis
  topic: keywords
subject: antipsychotic activity
  topic: keywords
subject: dopamine modulation
  topic: keywords
subject: oxidative stress
  topic: keywords
creator: R. Krishnan
creator: G. Muthukumaran
rights: Copyright (c) 0
date: 2025-01-20
publication date: 2025-01-20
starting page: 42
ending page: 53
doi: 10.61096/ijrpp.v14.iss1.2025.42-53

A Study On Pain Assessment And Management In Total Knee Replacement Patients
type: item
description: Introduction: Pain is subjective in nature. It can express different manners by the patient (or) Individuals. The role of diagnostic pain procedures is considered very important. It can be classified into acute pain (i.e ; short lived pain)and chronic pain (i.e; pain that lasts for months). It shows effect on socio economic status of the patients. Poor pain management is likely to persist until pain management practices became consistent with guidelines developed from the best available scientific evidence. Method: We conducted a single centered observational analysis of adults age 45years undergone Total knee replacement surgery during six months at Area Hospital, Palnadu road, Narasaraopet. Pain assessment was assessed by facial pain scale Results: A long proportion of 78 patients had undergone TKR. Pain assessment is done by using facial pain assessment scale. Male patients have mild pain (3 points) at the time of discharge. Female patients have moderate pain (4 points) after the surgery. Conclusion: Pain assessment plays a major role in the management of chronic and acute pain. Articular damage belongs to unsteadiness of the involved knee was a source of pain and by controlling unsteadiness subjecting the articular damage soreness were decreased greatly. So,early assessment of the pain will be more beneficial to the patient.
subject: Articles
  topic: section
subject: Subjective
  topic: keywords
subject: pain
  topic: keywords
subject: scientific evidence
  topic: keywords
subject: Rational
  topic: keywords
subject: pain assessment
  topic: keywords
creator: Shaik Mabu Subhani
creator: Paruchuri Mounika
creator: Gangisetty Sampath
creator: Chevula Nikhila
creator: Manchala Vamsi Vardhan
creator: V. Satyanarayana
creator: M. Prasada Rao
rights: Copyright (c) 0
date: 2025-01-20
publication date: 2025-01-20
starting page: 54
ending page: 56
doi: 10.61096/ijrpp.v14.iss1.2025.54-56

In Vivo Anti Diabetic Activity Of Helicteres Isora On Streptozotocin-Induced Diabetic In Rats
type: item
description: Helicteres Isora root is a well-known antidiabetic medicinal plant used for several traditional medicine aspects in different areas of the world, including India. This study includes phytochemical analysis, antidiabetic evaluation. The root of Helicteres Isora has been used in traditional health systems to treat diabetes mellitus in India. However, the antidiabetic activity of this medicinal plant is not scientifically validated and authenticated. The present study aimed to investigate the in vitro and in vivo anti-diabetic activity of root crude extract and solvent fractions of Helicteres Isora. The aim of this study was to investigate the antidiabetic activity and mechanism of action of Ethanolic extract prepared from Helicteres Isora root. Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of Streptozotocin -induced diabetic Rats. The result demonstrated the beneficial biochemical effects of Helicteres Isora root extract by inhibiting α–amylase improving serum lipid profile levels. The root crude extract are effective in lowering blood glucose levels in diabetic and hypoglycemic rats. The claimed traditional use as antidiabetic has scientific ground.
subject: Articles
  topic: section
subject: Diabetes mellitus
  topic: keywords
subject: Herbal medicine
  topic: keywords
subject: Helicteres Isora root
  topic: keywords
subject: Streptozotocin
  topic: keywords
subject: Anti diabetic activity
  topic: keywords
creator: Prathikantam Madhushalini
creator: D. Swathi
creator: K. Chaitanyaprasad
creator: K. Shravankumar
rights: Copyright (c) 0
date: 2025-01-24
publication date: 2025-01-24
starting page: 57
ending page: 66
doi: 10.61096/ijrpp.v14.iss1.2025.57-66

Comprehensive Review of Diabetes Mellitus: Current Perspectives, Challenges, and Emerging Frontiers
type: item
description: Diabetes Mellitus (DM) remains a prominent global health concern, involving intricate disruptions in insulin secretion, insulin action, or both. Over the past century, evolving research and clinical insights have reshaped understanding of this disease from its historical recognition in ancient medical texts to contemporary approaches informed by genomics and precision medicine. In Type 1 Diabetes Mellitus (T1DM), autoimmune processes target pancreatic beta cells, resulting in absolute insulin deficiency, whereas Type 2 Diabetes Mellitus (T2DM) arises from insulin resistance and a progressive loss of beta-cell function. Advances in diagnostic methodologies, including continuous glucose monitoring, enhance the identification of glycemic variability, while comprehensive management strategies emphasize the synergy of pharmacologic agents, such as metformin and incretin-based therapies, with structured lifestyle interventions. However, persistent challenges remain: chronic hyperglycemia predisposes individuals to a host of microvascular and macrovascular complications, posing a substantial clinical and economic burden. Emerging therapeutic frontiers ranging from islet cell transplantation to CRISPR-mediated gene editing hold promise for transformative outcomes. Nonetheless, socioeconomic and cultural barriers continue to drive global disparities in access to optimal care. Future efforts must integrate innovative technologies, personalized treatment paradigms, and public health initiatives to address this pervasive metabolic disorder. By synthesizing cutting-edge scientific discoveries with patient-centered care, clinicians and researchers can work collaboratively to mitigate the escalating impact of diabetes on both individual lives and healthcare systems worldwide.
subject: Articles
  topic: section
subject: Diabetes Mellitus
  topic: keywords
subject: Insulin Resistance
  topic: keywords
subject: Continuous Glucose Monitoring
  topic: keywords
subject: Precision Medicine
  topic: keywords
subject: Chronic Complications
  topic: keywords
creator: A Jayasree
creator: Mahendar Uduthala
creator: Narsanna Jeeru
creator: Jeevan Kumar Manikonda
creator: Nishant Tiwari
rights: Copyright (c) 0
date: 2025-01-29
publication date: 2025-01-29
starting page: 67
ending page: 76
doi: 10.61096/ijrpp.v14.iss1.2025.67-76

Study on Assessment of Drug Compliance in Diabetic Patients in Rural Area of Dharmapuri District Tamilnadu
type: item
description: Aim: The study aimed to assess drug compliance among diabetic patients residing in the rural areas of Dharmapuri district, Tamil Nadu, and to evaluate related factors affecting their quality of life. Methods: A cross-sectional study was conducted from August 2024 to January 2025, involving 100 diabetic patients diagnosed with Type II Diabetes Mellitus. Participants were chosen through quota sampling from two rural areas, with data collected via a structured questionnaire focusing on drug compliance and quality of life across four domains: social health, physical health, physiological health, and environmental health. Results: Gender distribution analysis showed a slightly higher prevalence of diabetes in females (51%) compared to males (49%). Compliance issues were often linked to factors such as knowledge deficits and accessibility to healthcare facilities. Conclusion: Improving patient education and establishing more accessible healthcare services are essential to enhance drug compliance and overall quality of life for diabetic patients in rural areas. These findings underscore the need for targeted interventions to address the unique challenges faced by this population.
subject: Articles
  topic: section
subject: Diabetes mellitus
  topic: keywords
subject: drug compliance
  topic: keywords
subject: rural health
  topic: keywords
subject: quality of life
  topic: keywords
creator: Pinky Kesmeera M
creator: Chandra S
creator: Billgates V
creator: Pradeep G
creator: Lokesh S
creator: Prasanth M
rights: Copyright (c) 0
date: 2025-02-05
publication date: 2025-02-05
starting page: 77
ending page: 83
doi: 10.61096/ijrpp.v14.iss1.2025.77-83

The Role Of Immunostimulants In Improving The Immunity In Autoimmune Diseases
type: item
description: The proper functioning of human immune system is essential for organism survival against infectious, toxic and oncogenic agents. Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants. Immunostimulants can enhance body’s resistance against various infections through increasing the basal levels of immune response. These agents could increase the oxidative activity of neutrophils, augment engulfment activity of phagocytic cells and stimulate cytotoxic cells as necessary defense mechanisms. The immunostimulants are classified on the basis of origin and mode of action such as bacterial products, complex carbohydrates, vaccines, cytokines, immunoenhancing drugs, nutritional factors, animal extracts, and plant extracts. The link between immune system with diet, exercise, sleep, stress, microbial exposure, alcohol, water,hygiene are found to influence the immune response to a greater extent. Immunostimulants and some immunity enhancing nutrients improve the functioning of the immune system.
subject: Articles
  topic: section
subject: Immunomodulators
  topic: keywords
subject: Immunostimulants
  topic: keywords
subject: Adjuvant
  topic: keywords
subject: Mechanism
  topic: keywords
subject: Immune system
  topic: keywords
creator: Manegar Akhleela
creator: Anupama Priyadarshini
creator: Maimoona Sadaf
creator: Syeda Ummehani
creator: Muskan
creator: Sufiya Sanober
creator: Saniya Nishath
creator: Faizan Akram
creator: G. Sudhakara Rao
creator: Shubam Nandu Thakare
rights: Copyright (c) 0
date: 2025-02-08
publication date: 2025-02-08
starting page: 84
ending page: 88
doi: 10.61096/ijrpp.v14.iss1.2025.84-88

A comprehensive analysis of the risk variables linked to HIV infection
type: item
description: The current review on factors that makes HIV more likely. Human immunodeficiency is caused by an immunodeficiency virus that targets the host’s T cells. An advanced stage of HIV infection causes AIDS. HIV is a major public health challenge. These review discuss the risk factors for HIV infection, such as frequent sexual partners, unprotected sex, and high-risk sexual behaviours such condom-less anal intercourse. , HIV can be passed from mother to infant during pregnancy and delivery and sharing contaminated needles, syringes, and other injecting equipment, or drug solutions when injecting drugs and connected to transfusion Errors in blood bank procedures, such as contamination during blood collection, processing, or storage, can potentially result in HIV infection. Inflammation of the genital mucosa and the presence of other STIs make women more susceptible to HIV infection through heterosexual vaginal relationships. Getting another STI, such as syphilis, herpes, chlamydia, gonorrhoea, or bacterial vaginosis. And receiving medical procedures that involve unsterile cutting or piercing; or unintentional needle stick injuries, including among healthcare professionals. Another risk factor for HIV infection is socioeconomic status of public.
subject: Articles
  topic: section
subject: immunodeficiency
  topic: keywords
subject: intercourse
  topic: keywords
subject: contamination
  topic: keywords
subject: equipment
  topic: keywords
subject: transfusion
  topic: keywords
subject: inflammation
  topic: keywords
subject: heterosexual
  topic: keywords
subject: vaginosis
  topic: keywords
subject: chlamydia
  topic: keywords
subject: gonorrhoea
  topic: keywords
subject: syphilis
  topic: keywords
creator: Shaik Parveen
creator: P. Pravalika
creator: B. Anusha
creator: B. Mahima
rights: Copyright (c) 0
date: 2025-02-11
publication date: 2025-02-11
starting page: 89
ending page: 94
doi: 10.61096/ijrpp.v14.iss1.2025.89-94

Pharmacist Intervention in early detection and prevention of Mi Risk Among Adults
type: item
description: Background: In the modern competitive world, cardiovascular challenges are becoming common and becoming responsible for early deaths. Myocardial Infarction (MI) is a predominant cause of pre-mature deaths. Numerous Procedures have been applied to evaluate MI risk. For the evaluation of MI risk, a separately developed MIRAT is employed. Even though significant strides have been achieved to reduce mortality, coronary artery disorders (CAD) remain the leading cause of death in many nations, making it one of the major health issues facing the world. Therefore, one of the most crucial health concerns in many nations, including Iran, may be the need to investigate risk and effective factors for CAD. Objective: To evaluate the threat of Myocardial infarction among people in the middle age population using the MIRAT Method: This is a prospective interventional study carried out over a length of 24 weeks after obtaining the institutional Human Committee approval. MIRAT was used in this research which includes 16 self-reporting questions covering age, gender, diabetic history, smoking history, records of hypertension, and family records of coronary heart assault prior 55 years of age etc., This information helps to evaluate the hazard of Myocardial infraction based on danger score criteria. In case the resulting points are greater than 10, considered patients are at greater threat of getting MI. Results: Using the inclusion criteria, 100 subjects were involved in the research. 36 of them were women, while 64 of them were men. The ages 35 to 50 made up the bulk of the population, while 23% of people were from an agricultural background and 38% were from the business sector. Twenty-two (22%) of the 100 participants were found to possess a greater threat of developing MI. Conclusion: The study's findings showed that the MIRAT can be used to foretell the possibility of time ahead of Myocardial infarction.
subject: Articles
  topic: section
subject: Cardiovascular
  topic: keywords
subject: coronary artery disease
  topic: keywords
subject: hypertension
  topic: keywords
subject: myocardial Infarction
  topic: keywords
subject: Myocardial Infarction Risk Assessment Tool
  topic: keywords
subject: self-reporting questionnaire
  topic: keywords
creator: Shaik Parveen
creator: A. Sri Charan
creator: K. Devasri
creator: S. Sri Vaishnavi
rights: Copyright (c) 0
date: 2025-02-11
publication date: 2025-02-11
starting page: 95
ending page: 101
doi: 10.61096/ijrpp.v14.iss1.2025.95-101

Unlocking the potential of stem cell therapy for Autism: A new era in neurotherapeutics
type: item
description: Autism spectrum disorders have distinct core symptoms, including struggles with social interactions and repetitive behaviours. These disorders involve complex neurodevelopmental problems, inflammation, and immune system dysfunction. Due to the underlying neurobiological causes of autism, researchers have explored the potential of cell-based therapies, such as stem cells, to treat the condition. Stem cells exhibit unique immunological properties, making them a promising area of study for autism treatment. This review examines autism's cellular and molecular abnormalities, potential stem cell therapies, animal models, and ongoing clinical trials. Research on autism's genetics shows that no proven cure exists, but studying stem cells has led to promising results, particularly with mesenchymal stem cells and human embryonic stem cells. These cells have been used to reduce autism severity and improve quality of life. Additionally, stem cells have been used to model various autism forms, such as Rett Syndrome and Fragile X Syndrome, allowing researchers to develop novel therapies. However, researchers must consider the ethical implications of their work, particularly when studying children, and prioritize their well-being and safety.
subject: Articles
  topic: section
subject: Autism Spectrum Disorder
  topic: keywords
subject: Stem Cells
  topic: keywords
subject: Cell Therapy
  topic: keywords
subject: Modelling
  topic: keywords
subject: Treatment
  topic: keywords
subject: Hypoperfusion
  topic: keywords
creator: Shaik Parveen
creator: Ravulapally Ashwitha
creator: Thadakokkula Keerthana
creator: Gutha Sisira Pushpa
creator: Rudroju Sri Vardhan Chary
rights: Copyright (c) 0
date: 2025-02-11
publication date: 2025-02-11
starting page: 102
ending page: 110
doi: 10.61096/ijrpp.v14.iss1.2025.102-110

Contemporary Strategies In The Pharmacological Management Of Hypertension
type: item
description: Hypertension remains a prevalent and significant risk factor for cardiovascular diseases globally, necessitating effective and evolving treatment strategies. Contemporary pharmacological management of hypertension has shifted toward personalized therapy, emphasizing the use of novel drug classes alongside traditional agents. Current antihypertensive strategies include the use of renin-angiotensin-aldosterone system (RAAS) inhibitors, calcium channel blockers, beta-blockers, and diuretics, often in combination, to optimize blood pressure control. Newer agents, such as direct renin inhibitors, angiotensin receptor blockers (ARBs) with enhanced efficacy, and selective aldosterone antagonists, have expanded treatment options, especially for patients with coexisting conditions like diabetes and chronic kidney disease. Additionally, the integration of fixed-dose combination therapies has improved adherence and patient outcomes. Personalized medicine, guided by genetic and phenotypic factors, further refines treatment regimens, ensuring better tolerability and effectiveness. As research continues, novel biomarkers and non-pharmacological interventions are also being explored to complement pharmacological therapies, ultimately aiming for a more holistic and effective approach to hypertension management.
subject: Articles
  topic: section
subject: Renin-angiotensin-aldosterone system
  topic: keywords
subject: Personalized medicine
  topic: keywords
subject: Fixed-dose combinations
  topic: keywords
subject: Cardiovascular risk
  topic: keywords
subject: Novel antihypertensive agents
  topic: keywords
creator: Shaik Parveen
creator: K. Pavithra
creator: K. Pranaya Rani
creator: B. Abhinav Raghavendra
rights: Copyright (c) 2024
date: 2025-02-11
publication date: 2025-02-11
starting page: 111
ending page: 118
doi: 10.61096/ijrpp.v14.iss1.2025.111-118

Role of gabaergic Drugs in the Treatment of Anxiety and Epilepsy
type: item
description: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Dysfunction of the GABAergic system has been implicated in various neurological and psychiatric disorders, particularly anxiety and epilepsy. GABAergic drugs, which modulate the GABA receptor activity, have become crucial therapeutic agents in managing these conditions. This review explores the mechanisms of action, clinical applications, and recent advancements in GABAergic drugs for the treatment of anxiety and epilepsy. Given the critical role of GABA in modulating neuronal excitability, the GABAergic system has been, and continues to be, an important target for efforts to identify new therapies for epilepsy, convulsive status epilepticus and other CNS disorders, including anxiety, sleep and depression.
subject: Articles
  topic: section
subject: GABAergic system
  topic: keywords
subject: seizures
  topic: keywords
subject: epilepsy
  topic: keywords
subject: anxiety etc
  topic: keywords
creator: Koyyalamudi shalem raju
creator: Raja Kumar.Biddika
creator: Haritha.kathi
creator: Ramanaiha.Ratham
creator: Prasad.yamme
rights: Copyright (c) 0
date: 2025-02-13
publication date: 2025-02-13
starting page: 119
ending page: 125
doi: 10.61096/ijrpp.v14.iss1.2025.119-125

Navigating The Pharmacological Landscape Of Asthma Management: Current And Future Trends
type: item
description: This paper reviews asthma treatment advancements, particularly short-acting β2 agonists (SABAs) and innovative therapies. While SABAs have been essential since the 1950s, low patient adherence often leads to overuse and poor outcomes. This review examines the pharmacology of inhaled SABAs and presents as-needed inhaled corticosteroids (ICS) with formoterol as a promising alternative for swift relief. With asthma remaining a critical global health issue, recent progress in pharmacotherapy—such as digital therapies, precision medicine, and new drug classes—offers new hope for better management. The analysis highlights the urgent need to tackle unmet requirements in cost, accessibility, and adherence, especially in resource-limited settings, to ensure optimal care for all patients.
subject: Articles
  topic: section
subject: Bronchodilators
  topic: keywords
subject: Anti cholinergic
  topic: keywords
subject: Mast cell stabilisers
  topic: keywords
subject: Methyl xanthines
  topic: keywords
subject: Leukotriene antagonist
  topic: keywords
subject: Digital technologies
  topic: keywords
subject: Biologic therapies
  topic: keywords
subject: Mechanism of action
  topic: keywords
subject: Pharmacological actions
  topic: keywords
subject: Pharmacokinetics
  topic: keywords
subject: Adverse effects
  topic: keywords
subject: Contraindications Uses
  topic: keywords
creator: Shaik Parveen
creator: M. Rishitha
creator: Ch. Niharika
creator: G. Rajini
rights: Copyright (c) 0
date: 2025-02-15
publication date: 2025-02-15
starting page: 126
ending page: 138
doi: 10.61096/ijrpp.v14.iss1.2025.126-138

Exploring the Adaptogenic Power of Withania somnifera: Mechanisms of Stress Alleviation and Implications for Mental Health and Wellness
type: item
description: Stress, a hallmark of contemporary lifestyles, exerts a profound influence on both physical and mental health. Increasingly, adaptogenic herbs are recognized for their capacity to bolster the body’s resilience against stress-related challenges. Withania somnifera (Ashwagandha), a cornerstone of Ayurvedic medicine, has garnered significant scientific interest due to its ability to modulate the stress response and enhance holistic well-being. This review offers a comprehensive examination of W. somnifera’s adaptogenic properties, with an emphasis on mechanisms of stress alleviation, mental health benefits, and broader applications. Key bioactive compounds, such as withanolides, underlie the herb’s anti-stress, anxiolytic, and neuroprotective actions, mediated in part through regulation of the hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter pathways, and inflammatory processes. Clinical evidence underscores its efficacy in reducing cortisol levels, mitigating anxiety and depression, and improving cognitive function. Furthermore, W. somnifera exhibits immunomodulatory and antioxidant effects, supporting physical performance and recovery. Despite robust findings, challenges persist in standardizing formulations and elucidating molecular mechanisms. This review synthesizes current data on W. somnifera’s therapeutic value and safety, highlighting its potential as an integrative intervention in mental health and stress management. Future research focusing on long-term efficacy, optimal dosages, and formulation consistency will likely expand its clinical relevance. Overall, Ashwagandha stands as a promising, evidence-based adaptogen poised to bridge traditional therapeutic wisdom with modern scientific validation.
subject: Articles
  topic: section
subject: Withania somnifera
  topic: keywords
creator: G. Mamatha
creator: N. Aravind
creator: P. B. Radha Krishna
creator: P. Hamsika
creator: P. Saipreethi
creator: P. Niharika
rights: Copyright (c) 0
date: 2025-02-25
publication date: 2025-02-25
starting page: 139
ending page: 145
doi: 10.61096/ijrpp.v14.iss1.2025.139-145

A Review of Cardioprotective Properties of Various Medicinal Plants
type: item
description: This review examines the cardioprotective properties of various traditional medicinal plants, highlighting their potential in treating and preventing cardiovascular diseases. The cardiovascular system’s complexity and the growing burden of heart diseases have led to increased interest in natural therapeutic alternatives. We analyze twelve significant medicinal plants: Shatavari (Asparagus racemosus), Amla (Phyllanthus emblica), Grapes (Vitis vinifera), Arjun Tree (Terminalia arjuna), Tulsi (Ocimum sanctum), Katuka (Picrorhiza kurroa), Indian Laburnum (Cassia fistula), Kokum (Garcinia indica), Fenugreek (Trigonella foenum-graecum), Fox Glove (Digitalis purpurea), Garlic (Allium sativum), and Turmeric (Curcuma longa). Each plant is evaluated for its phytochemical composition, traditional uses, and experimental evidence supporting cardioprotective effects. The review particularly focuses on their roles in preventing and treating various cardiac conditions, including myocardial infarction, hypertension, and other cardiovascular disorders. The experimental studies cited demonstrate these plants’ efficacy through various mechanisms, including antioxidant, anti-inflammatory, and direct cardioprotective actions. This comprehensive analysis provides a foundation for future research in developing natural cardioprotective therapeutics while acknowledging the traditional wisdom of various medical systems.
subject: Articles
  topic: section
subject: Cardioprotective plants
  topic: keywords
subject: Traditional medicine
  topic: keywords
subject: Phytochemicals
  topic: keywords
subject: Cardiovascular diseases
  topic: keywords
subject: Natural therapeutics
  topic: keywords
creator: Farhana Farhi
creator: Dhineshmani Mani
creator: Mohamed Yasar Abdul
creator: Azhagu Natchiyan
creator: Barathi Lingam
creator: Kamila Banu
creator: Maariya Nisa
rights: Copyright (c) 0
date: 2025-02-25
publication date: 2025-02-25
starting page: 146
ending page: 154
doi: 10.61096/ijrpp.v14.iss1.2025.146-154

A Case Report On Montelukast And Fexofenadine Induced Depression And Nightmares
type: item
description: Depression and nightmares are caused by Montelukast. Montelukast is a selective leukotriene receptor antagonist (LRTA) and US-FDA issued a black box warning in 2020. In this case report, a 14 year old female was prescribed a combination of Tab. Montelukast and Tab. Fexofenadine for the treatment of bronchial asthma exacerbations. After this, she started experiencing multiple episodes of depression and nightmares. The patient was asked to avoid Montelukast after which the patient's condition improved and she was started on MDI Formoterol fumarate and Budesonide powder for inhalation and Tab. Desloratadine for further management. After stopping the drug, her condition improved. This case underlines the importance of monitoring for rare but serious side effects of leukotriene receptor antagonist and highlights the need for further research into their mechanisms and risk factors.
subject: Articles
  topic: section
subject: Montelukast
  topic: keywords
subject: depression
  topic: keywords
subject: nightmare
  topic: keywords
subject: bronchial asthma
  topic: keywords
subject: Fexofenadine
  topic: keywords
creator: Christeena Mary Viji
creator: Karun Kumar
rights: Copyright (c) 0
date: 2025-03-04
publication date: 2025-03-04
starting page: 155
ending page: 157
doi: 10.61096/ijrpp.v14.iss1.2025.155-157

A Case Report On Donepezil Induced Cervical Dystonia
type: item
description: Cervical dystonia, is a neurological condition characterized by involuntary neck muscle contractions, abnormal head and neck postures. This case report describes a 63-year-old male with Parkinsonism and early dementia who developed severe cervical dystonia after starting Donepezil, a cholinesterase inhibitor used to manage cognitive impairment. The patient came with complaints of difficulty in sitting, mild rigidity and anterior neck flexion. Discontinuation of Donepezil led to significant improvement; subsequent treatment with Trihexyphenidyl was effective. This case underscores the importance of monitoring for rare but serious side effects of cholinesterase inhibitors and highlights the need for further research into their mechanisms and risk factors.
subject: Articles
  topic: section
subject: Donepezil
  topic: keywords
subject: Cervical dystonia
  topic: keywords
subject: Parkinsonism
  topic: keywords
subject: Trihexyphenidyl
  topic: keywords
creator: Ranimol Mathew
creator: Karun Kumar
creator: Jacob Jesurun R
creator: Rinku Elsa Reji
rights: Copyright (c) 0
date: 2025-03-04
publication date: 2025-03-04
starting page: 158
ending page: 160
doi: 10.61096/ijrpp.v14.iss1.2025.158-160

Escitalopram-Induced Hyponatremia and Neurological Adverse Effects: A Case Series
type: item
description: Escitalopram is a Selective Serotonin Receptor Inhibitor (SSRI) prescribed for the management of anxiety, major depressive disorders, agitation, and dementia. Hyponatremia is a familiar side effect of SSRIs; however, there are only a few pieces of literature that give evidence of escitalopram-induced hyponatremia and hyponatremic encephalopathy. SSRIs are also known to cause rare neurological side effects, such as extrapyramidal symptoms like tremulousness, Parkinsonism, which often go unlisted. SSRIs also shows an example of drug-induced psychiatric disorders such as visual hallucinations.
subject: Articles
  topic: section
subject: Selective Serotonin Receptor Inhibitors
  topic: keywords
subject: hyponatremia
  topic: keywords
subject: hyponatremic encephalopathy
  topic: keywords
subject: Parkinsonism
  topic: keywords
subject: Escitalopram
  topic: keywords
creator: Christeena Mary Viji
creator: Karun Kumar
creator: Merin.V. Jolly
creator: Harikrishnan S
creator: Jacob Jesurun R
rights: Copyright (c) 0
date: 2025-03-04
publication date: 2025-03-04
starting page: 161
ending page: 166
doi: 10.61096/ijrpp.v14.iss1.2025.161-166

Phytoniosomal gel of acalypha indica: a novel topical delivery system for anti-inflammatory activity
type: item
description: This study aimed to develop and evaluate an anti-inflammatory gel formulation utilizing Acalypha indica phytoniosomes. Acalypha indica, a traditional medicinal plant, possesses potent anti-inflammatory properties attributed to various bioactive compounds. Phytoniosomes are novel drug delivery systems that combine the therapeutic benefits of plant extracts (phytoconstituents) with the advantages of niosomes. They form stable complexes that enhance the bioavailability, stability, and targeting of the phytoconstituents. The study involved formulating a gel base incorporating Acalypha indica phytoniosomes and evaluating its physicochemical properties (pH, viscosity, spreadability) and in vitro release characteristics. The developed gel demonstrated promising anti-inflammatory potential, with sustained release of Acalypha indica phytoconstituents. This research provides a foundation for further investigation into the clinical application of this novel gel formulation for the management of inflammatory skin conditions.
subject: Articles
  topic: section
subject: niosomes
  topic: keywords
subject: phytoconstituents
  topic: keywords
subject: phytoniosomes
  topic: keywords
subject: delivery systems
  topic: keywords
subject: sustained release
  topic: keywords
subject: formulation
  topic: keywords
creator: K. Neelima Devi
creator: M.L.N.T. Amaleswari
creator: Vikas Kandapu
creator: Karnam Keerthana
creator: Kammari Sai Charan
creator: Kata Sanjay
creator: Kathi Mahathi
rights: Copyright (c) 0
date: 2025-03-05
publication date: 2025-03-05
starting page: 167
ending page: 175
doi: 10.61096/ijrpp.v14.iss1.2025.167-175

Formulation and evaluation of herbal tablet from moringa Oleifera leaves
type: item
description: The aim of the study is formulation and evaluation of herbal tablets from moringa oleifera leaves. Moringa oleifera leaves was extracted with ethanol and formulated by using different binders which included Gelatin, Micro-crystalline Cellulose (MCC), Maize Starch produced the best tablets of ethanol extract of Moringa oleifera leaves. Numerous criteria, including strength (friability, crushing strength), and release characteristics (disintegration and dissolution durations tests), were used to characterize the formulations. The outcome demonstrated that, in comparison to tablets made with MCC or maize starch, those made with gelatin as a binder had the lowest friability and disintegration time.
subject: Articles
  topic: section
subject: Moringa oleifera
  topic: keywords
subject: tablet
  topic: keywords
subject: Binder: gelatin
  topic: keywords
subject: MCC
  topic: keywords
subject: maize starch
  topic: keywords
creator: Chelle laxmi Prasanna
creator: Cheganti Rahul
creator: Chiluka Purvi
creator: Dara Harika
creator: Chethireddy Rajasimha
creator: Pratap devi shankar sai Prakash
creator: Meesala Gowthami
rights: Copyright (c) 0
date: 2025-03-05
publication date: 2025-03-05
starting page: 176
ending page: 182
doi: 10.61096/ijrpp.v14.iss1.2025.176-182

A retrospective study on prescription patterns and therapeutic approaches for various cancer chemotherapies in tertiary care hospital, Narasaraopet
type: item
description: Background: Cancer is a life-threatening disease that causes death. Cancer is the leading cause of death. There are several factors for the formation of cancers. According to survey conducted by the International Agency for Research on Cancer (IARC) and the American Cancer Society (ACS) in 2022 20 million new cancer cases are raised by 2022 and 9.7 million deaths. Aim/Objectives: This study assesses the prescription patterns and therapeutic approaches for various types of cancer. To evaluate the drug prescription patterns of Anti-Cancer drugs in cancer patients in tertiary care hospital, to observe different dose regimens, to study the efficacy of anti-cancer drugs in various cancer chemotherapies, and to determine the survival rate in cancer patients. Materials &methods: A retrospective observational study in a period of 5 months in a tertiary care hospital. Results: A total of 80 patients are enrolled in this study after diagnosed as the cancer. And majority of cancer patients are females. And cancer attacks majorly in the age group of 51-60. Cervix, and breast cancers in females are more. Based on the condition and severity of the patients the different types of cytotoxic drugs are used. Majorly the platinum-based drugs like cisplatin, carboplatin, and oxaliplatin are used. The drugs like ondansetron, dexamethasone, chlorpheniramine maleate, ranitidine, pantoprazole, and etc,. drugs are given to control or to suppress, the side effects caused by the cytotoxic drugs. Conclusion: The cytotoxic drugs are given in a controlled manner, there is a gap of 3 weeks for every chemotherapy cycle. The quality of life and survival rate can be increased by chemotherapy but there is a chance of death.
subject: Articles
  topic: section
subject: Chemotherapy
  topic: keywords
subject: carcinogens
  topic: keywords
subject: cancer
  topic: keywords
subject: tumor
  topic: keywords
subject: prescription patterns
  topic: keywords
subject: metastasis
  topic: keywords
subject: neoplasm
  topic: keywords
subject: cytotoxic drugs
  topic: keywords
creator: G. Lakshmana
creator: Nori Kodanda Ram
creator: P. Akshay
creator: SK. Shameera
creator: K. Triveni
creator: T. Gopinadh
creator: J. Tharun naik
creator: J. N. Suresh Kumar
rights: Copyright (c) 0
date: 2025-03-12
publication date: 2025-03-12
starting page: 183
ending page: 192
doi: 10.61096/ijrpp.v14.iss1.2025.183-192

Different Roles of Pharmacists As A Health Care Professionals
type: item
description: In terms of giving proficient administrations, the pharmacy profession has extended altogether and is presently recognized as fundamental to the multidisciplinary conveyance of wellbeing care. Since drug specialists are vital healthcare experts who progress persistent care and energize wellness, their position in society's healthcare is vital. Drug specialists are sometimes referred to as chemists and druggists in the therapeutic field. Drug specialists work with solutions and donate exact data approximately them. They moreover assist in the generation, detailing, quality control, standardization, compounding and apportioning of different dose shapes so that they can be utilized to treat a variety of maladies. In the healthcare framework, the drug specialist works in various ways, such as Investigate and Improvement (R&D) segment, creating new drug definitions, and keeping up legitimate security and poisonous quality of the drugs. The drug specialist is vital for the slight elderly populace in essential care. The part of drug specialists has been growing around the Globe, in the present time, as an case the COVID-19 widespread. In pith, drug specialists are essential to the wellbeing care framework. The article makes a difference distinguish pharmacists' various parts in diverse healthcare framework areas to create a healthier world., which is all emphasize themes of protection, royal authority, and well-being. It is also believed to be an abbreviation for the Latin word "recipe," meaning "Take" (referring to the medicine). Additionally, the symbol is associated with the zodiac sign of Jupiter.
subject: Articles
  topic: section
subject: Pharmacist, Central Drug dispensing Area, Clinical pharmacy, Patient Counselling, Drug safety, Health Education, Medication Adherence
  topic: keywords
creator: Shaik Parveen
creator: G. Varshini
creator: J. Keerthana
creator: N. Abhinaya
rights: Copyright (c) 0
date: 2025-03-14
publication date: 2025-03-14
starting page: 193
ending page: 202
doi: 10.61096/ijrpp.v14.iss1.2025.193-202

A brief overview of Chandipura virus
type: item
description: Chandipura Virus (CHPV), part of the Rhabdoviridae family, causes outbreaks primarily in rural India, affecting children with influenza-like symptoms and neurological issues. Transmitted by vectors like mosquitoes, ticks, and sand flies, CHPV has a negative-sense RNA genome encoding five proteins (N, P, M, G, L). The P protein is crucial for the viral life cycle, while the M protein is highly lethal. Currently, no specific treatment exists, but symptomatic management includes using mannitol to reduce brain edema. A Vero cell- based vaccine candidate has shown promise as a preventive measure. Effective control involves vector management, maintaining nutrition, hygiene, and increasing awareness in rural areas. Until an effective antiviral agent is developed, preventive measures such as public health education and vector containment remain critical in curbing CHPV outbreaks.
subject: Articles
  topic: section
subject: Chandipura Virus
  topic: keywords
subject: mannitol
  topic: keywords
subject: Rhabdoviridae family
  topic: keywords
creator: Dr. Kiran G
creator: M. Pravallika
creator: Sk. Sameena
creator: K. Pradeep
rights: Copyright (c) 0
date: 2025-03-21
publication date: 2025-03-21
starting page: 203
ending page: 206
doi: 10.61096/ijrpp.v14.iss1.2025.203-206

A review on dicarboxylic acids and their derivatives used to treat diabetes
type: item
description: Diabetes mellitus is a chronic and complex condition that disrupts how the body breaks down proteins, fats, and sugars. It is described as being incapable of decreasing the blood sugar levels. Type 1 diabetes is caused by β cell failure in the pancreas, whereas type 2 diabetes is caused by insufficient insulin and the body's resistance to it. Diabetes is considered a common disease. There are many drugs and techniques put into practice to control diabetes. The current drugs for diabetes, including insulin and other agents, have some problems. These include needing to be used for a long time, having bad side effects, and being expensive. Due to these problems, people are more likely to look for safer and cheaper medicines, such as plant-based medicines. The plants, which have natural ingredients, are now being studied in research.
subject: Articles
  topic: section
subject: Diabetes mellitus, Phytochemicals, Anti-diabetic drugs
  topic: keywords
creator: Kuchi Manjeera
creator: Korani Ramya
creator: V. V. Rajesham
creator: T. Rama Rao
rights: Copyright (c) 0
date: 2025-03-25
publication date: 2025-03-25
starting page: 207
ending page: 215
doi: 10.61096/ijrpp.v14.iss1.2025.207-215

A Comprehensive Overview On Pharmacovigilance Ensuring Drug Safety
type: item
description: In order to guarantee medication safety, enhance clinical procedures, and safeguard the public's health, pharmacovigilance is essential in identifying and controlling adverse drug reactions (ADRs). Expert systems are crucial for quickly detecting safety issues and averting product withdrawals because to the increasing amount of ADR data. Complex, cross-border safety issues can be better managed by implementing independent review methods and fortifying the worldwide pharmacovigilance network, such as through the Uppsala Monitoring Center. The creation of pharmacovigilance centers around the world has strengthened medication safety monitoring, despite ongoing issues including underreporting and data quality. Initiatives since the year 2000 have concentrated on enhancing drug safety systems, encouraging cooperation between researchers, healthcare providers, and regulatory bodies, and extensively sharing safety data. Pharmacovigilance developments have changed the strategy from changing from reactive to proactive, filling in the gaps, and enhancing medication safety. Along with lowering patient harm and promoting sensible prescription usage, these advancements have also increased confidence in healthcare systems around the world. Pharmacovigilance is becoming a vital instrument for public health protection.
subject: Articles
  topic: section
subject: Pharmacovigilance, Drug safety, Adverse Drug Reactions, Public health, Safety
  topic: keywords
creator: Asha Nandabaram
creator: Deepika Nadiminti
creator: Namitha Naluvala
creator: Manogna Nanded
creator: Rachana Nangunoori
creator: Panjala Saikiran Goud
rights: Copyright (c) 0
date: 2025-03-27
publication date: 2025-03-27
starting page: 216
ending page: 226
doi: 10.61096/ijrpp.v14.iss1.2025.216-226

Drug Safety in Pregnancy and Lactation: A Review of Current Guidelines
type: item
description: The use of medications during pregnancy and lactation poses unique challenges for healthcare providers. Drug safety must be carefully evaluated to prevent adverse effects on the developing fetus or the breastfeeding infant. This review discusses the current guidelines for the use of medications during pregnancy and lactation, focusing on risk classification systems, commonly used medications, and strategies to minimize risks while ensuring effective treatment.
subject: Articles
  topic: section
subject: Pregnancy and medication safety, Lactation and drug use, FDA Pregnancy and Lactation Labeling Rule (PLLR), Teratogenicity, Breastfeeding and pharmacology
  topic: keywords
creator: Divya Jonnalagadda
creator: D. Kanchana
creator: B. Likitha
creator: G. Anusha
creator: B. Lokeshwaro
rights: Copyright (c) 0
date: 2025-03-27
publication date: 2025-03-27
starting page: 227
ending page: 231
doi: 10.61096/ijrpp.v14.iss1.2025.227-231

The Usage Of Biomarkers In The Early Detection Of Diseases
type: item
description: This review discusses the definition and types of biomarkers. It also reviews the potential use of biomarkers in diagnosing, Treating, Predecting the course of various diseases such as cardiovascular, Infectious, Cancer. The current review focuses on biomarkers for CVD, Infectious, Cancer and the procedures that should be consider to establish the comprehensive nature of the expression of biomarkers for cardiovascular diseases. It also discusses how biomarkers can help with treatment decisions and monitoring disease progression.
subject: Articles
  topic: section
subject: Biomarker, Diagnosis, Therapeutics, Biomolecular system, CVD, Cancer, Infectious disease.
  topic: keywords
creator: Kodela. Sesi
creator: Chegu. Kartheek
creator: Pratti. Naga Sravani
creator: Hamsavath. Hanumanth Naik
creator: Hamsavath. Siva Kumar Naik
creator: M. Prasada Rao
rights: Copyright (c) 0
date: 2025-04-02
publication date: 2025-04-02
starting page: 232
ending page: 235
doi: 10.61096/ijrpp.v14.iss1.2025.232-235