@article{Jayakumar Paramasivam_KenyiEte_Nang AratiNamchoomEte_Jaikumar Sankarapillai_2021, title={Influence of Toddalia asiatica on cardio biomarkers and its protective role against Isoproterenol Induced Myocardial Infarction in Rats}, volume={7}, url={https://ijrpp.com/ijrpp/article/view/237}, DOI={10.61096/ijrpp.v7.iss1.2018.80-84}, abstractNote={<p>The objective of the study was to evaluate the influence of ethanolic leaf extract of <em>Toddalia asiatica</em> on cardio biomarkers against isoproterenol induced myocardial infarction in rats. The protective activity of <em>Toddalia asiatica</em> was assessed by estimating the cardiac marker enzymes (Creatinine Phosphokinase and Lactate Dehydrogenase) and antioxidants enzymes (superoxide dismutase and Catalase). Thirty male Sprague – Dawley rats were randomly allocated in 5 groups of 6 each. Group I served as control, II to V animals were Isoproterenol (85mg/kg) induced&nbsp; myocardiaol infracted animals, pre treated with the reference control Lipistat (350mg/kg) and ethanolic leaf extract of<em> Toddalia asiatica</em> (200 &amp; 400 mg/kg). All the test drugs were administered orally for 15 days. On 16<sup>th</sup> day the blood was collected and subjected to the estimation of cardiac marker enzymes. The animals were sacrificed; hearts were homogenized and used for the estimation of antioxidant enzymes. The result showed that, <em>Toddalia asiatica</em> significantly decreased the cardiac marker enzyme and increased the antioxidant enzymes. <em>Toddalia asiatica</em> produced a dose dependent cardioprotective effect against the acute cardiac damage induced by Isoproterenol in rats. From the result it was concluded that, <em>Toddalia asiatica</em> produced cardioprotective activity against isoproterenol induced cardiac damage in rats which was mediated by its antioxidant property.</p&gt;}, number={1}, journal={International Journal of Research in Pharmacology & Pharmacotherapeutics}, author={Jayakumar Paramasivam and KenyiEte and Nang AratiNamchoomEte and Jaikumar Sankarapillai}, year={2021}, month={Apr.}, pages={80-84} }