@article{Seema Manak_Deep Inder_2022, title={Revisiting anti-inflammatory potential of colchicine and repurposing use of colchicine in Covid-19: A comprehensive review}, volume={11}, url={https://ijrpp.com/ijrpp/article/view/430}, DOI={10.61096/ijrpp.v11.iss2.2022.97-102}, abstractNote={<p>Colchicine is a known anti-inflammatory and antiproliferative drug obtained from plant known as Colchicum autumnale.&nbsp; In the past it has been used as an antiinflammatory drug in the gout and mediterranean fever and in several off label conditions. Despite concerns about its gastro-intestinal tolerability, drug interactions and narrow therapeutic window, colchicine has shown promise in many cardiovascular diseases including chronic pericarditis and ischaemic heart disease. &nbsp;Present review has been done with an objective to explore therapeutic and pleotropic anti-inflammatory effects of colchicine in various inflammatory clinical conditions including Covid-19 (SARS-CoV-2).&nbsp; Literature search has been carried out by all researchers using databases PubMed/MEDLINE, Google Scholar, EMBASE, SCOPUS and Cochrane (central) review. In the era of Covid-19, researchers across the globe are repurposing and exploring the role of colchicine in Covid-19 induced cytokine storm and inflammation.&nbsp; Using formulations of colchicine through targeted drug delivery approach may help in greater safety and acceptability of colchicine for various inflammatory conditions.</p&gt;}, number={2}, journal={International Journal of Research in Pharmacology & Pharmacotherapeutics}, author={Seema Manak and Deep Inder}, year={2022}, month={May}, pages={97-102} }