Main Article Content


The work was designed to evaluate the anti-diarrheal effects of aqueous extract of areca nut in combination with lime against castor oil induced diarrhea model and also to evaluate the anti-bacterial effect by disc diffusion method


Areca catechu lime Anti diarrheal effect Anti bacterial effect

Article Details

How to Cite
Rynu Tom Thykkaden, & ManoodeepChakraborthi. (2021). Antidiarrhoeal and antibacterial effects of areca nut and lime combination in experimental animals. International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(3), 396-399.


  1. [1]. WHO. Diarrhoeal Diseases Control Programme: interim programme report 1988 (WHO/CDD/89.31).
  2. [2]. Saralaya MG, Patel P, Patel M, Roy SP, Patel AN. Anti-diarrheal activity of methanolic extract of Moringaoleifera Lam roots I experimental animal models. Int J Pharm Res. 2(2), 2010, 35-39.
  3. [3]. Toyin YM, Khadijat OF, Saoban SS, Olakunle AT, Abraham BF, Luqman QA. Antidiarrheal activity of aqueous leaf extract of Ceratothecasesamoides in rats. Bangladesh J Pharmacol 7, 2012, 14–20.
  4. [4]. Krause R, Schwab E, Bachhiesl D, Daxböck F, Wenisch C, Krejs GJ, Reisinger EC. Role of Candida in antibiotic-associated diarrhea.J Infect Dis. 184(8), 2001, 1065-9.
  5. [5]. Maresca M, Mahfoud R, Garmy N, Kotler DP, Fantini J, Clayton F. The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line. J Biomed Sci. 10(1), 2003, 156-66.
  6. [6]. Sarin RV and Bafna PA. Herbal Antidiarrhoeals:A Review. Int J Res Pharm Biomed Sci 3(2), 2012 , 637.
  7. [7]. Capasso F, Mascolo N, Izzo AA, Gaginella TS. Dissociation of castor oil-induced diarrhoea and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester. Br J Pharmacol. 113(4), 1994, 1127-30.
  8. [8]. BC, Pai V and Varghese I, Shantaram M, Jose M. Antimicrobial properties of Areca catechu (8.Maria areca nut) husk extract against common oral pathogens. Int J Res Appl Pharm 3(1), 2012, 81.
  9. [9]. Maamori J. Evaluation of the anti-motilitty-related diarrhoeal activity of the sage tea Salvia officinalis L. in laboratory mice. Int J Biol 3(4), 2011, 36.
  10. [10]. Prasad SK, Laloo D, Kumar R,SahuAN, Hemalatha S. Anti-diarrheal evaluation of rizhomes of Crypyocorynespiralisfisch. Ex wydler: antimotility and antisecretory
  11. [11]. Galvez J, Zavzuelo A, Crespo ME, Lorente MD, Ocete MA, Jimenez J. Anti-diarrheic activity of Euphorbia hirta extract and isolation of an active flavanoid constituent. PlantaMedica. 59, 1993, 333-36.
  12. [12]. Konaté, K., Yomalan, K., Sytar, O., Brestic, M., 2015. Anti-diarrheal and anti-microbial Profiles extracts of the leaves from TrichiliaemeticaVahl. (Meliaceae). Asian Pac.J. Trop. Biomed. 5, 242–248.
  13. [13]. Gomes, A.T.; Smânia, Jr. A.; Seidel, C.; Smânia, E.F.A.; Honda, N.K.;Roese, F.M.; Muzzi, R.M. Anti-bacterial activity of orsellinates. Braz. J. Microbiol., 34, 2003, 194-196.